Biphenyl derivatives, production thereof and uses as medicines
    1.
    发明授权
    Biphenyl derivatives, production thereof and uses as medicines 有权
    联苯衍生物,其生产和用途作为药物

    公开(公告)号:US06617325B1

    公开(公告)日:2003-09-09

    申请号:US10031585

    申请日:2002-05-15

    IPC分类号: A01N4366

    CPC分类号: C07D211/58

    摘要: The present invention relates to biphenyl derivatives of general formula wherein Ra to Rg and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

    摘要翻译: 本发明涉及通用化学式R a至R g的联苯基衍生物,n如权利要求1中所定义,它们是微粒体甘油三酯转移蛋白(MTP)的有价值的抑制剂的异构体和盐,特别是其生理上可接受的盐,药物 含有这些化合物及其用途以及其制备方法。

    Substituted piperazine derivatives, the preparation thereof and their use as medicaments
    2.
    发明授权
    Substituted piperazine derivatives, the preparation thereof and their use as medicaments 有权
    取代的哌嗪衍生物,其制备及其作为药物的用途

    公开(公告)号:US06821967B2

    公开(公告)日:2004-11-23

    申请号:US10168486

    申请日:2002-10-09

    IPC分类号: A61K31496

    CPC分类号: C07D295/145 C07C2603/18

    摘要: The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.

    摘要翻译: 本发明涉及通式为R a,R b,R c,R f,R g,X,m和n的取代哌嗪衍生物,其权利要求1中定义为其异构体和盐,特别是其生理上可接受的盐,它们是有用的抑制剂 微粒体甘油三酯转移蛋白(MTP),含有这些化合物的药物及其用途以及其制备方法。