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公开(公告)号:US08546434B2
公开(公告)日:2013-10-01
申请号:US13085746
申请日:2011-04-13
申请人: Tinya Abrams , Paul Barsanti , Yu Ding , David Duhl , Wooseok Han , Cheng Hu , Yue Pan
发明人: Tinya Abrams , Paul Barsanti , Yu Ding , David Duhl , Wooseok Han , Cheng Hu , Yue Pan
IPC分类号: A61K31/44 , A61K31/54 , A61K31/445 , C07D249/08 , C07D413/02
CPC分类号: C07D403/12 , A61K31/4196 , A61K31/5377 , A61K45/06 , C07D207/10 , C07D249/08 , C07D405/12 , C07D405/14 , C07D413/14
摘要: The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.
摘要翻译: 本发明提供式I的三唑化合物:如本文进一步描述的。 本发明还提供了包含治疗有效量的式I化合物的药物组合物,以及治疗在哺乳动物患者中至少部分地由KSP介导的病症的方法,包括向需要这种治疗的哺乳动物患者施用 治疗有效量的式I化合物。
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公开(公告)号:US20140056880A1
公开(公告)日:2014-02-27
申请号:US14012167
申请日:2013-08-28
申请人: Tinya Abrams , Paul Barsanti , Yu Ding , David Duhl , Wooseok Han , Cheng Hu , Yue Pan
发明人: Tinya Abrams , Paul Barsanti , Yu Ding , David Duhl , Wooseok Han , Cheng Hu , Yue Pan
IPC分类号: C07D403/12 , C07D413/14 , C07D207/10 , A61K31/5377 , A61K45/06 , C07D405/14 , A61K31/4196
CPC分类号: C07D403/12 , A61K31/4196 , A61K31/5377 , A61K45/06 , C07D207/10 , C07D249/08 , C07D405/12 , C07D405/14 , C07D413/14
摘要: The present invention provides triazole compounds of Formula I: as further described herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, and a method of treating a disorder mediated, at least in part, by KSP in a mammalian patient comprising administering to a mammalian patient in need of such treatment a therapeutically effective amount of a compound of Formula I.
摘要翻译: 本发明提供式I的三唑化合物:如本文进一步描述的。 本发明还提供了包含治疗有效量的式I化合物的药物组合物,以及治疗在哺乳动物患者中至少部分地由KSP介导的病症的方法,包括向需要这种治疗的哺乳动物患者施用 治疗有效量的式I化合物。
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公开(公告)号:US09242996B2
公开(公告)日:2016-01-26
申请号:US14527328
申请日:2014-10-29
申请人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Jeff Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
发明人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Jeff Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC分类号: C07D213/73 , C07D401/06 , C07D403/06 , C07D498/04 , A61K31/4436 , A61K31/4545 , A61K31/4439 , A61K31/4965 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D401/12
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
摘要翻译: 本发明提供式(I)的化合物或其盐; 和这些化合物的治疗用途。 本发明还提供包含这些化合物的药物组合物,以及包含这些化合物与治疗性助剂的组合物。
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公开(公告)号:US09763937B2
公开(公告)日:2017-09-19
申请号:US14964057
申请日:2015-12-09
申请人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
发明人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC分类号: C07D241/02 , A61K31/4965 , A61K31/497 , A61K31/4433 , A61K31/44 , A61K31/4436 , A61K31/5355
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号:US20120225061A1
公开(公告)日:2012-09-06
申请号:US13410203
申请日:2012-03-01
申请人: Matthew Burger , Yu Ding , Wooseok Han , Gisele Nishiguchi , Alice Rico , Robert Lowell Simmons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
发明人: Matthew Burger , Yu Ding , Wooseok Han , Gisele Nishiguchi , Alice Rico , Robert Lowell Simmons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
IPC分类号: A61K31/444 , A61K31/506 , A61K31/497 , C07D413/14 , A61K31/5377 , A61K31/4745 , A61K31/7068 , A61K31/513 , A61K31/704 , A61K31/519 , A61K33/24 , A61K31/664 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/00 , A61P1/00 , C07D401/12
CPC分类号: A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/395 , A61K45/06 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要: The present invention provides a compound of formula (I): as further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.
