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公开(公告)号:US20070105864A1
公开(公告)日:2007-05-10
申请号:US11598188
申请日:2006-11-08
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui , Praveen Tadikonda
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , David Parry , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui , Praveen Tadikonda
IPC分类号: A61K31/498
CPC分类号: A61K31/4985 , A61K31/498
摘要: The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译: 本发明提供使用咪唑并[1,2-a]吡嗪化合物抑制选自AKT,检查点激酶,极光激酶,Pim-1激酶和酪氨酸激酶的蛋白激酶的方法以及治疗,预防,抑制 ,或使用这些化合物改善与蛋白激酶相关的一种或多种疾病。
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2.
公开(公告)号:US20060106023A1
公开(公告)日:2006-05-18
申请号:US11272392
申请日:2005-11-10
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , M. Siddiqui
IPC分类号: A61K31/506 , A61K31/498 , C07D487/02
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并[1,2-a]吡嗪化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20070117804A1
公开(公告)日:2007-05-24
申请号:US11598186
申请日:2006-11-08
申请人: Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , Kamil Paruch , Timothy Guzi , Michael Dwyer , M. Siddiqui , Praveen Tadikonda
发明人: Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , Kamil Paruch , Timothy Guzi , Michael Dwyer , M. Siddiqui , Praveen Tadikonda
IPC分类号: A61K31/498 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或检查点激酶的抑制剂,制备此类化合物的方法,包含一种或多种此类化合物的药物组合物,制备药物制剂的方法,包括一种或多种 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。
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4.
公开(公告)号:US20070072882A1
公开(公告)日:2007-03-29
申请号:US11543182
申请日:2006-10-04
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , M. Siddiqui , Panduranga Reddy , David Belanger , Blake Hamann , Patrick Curran
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , M. Siddiqui , Panduranga Reddy , David Belanger , Blake Hamann , Patrick Curran
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04
摘要: In its many embodiments, the present invention provides a class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases (CDKs), methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类作为细胞周期蛋白依赖性激酶(CDK)抑制剂的吡唑并[1,5-a]嘧啶化合物,制备这些化合物的方法,含有一种或多种这类化合物的药物组合物,制备方法 包含一种或多种这样的化合物的药物制剂,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20060252778A1
公开(公告)日:2006-11-09
申请号:US11142601
申请日:2005-06-01
申请人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号: C07D471/02 , C07D498/02 , A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245
CPC分类号: C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂化物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-α或其组合介导的疾病或病症。
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公开(公告)号:US09360914B2
公开(公告)日:2016-06-07
申请号:US12685841
申请日:2010-01-12
CPC分类号: G06F1/26 , G06F1/3203 , G06F1/324 , G06F1/3296 , H04L43/0876 , H05K7/1498 , Y02D10/126 , Y02D10/172
摘要: A system for controlling energy usage in a server having a processor, where the system includes a memory for storing energy cost information, and a controller for determining a transaction rate for the processor. The controller is also for determining a cumulative of energy expended by the server based on the determined transaction rate for each of a number of available power level states (P-states) for operation of the processor, and for selecting one of the available P-states for operation of the processor based on the determined cumulative energy expended and the stored energy cost information.
摘要翻译: 一种用于控制具有处理器的服务器中的能量使用的系统,其中所述系统包括用于存储能量成本信息的存储器,以及用于确定处理器的交易速率的控制器。 控制器还用于基于用于处理器的操作的多个可用功率电平状态(P状态)中的每个状态的确定的事务速率来确定由服务器消耗的能量的累积,并且用于选择可用P- 基于所确定的消耗的累积能量和存储的能量成本信息来处理处理器的状态。
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公开(公告)号:US20110173467A1
公开(公告)日:2011-07-14
申请号:US12685841
申请日:2010-01-12
CPC分类号: G06F1/26 , G06F1/3203 , G06F1/324 , G06F1/3296 , H04L43/0876 , H05K7/1498 , Y02D10/126 , Y02D10/172
摘要: A system for controlling energy usage in a server having a processor, where the system includes a memory for storing energy cost information, and a controller for determining a transaction rate for the processor. The controller is also for determining a cumulative of energy expended by the server based on the determined transaction rate for each of a number of available power level states (P-states) for operation of the processor, and for selecting one of the available P-states for operation of the processor based on the determined cumulative energy expended and the stored energy cost information.
摘要翻译: 一种用于控制具有处理器的服务器中的能量使用的系统,其中所述系统包括用于存储能量成本信息的存储器,以及用于确定处理器的交易速率的控制器。 控制器还用于基于用于处理器的操作的多个可用功率电平状态(P状态)中的每个状态的确定的事务速率来确定由服务器消耗的能量的累积,并且用于选择可用P- 基于所确定的消耗的累积能量和存储的能量成本信息来处理处理器的状态。
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8.
