专利检索 ap:("Timothy D. Harris" OR "Philip R. Buzby" OR "Mirna Jarosz" OR "Jaime Gill" OR "Howard Weiss" OR "Stanley N. Lapidus") AND inv:"Jaime Gill" 第 1 页

1.

发明申请
OPTICAL TRAIN AND METHOD FOR TIRF SINGLE MOLECULE DETECTION AND ANALYSIS 审中-公开
标题翻译：用于轮胎单分子检测和分析的光学训练和方法

公开(公告)号：US20080246949A1

公开(公告)日：2008-10-09

申请号：US11928727

申请日：2007-10-30

申请人： Timothy D. Harris , Philip R. Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley N. Lapidus

发明人： Timothy D. Harris , Philip R. Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley N. Lapidus

IPC分类号： G01J3/00 , G01N21/00 , G01J3/30

CPC分类号： G01N21/645 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/552 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G02B21/16 , G02B2207/113

摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

摘要翻译： 一方面，本发明涉及一种使用全内反射来分析单个分子的存在的装置。在一个实施方案中，用于单分子分析的装置包括具有位于其上的样品的载体; 两个不同波长的光源，用于通过全内反射物镜将光引导到样品上的准直器; 接收器，用于响应于光接收由样品中的单个分子产生的荧光发射; 以及用于检测荧光发射中的每个波长的检测器。在另一个实施例中，该装置还包括聚焦激光器，用于保持物体在样本上的焦点。

2.

发明申请
OPTICAL TRAIN AND METHOD FOR TIRF SINGLE MOLECULE DETECTION AND ANALYSIS 审中-公开

公开(公告)号：US20080087826A1

公开(公告)日：2008-04-17

申请号：US11928715

申请日：2007-10-30

申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus

发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus

IPC分类号： G01J5/02 , G01T1/16

CPC分类号： G01N21/648 , C12Q1/6869 , G01N21/6458 , G01N2021/6419 , G02B2207/113 , C12Q2565/102 , C12Q2563/107 , C12Q2523/313

摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

3.

发明申请
Optical Train and Method for TIRF Single Molecule Detection and Analysis 审中-公开
标题翻译：光学列车及TIRF单分子检测与分析方法

公开(公告)号：US20080088823A1

公开(公告)日：2008-04-17

申请号：US11849088

申请日：2007-08-31

申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus

发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus

IPC分类号： G01J3/00 , G01N21/00 , G01N21/55

CPC分类号： G01N21/645 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/552 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G02B21/16 , G02B2207/113

摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

摘要翻译： 一方面，本发明涉及一种使用全内反射来分析单个分子的存在的装置。在一个实施方案中，用于单分子分析的装置包括具有位于其上的样品的载体; 两个不同波长的光源，用于通过全内反射物镜将光引导到样品上的准直器; 接收器，用于响应于光接收由样品中的单个分子产生的荧光发射; 以及用于检测荧光发射中的每个波长的检测器。在另一个实施例中，该装置还包括聚焦激光器，用于保持物体在样本上的焦点。

4.

发明申请
Optical train and method for TIRF single molecule detection and analysis 审中-公开
标题翻译：光学列车和TIRF单分子检测与分析方法

公开(公告)号：US20070070349A1

公开(公告)日：2007-03-29

申请号：US11234420

申请日：2005-09-23

申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus

发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus

IPC分类号： G01N21/64

CPC分类号： G01N21/645 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/552 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G02B21/16 , G02B2207/113

摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.

摘要翻译： 一方面，本发明涉及一种使用全内反射来分析单个分子的存在的装置。在一个实施方案中，用于单分子分析的装置包括具有位于其上的样品的载体; 两个不同波长的光源，用于通过全内反射物镜将光引导到样品上的准直器; 接收器，用于响应于光接收由样品中的单个分子产生的荧光发射; 以及用于检测荧光发射中的每个波长的检测器。在另一个实施例中，该装置还包括聚焦激光器，用于保持物体在样本上的焦点。