摘要翻译: 本发明提供式(I)化合物:如本文进一步描述的,及其药学上可接受的盐,对映异构体,旋转异构体,互变异构体或外消旋体。 还提供了使用式I化合物治疗PIM激酶介导的疾病或病症的方法和包含这些化合物的药物组合物。
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公开(公告)号:US20130109682A1
公开(公告)日:2013-05-02
申请号:US13807993
申请日:2011-07-04
申请人: Matthew Burger , Yu Ding , Wooseok Han , Mika Lindvall , Gisele A. Nishiguchi , Alice Rico , Aaron Smith , Huw Tanner , Lifeng Wan
发明人: Matthew Burger , Yu Ding , Wooseok Han , Mika Lindvall , Gisele A. Nishiguchi , Alice Rico , Aaron Smith , Huw Tanner , Lifeng Wan
IPC分类号: C07D417/14 , A61K31/444 , A61K45/06 , A61K31/506 , A61K31/501 , A61K31/541 , C07D405/14 , A61K31/497
CPC分类号: C07D417/14 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/541 , A61K45/06 , C07D405/14 , C07D407/04 , C07D407/14 , C07D491/04 , A61K2300/00
摘要: The present invention provides certain compounds of Formula (I): and pharmaceutically acceptable salts thereof, as further described herein. Also provided are formulations comprising compounds of formula I, and a method to use such compounds for treating a disease or condition mediated by Provirus Integration of Maloney Kinase (PIM Kinase), GSK3, PKC, KDR, PDGFRa, FGFR3, FLT3, or cABL.
摘要翻译: 本发明提供了本文进一步描述的某些式(I)化合物及其药学上可接受的盐。 还提供了包含式I化合物的制剂和使用这些化合物治疗由Maloney激酶(PIM激酶),GSK3,PKC,KDR,PDGFRa,FGFR3,FLT3或cABL的Provirus整合介导的疾病或病症的方法。
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公开(公告)号:US20140228363A1
公开(公告)日:2014-08-14
申请号:US14258764
申请日:2014-04-22
申请人: Matthew Burger , Yu Ding , Wooseok Han , Gisele Nishiguchi , Alice Rico , Robert Lowell Simons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
发明人: Matthew Burger , Yu Ding , Wooseok Han , Gisele Nishiguchi , Alice Rico , Robert Lowell Simons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
IPC分类号: C07D401/12 , A61K45/06 , A61K31/506 , C07D417/12 , A61K31/4439 , C07D409/14 , C07D417/14 , C07D405/14 , C07D401/14 , A61K31/5377 , C07D413/14 , A61K31/444 , A61K31/497
CPC分类号: A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/395 , A61K45/06 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要: The present invention provides a compound of formula (I): as further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.
摘要翻译: 本发明提供式(I)化合物:如本文进一步描述的,及其药学上可接受的盐,对映异构体,旋转异构体,互变异构体或外消旋体。 还提供了使用式I化合物治疗PIM激酶介导的疾病或病症的方法和包含这些化合物的药物组合物。
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公开(公告)号:US08748626B2
公开(公告)日:2014-06-10
申请号:US13640561
申请日:2011-04-13
申请人: Paul A. Barsanti , Yu Ding , Wooseok Han
发明人: Paul A. Barsanti , Yu Ding , Wooseok Han
IPC分类号: A61K31/422 , A61K31/427 , C07D277/28 , C07D277/30 , C07D263/32 , C07D413/12 , C07D417/12 , C07D417/14
CPC分类号: A61K31/427 , A61K31/422 , A61K31/426 , A61K31/437 , A61K45/06 , C07D263/32 , C07D277/28 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Disclosed are new substituted oxazole and thiazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof:
摘要翻译: 公开了式(I)的新的取代的恶唑和噻唑化合物及其药学上可接受的盐,酯或前药,衍生物的组合物和药学上可接受的载体,及其用途:
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公开(公告)号:US20130224186A1
公开(公告)日:2013-08-29
申请号:US13640561
申请日:2011-04-13
申请人: Paul A. Barsanti , Yu Ding , Wooseok Han
发明人: Paul A. Barsanti , Yu Ding , Wooseok Han
IPC分类号: A61K31/427 , A61K31/437 , C07D417/14 , A61K45/06 , A61K31/426 , C07D413/12 , A61K31/422 , C07D263/32 , C07D471/04 , C07D277/28
CPC分类号: A61K31/427 , A61K31/422 , A61K31/426 , A61K31/437 , A61K45/06 , C07D263/32 , C07D277/28 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Disclosed are new substituted oxazole and thiazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof:
摘要翻译: 公开了式(I)的新的取代的恶唑和噻唑化合物及其药学上可接受的盐,酯或前药,衍生物的组合物和药学上可接受的载体,及其用途:
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公开(公告)号:US09079889B2
公开(公告)日:2015-07-14
申请号:US14081132
申请日:2013-11-15
申请人: Matthew T. Burger , Wooseok Han , Jiong Lan , Gisele Nishiguchi
发明人: Matthew T. Burger , Wooseok Han , Jiong Lan , Gisele Nishiguchi
IPC分类号: A61K31/4418 , C07D401/14 , C07D401/12 , A61K31/444 , A61K31/4545 , A61K45/06 , C07D213/81
CPC分类号: C07D213/81 , A61K31/4418 , A61K31/444 , A61K31/4545 , A61K45/06 , C07D401/12 , C07D401/14
摘要: New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译: 提供了新的化合物,组合物和方法抑制Provirus与人或动物受试者中与肿瘤发生相关的Maloney激酶(PIM激酶)活性的整合。 在某些实施方案中,化合物和组合物有效抑制至少一种PIM激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用,用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症,例如癌症。
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