-
公开(公告)号:US20120142914A1
公开(公告)日:2012-06-07
申请号:US13370768
申请日:2012-02-10
申请人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号: C07D413/12 , C07D307/92 , C07D405/08 , C07D317/72 , C07C269/06
CPC分类号: C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
-
公开(公告)号:US20120302745A1
公开(公告)日:2012-11-29
申请号:US13564966
申请日:2012-08-02
申请人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号: C07C269/06 , C07D307/92 , C07D405/08 , C07D317/72 , C07D413/12
CPC分类号: C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要翻译: 本申请公开了一种用于合成烟肼类似物的新方法,以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径,手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序:
-
公开(公告)号:US08273790B2
公开(公告)日:2012-09-25
申请号:US13370768
申请日:2012-02-10
申请人: Tiruvettipuram K. Thiruvengadam , Anantha Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人: Tiruvettipuram K. Thiruvengadam , Anantha Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号: A61K31/335
CPC分类号: C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要翻译: 本申请公开了一种用于合成烟肼类似物的新方法,以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径,手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序:
-
公开(公告)号:US20100267947A1
公开(公告)日:2010-10-21
申请号:US12827000
申请日:2010-06-30
申请人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号: C07D413/12 , C07D317/72 , C07C269/06 , C07D307/92 , C07D405/08
CPC分类号: C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要翻译: 本申请公开了一种用于合成烟肼类似物的新方法,以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径,手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序:
-
公开(公告)号:US07772276B2
公开(公告)日:2010-08-10
申请号:US11330521
申请日:2006-01-12
申请人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap-Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人: Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap-Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号: A61K31/34
CPC分类号: C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要翻译: 本申请公开了一种用于合成烟肼类似物的新方法,以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径,手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序:
-
公开(公告)号:US08138180B2
公开(公告)日:2012-03-20
申请号:US12827000
申请日:2010-06-30
申请人: Tiruvettipuram K. Thiruvengadam , Anantha Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人: Tiruvettipuram K. Thiruvengadam , Anantha Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号: A61K31/535
CPC分类号: C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
-
公开(公告)号:US5442047A
公开(公告)日:1995-08-15
申请号:US138558
申请日:1993-10-15
申请人: Chou-Hong Tann , Tiruvettipuram K. Thiruvengadam , John S. Chiu , Cesar Colon , Michael D. Green
发明人: Chou-Hong Tann , Tiruvettipuram K. Thiruvengadam , John S. Chiu , Cesar Colon , Michael D. Green
IPC分类号: C07D277/64 , C07D277/74 , C07H15/236 , C07H15/26 , C07H1/00
CPC分类号: C07D277/74 , C07D277/64 , C07H15/236 , C07H15/26
摘要: An improved process for converting gentamicin B to isepamicin comprising forming 3,6'-di-N-formylgentamicin B, acylating the 1-amino group with an N-protected (S)-isoserine compound and removing all the blocking groups under conditions which result in high yields of isepamicin. A novel formylating agent, 2-formylmercaptobenzothiazole, and intermediate compounds are also disclosed.
摘要翻译: 一种将庆大霉素B转化为异环磷酰胺的改进方法,包括形成3,6'-二-N-甲酰基阿霉素B,用N-保护的(S) - 异丝氨酸化合物酰化1-氨基,并在产生的条件下除去所有的封闭基团 在高产量的异环霉素。 还公开了一种新型甲酰化剂,2-甲酰巯基苯并噻唑和中间体化合物。
-
公开(公告)号:US5539121A
公开(公告)日:1996-07-23
申请号:US442084
申请日:1995-05-16
申请人: Chou-Hong Tann , Tiruvettipuram K. Thiruvengadam , John S. Chiu , Cesar Colon , Michael D. Green
发明人: Chou-Hong Tann , Tiruvettipuram K. Thiruvengadam , John S. Chiu , Cesar Colon , Michael D. Green
IPC分类号: C07D277/64 , C07D277/74 , C07H15/236 , C07H15/26 , C07D417/00
CPC分类号: C07D277/74 , C07D277/64 , C07H15/236 , C07H15/26
摘要: There is disclosed a novel formylating agent, 2-formylmercaptobenzothiazole.
摘要翻译: 公开了一种新的甲酰化剂2-甲酰巯基苯并噻唑。
-
公开(公告)号:US06992220B2
公开(公告)日:2006-01-31
申请号:US10867601
申请日:2004-06-15
申请人: Minzhang Chen , Michael D. Green , Fucheng Zhang
发明人: Minzhang Chen , Michael D. Green , Fucheng Zhang
IPC分类号: C07C233/05 , C07C271/14
CPC分类号: C07C271/16 , C07C237/14 , C07C271/22 , C07C2601/04
摘要: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
-
公开(公告)号:US4817091A
公开(公告)日:1989-03-28
申请号:US52094
申请日:1987-05-19
申请人: James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
发明人: James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
IPC分类号: G06F11/18 , G06F1/26 , G06F5/06 , G06F7/78 , G06F9/46 , G06F9/52 , G06F11/00 , G06F11/10 , G06F11/16 , G06F11/20 , G06F12/08 , G06F12/10 , G06F12/12 , G06F12/14 , G06F13/00 , G06F13/12 , G06F13/20 , G06F13/28 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173
CPC分类号: G06F7/78 , G06F11/10 , G06F11/1044 , G06F11/2007 , G06F11/2015 , G06F11/2023 , G06F11/2035 , G06F11/2043 , G06F11/2097 , G06F12/08 , G06F12/14 , G06F12/1458 , G06F13/122 , G06F13/20 , G06F13/287 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173 , G06F5/06
摘要: In a multiprocessor system interconnected by a bus structure that provides communication and information transfers between the processor modules of the system, each processor broadcasts a central message to all the other processors of the system on a periodic basis. A processor module not receiving the control message from a sending processor module will assume the sending processor module has failed, and operate to take over the task of the failed processor module.
摘要翻译: 在通过提供系统的处理器模块之间的通信和信息传输的总线结构互连的多处理器系统中,每个处理器周期性地向系统的所有其他处理器广播中央消息。 没有从发送处理器模块接收控制消息的处理器模块将假定发送处理器模块已经失败,并且操作以接管故障处理器模块的任务。
-
-
-
-
-
-
-
-
-