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公开(公告)号:US20070037791A1
公开(公告)日:2007-02-15
申请号:US11503405
申请日:2006-08-14
申请人: Thomas Rawson , Brian Safina , Jennafer Dotson , Aihe Zhou , Ignacio Aliagas-Martin , Jason Halladay , Jun Liang , Matthias Rueth , Bing-Yan Zhu
发明人: Thomas Rawson , Brian Safina , Jennafer Dotson , Aihe Zhou , Ignacio Aliagas-Martin , Jason Halladay , Jun Liang , Matthias Rueth , Bing-Yan Zhu
IPC分类号: A61K31/55 , A61K31/538 , A61K31/498 , A61K31/43 , A61K31/424 , A61K31/4188 , C07D498/22
CPC分类号: C07D487/04 , C07D491/04
摘要: The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2, R3 and m are defined herein.
摘要翻译: 本发明提供了新的激酶抑制剂,其可用作例如治疗恶性肿瘤的治疗剂,其中化合物具有通式I,其中A,X,Y,Z,R a,R b,R c,R 1, R 2,R 3和m如本文所定义。
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公开(公告)号:US07749994B2
公开(公告)日:2010-07-06
申请号:US11503405
申请日:2006-08-14
申请人: Thomas E. Rawson , Brian Safina , Jennafer Dotson , Aihe Zhou , Ignacio Aliagas-Martin , Jason Halladay , Jun Liang , Matthias Rueth , Bing-Yan Zhu , Frederick Brookfield , Michael Prime , Birong Zhang , Jun M. Li
发明人: Thomas E. Rawson , Brian Safina , Jennafer Dotson , Aihe Zhou , Ignacio Aliagas-Martin , Jason Halladay , Jun Liang , Matthias Rueth , Bing-Yan Zhu , Frederick Brookfield , Michael Prime , Birong Zhang , Jun M. Li
IPC分类号: A61K31/55 , A61K31/538 , A61K31/424 , A61K31/4188 , C07D498/22
CPC分类号: C07D487/04 , C07D491/04
摘要: The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2, R3 and m are defined herein.
摘要翻译: 本发明提供新的激酶抑制剂,其可用作例如治疗恶性肿瘤的治疗剂,其中化合物具有通式I,其中A,X,Y,Z,R a,R b,R c,R 1,R 2,R 3和m定义 这里。
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公开(公告)号:US20090131407A1
公开(公告)日:2009-05-21
申请号:US12096586
申请日:2006-12-14
IPC分类号: A61K31/55 , C12N9/99 , A61K31/4188 , A61K31/4196 , C07D487/14 , C07D495/14 , A61P35/00
CPC分类号: C07D497/16
摘要: The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula (I): I wherein X, Y, Z, R1, R2, R3, Ra, Rb, and n are as described herein.
摘要翻译: 本发明提供新的激酶抑制剂,其可用作例如治疗恶性肿瘤的治疗剂,其中化合物具有通式(I):其中X,Y,Z,R 1,R 2,R 3,R a,R b和n为 如本文所述。
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公开(公告)号:US20050186198A1
公开(公告)日:2005-08-25
申请号:US11088511
申请日:2005-03-24
申请人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号: C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51 , A61K38/48 , A61K31/445 , A61K31/54 , A61K31/60
CPC分类号: C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
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公开(公告)号:US20070037813A1
公开(公告)日:2007-02-15
申请号:US11537482
申请日:2006-09-29
申请人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人: Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号: A61K31/50 , A61K31/44 , A61K31/165 , C07D237/02
CPC分类号: C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译: 具有如下结构的化合物可用于抑制丝氨酸蛋白酶,例如TF /因子VIIa,因子Xa,凝血酶和激肽释放酶。 这些化合物可用于预防和/或治疗凝血障碍的方法。
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公开(公告)号:US06919369B2
公开(公告)日:2005-07-19
申请号:US10224114
申请日:2002-08-19
申请人: Ignacio Aliagas-Martin , Dean R. Artis , Michael S. Dina , John A. Flygare , Richard A. Goldsmith , Regina A. Munroe , Alan G. Olivero , Richard Pastor , Thomas E. Rawson , Kirk D. Robarge , Daniel P. Sutherlin , Kenneth J. Weese , Aihe Zhou , Yan Zhu
发明人: Ignacio Aliagas-Martin , Dean R. Artis , Michael S. Dina , John A. Flygare , Richard A. Goldsmith , Regina A. Munroe , Alan G. Olivero , Richard Pastor , Thomas E. Rawson , Kirk D. Robarge , Daniel P. Sutherlin , Kenneth J. Weese , Aihe Zhou , Yan Zhu
IPC分类号: C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
CPC分类号: C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译: 具有如下结构的化合物可用于抑制丝氨酸蛋白酶,例如TF /因子VIIa,因子Xa,凝血酶和激肽释放酶。 这些化合物可用于预防和/或治疗凝血障碍的方法。
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公开(公告)号:US06472393B1
公开(公告)日:2002-10-29
申请号:US09509104
申请日:2000-03-21
申请人: Ignacio Aliagas-Martin , Dean R. Artis , Michael S. Dina , John A. Flygare , Richard A. Goldsmith , Regina A. Munroe , Alan G. Olivero , Richard Pastor , Thomas E. Rawson , Kirk D. Robarge , Daniel P. Sutherlin , Kenneth J. Weese , Aihe Zhou , Yan Zhu
发明人: Ignacio Aliagas-Martin , Dean R. Artis , Michael S. Dina , John A. Flygare , Richard A. Goldsmith , Regina A. Munroe , Alan G. Olivero , Richard Pastor , Thomas E. Rawson , Kirk D. Robarge , Daniel P. Sutherlin , Kenneth J. Weese , Aihe Zhou , Yan Zhu
IPC分类号: A61K3118
CPC分类号: C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要: Compounds having the structure shown below wherein A, B, N1, N2, X, Y, Q, R2, R5 and R6 are as defined herein are useful to inhibit serine protease enzymes, such as TF/factor VIIa factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译: 具有下述结构的化合物其中A,B,N1,N2,X,Y,Q,R2,R5和R6如本文所定义,可用于抑制丝氨酸蛋白酶,如TF /因子VIIa因子Xa,凝血酶和激肽释放酶 。 这些化合物可用于预防和/或治疗凝血障碍的方法。
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公开(公告)号:US08637537B2
公开(公告)日:2014-01-28
申请号:US13593776
申请日:2012-08-24
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D403/14 , A61K31/506 , A61K45/06
摘要: Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.
摘要翻译: 具有式I的化合物,其中A,Z,R 1a,R 1b,R 2,R 3,R 4,R 5,R 6,R 7,R 9,R 10,R a,R b和n如本文所定义是PAK1的抑制剂。 还公开了用于治疗癌症和过度增殖性疾病的组合物和方法。
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公开(公告)号:US20130225620A1
公开(公告)日:2013-08-29
申请号:US13593776
申请日:2012-08-24
IPC分类号: C07D403/14 , A61K45/06 , A61K31/506
CPC分类号: C07D403/14 , A61K31/506 , A61K45/06
摘要: Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.
摘要翻译: 具有式I的化合物,其中A,Z,R 1a,R 1b,R 2,R 3,R 4,R 5,R 6,R 7,R 9,R 10,R a,R b和n如本文所定义是PAK1的抑制剂。 还公开了用于治疗癌症和过度增殖性疾病的组合物和方法。
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