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1.
公开(公告)号:US07671059B2
公开(公告)日:2010-03-02
申请号:US11541462
申请日:2006-09-28
申请人: Timothy D. Machajewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
发明人: Timothy D. Machajewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
IPC分类号: A61K31/519 , A61K31/5355 , C07D471/04 , C07D487/04 , C07D413/06 , A61P35/00
CPC分类号: C07D211/86 , C07D471/04
摘要: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物,其立体异构体,互变异构体,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物,单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法,用于预防 或治疗细胞增殖,病毒,自身免疫,心血管和中枢神经系统疾病。
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2.
公开(公告)号:US20100004237A1
公开(公告)日:2010-01-07
申请号:US12462302
申请日:2009-07-31
申请人: Timothy D. Machakewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Baoqing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
发明人: Timothy D. Machakewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Baoqing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
IPC分类号: C07D471/04 , A61K31/5377 , A61K31/497 , A61K31/519
CPC分类号: C07D211/86 , C07D471/04
摘要: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物,其立体异构体,互变异构体,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物,单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法,用于预防 或治疗细胞增殖,病毒,自身免疫,心血管和中枢神经系统疾病。
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公开(公告)号:US20070027150A1
公开(公告)日:2007-02-01
申请号:US11404372
申请日:2006-04-14
申请人: Cornelia Bellamacina , Abran Costales , Brandon Doughan , Susan Fong , Zhenhai Gao , Thomas Hendrickson , Barry Levine , Xiaodong Lin , Timothy Machajewski , Christopher McBride , William Antonios-McCrea , Maureen McKenna , Kris Mendenhall , Alice Rico , Cynthia Shafer , X. Wang , Yi Xia , Yasheen Zhou
发明人: Cornelia Bellamacina , Abran Costales , Brandon Doughan , Susan Fong , Zhenhai Gao , Thomas Hendrickson , Barry Levine , Xiaodong Lin , Timothy Machajewski , Christopher McBride , William Antonios-McCrea , Maureen McKenna , Kris Mendenhall , Alice Rico , Cynthia Shafer , X. Wang , Yi Xia , Yasheen Zhou
IPC分类号: A61K31/5377 , A61K31/517 , C07D413/02 , C07D403/02
CPC分类号: C07D401/14 , C07D239/84 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/12 , C07D417/14
摘要: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.
摘要翻译: 2-氨基 - 喹唑啉-5-酮化合物,立体异构体,互变异构体,药用盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物,单独或与至少一种另外的治疗剂组合。 将2-氨基 - 喹唑啉-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。
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公开(公告)号:US20100003246A1
公开(公告)日:2010-01-07
申请号:US12383035
申请日:2009-03-19
申请人: Zilin Hunag , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
发明人: Zilin Hunag , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
IPC分类号: A61K31/444 , C07D401/14 , C07D403/14 , C07D471/04 , A61K31/506 , A61K31/437 , A61P35/00 , A61K31/4545 , A61K31/7068 , A61K31/505 , A61K33/24 , A61K39/395
CPC分类号: C07D498/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译: 提供了新的取代的杂环化合物,含有它们的组合物,以及使用它们来抑制Raf激酶活性的方法。 新化合物和组合物可以单独使用或与至少一种另外的药物组合使用,用于治疗Raf激酶介导的病症,例如癌症。
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公开(公告)号:US20130210818A1
公开(公告)日:2013-08-15
申请号:US13396339
申请日:2012-02-14
申请人: Zilin Huang , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
发明人: Zilin Huang , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
IPC分类号: A61K31/444 , A61K31/506 , C07D403/14 , C07D405/14 , A61K31/4439 , C07D417/14 , C07D471/04 , C07D413/14 , A61K31/496 , C07D487/04 , A61K31/4985 , C07D498/04 , A61K31/5383 , A61K31/4709 , A61K31/5377 , A61P35/00 , C07D401/14
CPC分类号: A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04 , A61K2300/00
摘要: New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译: 提供了新的取代的杂环化合物,含有它们的组合物,以及使用它们来抑制Raf激酶活性的方法。 新化合物和组合物可以单独使用或与至少一种另外的药物组合使用,用于治疗Raf激酶介导的病症,例如癌症。
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公开(公告)号:US08865732B2
公开(公告)日:2014-10-21
申请号:US13396339
申请日:2012-02-14
申请人: Zilin Huang , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
发明人: Zilin Huang , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
IPC分类号: A61K31/505 , C07D241/02
CPC分类号: A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04 , A61K2300/00
摘要: New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译: 提供了新的取代的杂环化合物,含有它们的组合物,以及使用它们来抑制Raf激酶活性的方法。 新化合物和组合物可以单独使用或与至少一种另外的药物组合使用,用于治疗Raf激酶介导的病症,例如癌症。
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公开(公告)号:US08129394B2
公开(公告)日:2012-03-06
申请号:US12383035
申请日:2009-03-19
申请人: Zilin Hunag , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
发明人: Zilin Hunag , Jeff Jin , Timothy Machajewski , William R. Antonios-McCrea , Maureen McKenna , Daniel Poon , Paul A. Renhowe , Martin Sendzik , Cynthia Shafer , Aaron Smith , Yongjin Xu , Qiong Zhang , Zheng Chen
IPC分类号: A61K31/4965 , A61K31/505 , A01N43/54 , C07D403/00 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: C07D498/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要: Novel imidazole compounds of the general formula are disclosed, wherein R1 and R2 comprise heteroaryl groups. These compounds and compositions containing them are useful in methods to treat Raf kinase-mediated disorders such as cancer.
摘要翻译: 公开了通式的新型咪唑化合物,其中R 1和R 2包含杂芳基。 这些含有它们的化合物和组合物可用于治疗Raf激酶介导的疾病如癌症的方法。
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