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公开(公告)号:US20070078106A1
公开(公告)日:2007-04-05
申请号:US11469515
申请日:2006-09-01
申请人: Thomas Spector , David Porter , Saad Rahim
发明人: Thomas Spector , David Porter , Saad Rahim
IPC分类号: A61K31/7072 , A61K31/513 , A61K9/48 , A61K9/20
CPC分类号: A61K31/70 , A61K9/0031 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/48 , A61K31/505 , A61K31/513 , A61K31/7072 , A61K45/06 , C07D239/54 , C07H19/06 , A61K2300/00
摘要: Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4 alkyl C2-6 alkenyl, 1-halo-C2-6 alkenyl and halo-substituted C2-6 alkynyl.
摘要翻译: 尿嘧啶还原酶灭活剂,特别是5-取代的尿嘧啶或5,6-二氢-5-取代的尿嘧啶,可加强5-氟尿嘧啶,尤其用于治疗癌症。 5-取代基选自溴,碘,氰基,卤素取代的C 1-4烷基C 2-6亚烯基,1-卤代-C 2 -6个链烯基和卤素取代的C 2-6炔基。