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    Method of producing solid shape forms containing an active ingredient
    3.
    发明授权
    Method of producing solid shape forms containing an active ingredient 有权
    制备含有活性成分的固体形状的方法

    公开(公告)号：US07014810B2

    公开(公告)日：2006-03-21

    申请号：US10149762

    申请日：2000-12-15

    申请人： Harald Krull ,  Jörg Rosenberg ,  Jörg Breitenbach ,  Jürgen Hofmann ,  Rainer Klenz ,  Hans Bührle

    发明人： Harald Krull ,  Jörg Rosenberg ,  Jörg Breitenbach ,  Jürgen Hofmann ,  Rainer Klenz ,  Hans Bührle

    IPC分类号： B29C45/03 ,  B29C45/72

    CPC分类号： B29C45/54 ,  A61J3/06 ,  A61K9/2095 ,  B29C45/542 ,  B29C2045/466 ,  B29C2045/545 ,  B29K2105/0035

    摘要： The present invention relates to an apparatus for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one polymeric binder. The apparatus according to the invention has at least one extruder 1 for continuous plastication of the formulation and at least two injection units 2 which are provided separate from one another, each of which is connected to the extruder 1, and through which the formulation can be injected into at least one mold 3. In the process according to the invention for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one binder, the active ingredient-containing formulation is continuously plasticated, the plasticated formulation is fed into an injection unit 21, and the formulation present in this injection unit 21 is injected into a mold 3, and plasticated formulation is fed into another injection molding unit 22, and the formulation present in the other injection molding unit 22 is injected into the mold 3 or another mold.

    摘要翻译： 本发明涉及包含至少一种聚合物粘合剂的含活性成分的制剂的含固体活性成分的形式的装置。 根据本发明的装置具有至少一个用于制剂的连续塑化的挤出机1和至少两个彼此分离的注射单元2，每个注射单元2彼此连接到挤出机1，并且制剂可以通过该挤出机1 注入至少一个模具3。 在根据本发明的用于由含有至少一种粘合剂的含活性成分的制剂生产含固体活性成分的制剂的方法中，含有活性成分的制剂被连续塑化，所述塑化的制剂进料到注射单元2' SUB＆gt; 1，并且将存在于该注射单元2 1中的制剂注射到模具3中，并且将塑化的制剂进料到另一个注射成型单元2 2 / >，并且存在于另一个注射成型单元2 2中的配方被注入到模具3或另一个模具中。

    Process for producing solid dosage forms
    4.
    发明授权
    Process for producing solid dosage forms 有权
    生产固体剂型的方法

    公开(公告)号：US06423256B1

    公开(公告)日：2002-07-23

    申请号：US09417070

    申请日：1999-10-13

    申请人： Stephan Kothrade ,  Jörg Breitenbach ,  Harald Krull ,  Thomas Kessler ,  Armin Lange ,  Werner Maier ,  Ulrich Reinhold

    发明人： Stephan Kothrade ,  Jörg Breitenbach ,  Harald Krull ,  Thomas Kessler ,  Armin Lange ,  Werner Maier ,  Ulrich Reinhold

    IPC分类号： A61K920

    CPC分类号： A61K31/192 ,  A61K9/2027 ,  A61K9/2095

    摘要： A process for producing solid dosage forms, in which (i) a plastic mixture of at least one pharmacologically acceptable polymeric binder with a K value of more than 75, at least one pharmaceutical active ingredient and, where appropriate, conventional pharmaceutical additives is prepared and (ii) the plastic mixture is shaped to the required dosage form, with step (i) being carried out under conditions of temperature and shear energy input such that the reduction in molecular weight of the polymeric binder, expressed as the difference in the K value, is less than 15 is described.

    摘要翻译： 一种制备固体剂型的方法，其中（i）至少一种药理学上可接受的聚合物粘合剂与K值大于75的塑料混合物，至少一种药物活性成分以及适当的常规药物添加剂，以及 （ii）将塑料混合物成形为所需剂型，步骤（i）在温度和剪切能量输入条件下进行，使得聚合物粘合剂的分子量的降低表示为K值的差异 ，小于15被描述。