公开(公告)号:US08738702B1
公开(公告)日:2014-05-27
申请号:US11180212
申请日:2005-07-13
申请人: David Belanger , Sam Parker , Sarat Puthenpura , Wenjie Zhao
发明人: David Belanger , Sam Parker , Sarat Puthenpura , Wenjie Zhao
IPC分类号: G06F15/16
CPC分类号: G06Q30/0261 , G06F15/16
摘要: The disclosure provides a method and corresponding system for personalizing and disbursing content material in an automated fashion based on differing characteristics or profiles of the recipients. The system includes a database of potential recipients with key characteristics such as location data, revenue, product ownership, customer status, tenure with the company/organization, payment status, credit rating, whether they have recently responded to other material, and the like. Dissemination media include email communications, collaterals, brochures, textual materials, image and video information, and any similar media, where the contents of the communication material is customized based on the key characteristics profiles of the recipients and driven by a set of business rules that can be adapted to fit various scenarios.
摘要翻译: 本公开提供了一种用于基于接收者的不同特征或简档以自动方式个性化和分发内容资料的方法和相应系统。 该系统包括具有关键特征的潜在接收者的数据库,例如位置数据,收入,产品所有权,客户状况,与公司/组织的任期,支付状况,信用评级,最近是否对其他资料进行了回应等。 传播媒体包括电子邮件通信,抵押品,小册子,文本材料,图像和视频信息以及任何类似媒体,其中通信材料的内容基于接收者的关键特性简档来定制,并由一组业务规则驱动 可以适应各种场景。
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9.
公开(公告)号:US20120216200A1
公开(公告)日:2012-08-23
申请号:US13029843
申请日:2011-02-17
IPC分类号: G06F9/44
CPC分类号: G06F9/5094 , G06F1/206 , G06F1/3206 , G06F11/3062 , G06F11/3096 , Y02D10/16 , Y02D10/22
摘要: The disclosed embodiments provide a system that analyzes telemetry data from a computer system. During operation, the system obtains the telemetry data as a set of telemetric signals using a set of sensors in the computer system. Next, the system analyzes the telemetry data to estimate a value of a parameter associated with the computer system, wherein the parameter is at least one of a power utilization and a temperature. Finally, the system controls a subsequent value of the parameter by modulating a virtual duty cycle of a processor in the computer system based on the estimated value.
摘要翻译: 所公开的实施例提供了一种从计算机系统分析遥测数据的系统。 在操作期间,系统使用计算机系统中的一组传感器获得遥测数据作为一组遥测信号。 接下来,系统分析遥测数据以估计与计算机系统相关联的参数的值,其中该参数是功率利用率和温度中的至少一个。 最后,系统通过基于估计值调制计算机系统中的处理器的虚拟占空比来控制参数的后续值。
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公开(公告)号:US20100031365A1
公开(公告)日:2010-02-04
申请号:US12221176
申请日:2008-07-31
IPC分类号: G06F21/00
CPC分类号: H04L63/102 , G06F21/6263
摘要: A method for providing network access privacy by classifying filter parameters of a group of users who are accessing one or more network destinations. The system includes a means for collecting information from both users, and about network destinations, generating suggestions for a user regarding filter parameters, and filtering network communications of users going to network destinations. In operation, users who are accessing network destinations are prompted to choose from a selection of filter parameters. The information provided by these users is then analyzed and used to generate suggested filter parameters for other users. As users provide more information to the system about various network destinations the system is able to provide more information to users about more network destinations and thus generate more accurate filter parameter suggestions. After a user selects their filter parameters the system filters a range of information coming from the user and going out to the network destination.
摘要翻译: 一种通过对正在访问一个或多个网络目的地的一组用户的过滤器参数进行分类来提供网络访问隐私的方法。 该系统包括用于从用户和关于网络目的地收集信息的装置,为用户生成关于过滤器参数的建议,以及过滤去往网络目的地的用户的网络通信。 在操作中,提示正在访问网络目的地的用户从过滤器参数的选择中进行选择。 然后分析这些用户提供的信息,并用于为其他用户生成建议的过滤器参数。 随着用户向系统提供关于各种网络目的地的更多信息,系统能够向用户提供关于更多网络目的地的更多信息,从而生成更准确的过滤器参数建议。 用户选择过滤器参数后,系统将过滤来自用户的一系列信息,并进入网络目的地。
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