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    Stent delivery system and method of use
    1.
    发明授权
    Stent delivery system and method of use 失效
    支架输送系统及使用方法

    公开(公告)号：US06409751B1

    公开(公告)日：2002-06-25

    申请号：US09710884

    申请日：2000-11-14

    申请人： Todd A. Hall ,  Greg R. Furnish ,  Simon M. Furnish ,  Scott J. Wolf ,  Peter J. Wilk ,  David Y. Phelps ,  Vincent Pompili

    发明人： Todd A. Hall ,  Greg R. Furnish ,  Simon M. Furnish ,  Scott J. Wolf ,  Peter J. Wilk ,  David Y. Phelps ,  Vincent Pompili

    IPC分类号： A61F206

    CPC分类号： A61F2/958 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2018/00392 ,  A61F2/2493 ,  A61F2/86 ,  A61M25/10 ,  A61M25/1006 ,  A61M2025/0096 ,  A61M2025/0197 ,  A61M2025/1095 ,  Y10S623/903

    摘要： Described herein are various methods and apparatuses for delivering stents and other devices into the myocardium of a patient. One preferred stent delivery system provides access to the insertion site in the myocardium by advancing a delivery catheter through a blockage in a coronary artery, or around the blockage through a coronary vein or through a channel or tunnel formed around the blockage. In one embodiment, once the distal end of the delivery catheter is adjacent the myocardium, an angled bend is created in the catheter by actuating expandable steering guides mounted to the catheter which cooperate with the walls of the blood vessel to cause the catheter to turn. Then, a guidewire is advanced through the delivery catheter and into the myocardium. In another embodiment, a tip-deflecting pull wire extends from the distal end of the delivery catheter which may be actuated to turn towards and then inserted into the myocardium. In another embodiment, an exit port facing the insertion site is provided within the catheter or a balloon mounted on the catheter so that a guidewire may be directed through a lumen and out the exit port into the myocardium. Once the guidewire punctures into the myocardium, the guidewire is anchored using barbs, balloons or other actuatable members to secure the guidewire to the myocardium. Subsequently, using a push-pull mechanism, stents and other medical devices can be advanced over the guidewire into the myocardium.

    摘要翻译： 这里描述了用于将支架和其他装置输送到患者的心肌中的各种方法和装置。 一个优选的支架递送系统通过使输送导管通过冠状动脉阻塞或通过冠状静脉或通过在阻塞周围形成的通道或隧道周围的阻塞来推进进入心肌中的插入部位。 在一个实施例中，一旦输送导管的远端与心肌相邻，则通过致动安装到导管的可扩展转向引导件，在导管中产生成角度的弯曲部，其与血管的壁配合以使导管转动。 然后，导丝通过输送导管进入心肌。 在另一个实施例中，尖端偏转拉线从输送导管的远端延伸，可以被致动以转向然后插入心肌。 在另一个实施例中，面向插入部位的出口端设置在导管内或安装在导管上的球囊上，使得导丝可以被引导通过内腔并离开出口进入心肌。 一旦导丝穿刺入心肌，就使用倒刺，气球或其他可致动部件来固定导丝，以将导丝固定到心肌。 随后，使用推拉机构，支架和其他医疗装置可以在导丝上前进进入心肌。

    Stent delivery system and method of use
    2.
    发明授权
    Stent delivery system and method of use 失效
    支架输送系统及使用方法

    公开(公告)号：US06196230B1

    公开(公告)日：2001-03-06

    申请号：US09150181

    申请日：1998-09-10

    申请人： Todd A. Hall ,  Greg R. Furnish ,  Simon M. Furnish ,  Scott J. Wolf ,  Peter J. Wilk ,  David Y. Phelps ,  Vincent Pompili

    发明人： Todd A. Hall ,  Greg R. Furnish ,  Simon M. Furnish ,  Scott J. Wolf ,  Peter J. Wilk ,  David Y. Phelps ,  Vincent Pompili

    IPC分类号： A61B1900

    CPC分类号： A61F2/958 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2018/00392 ,  A61F2/2493 ,  A61F2/86 ,  A61M25/10 ,  A61M25/1006 ,  A61M2025/0096 ,  A61M2025/0197 ,  A61M2025/1095 ,  Y10S623/903

    摘要： Described herein are various methods and apparatuses for delivering stents and other devices into the myocardium of a patient. One preferred stent delivery system provides access to the insertion site in the myocardium by advancing a delivery catheter through a blockage in a coronary artery, or around the blockage through a coronary vein or through a channel or tunnel formed around the blockage. In one embodiment, once the distal end of the delivery catheter is adjacent the myocardium, an angled bend is created in the catheter by actuating expandable steering guides mounted to the catheter which cooperate with the walls of the blood vessel to cause the catheter to turn. Then, a guidewire is advanced through the delivery catheter and into the myocardium. In another embodiment, a tip-deflecting pull wire extends from the distal end of the delivery catheter which may be actuated to turn towards and then inserted into the myocardium. In another embodiment, an exit port facing the insertion site is provided within the catheter or a balloon mounted on the catheter so that a guidewire may be directed through a lumen and out the exit port into the myocardium. Once the guidewire punctures into the myocardium, the guidewire is anchored using barbs, balloons or other actuatable members to secure the guidewire to the myocardium. Subsequently, using a push-pull mechanism, stents and other medical devices can be advanced over the guidewire into the myocardium.

    摘要翻译： 这里描述了用于将支架和其他装置输送到患者的心肌中的各种方法和装置。 一个优选的支架递送系统通过使输送导管通过冠状动脉阻塞或通过冠状静脉或通过在阻塞周围形成的通道或隧道周围的阻塞来推进进入心肌中的插入部位。 在一个实施例中，一旦输送导管的远端与心肌相邻，则通过致动安装到导管的可扩展转向引导件，在导管中产生成角度的弯曲部，其与血管的壁配合以使导管转动。 然后，导丝通过输送导管进入心肌。 在另一个实施例中，尖端偏转拉线从输送导管的远端延伸，可以被致动以转向然后插入心肌。 在另一个实施例中，面向插入部位的出口端设置在导管内或安装在导管上的球囊上，使得导丝可以被引导通过内腔并离开出口进入心肌。 一旦导丝穿刺入心肌，就使用倒刺，气球或其他可致动部件来固定导丝，以将导丝固定到心肌。 随后，使用推拉机构，支架和其他医疗装置可以在导丝上前进进入心肌。

    Delivery methods for left ventricular conduit
    3.
    发明授权
    Delivery methods for left ventricular conduit 失效

    公开(公告)号：US06694983B2

    公开(公告)日：2004-02-24

    申请号：US10092916

    申请日：2002-03-08

    申请人： Scott J. Wolf ,  Peter J. Wilk ,  Vincent Pompili

    发明人： Scott J. Wolf ,  Peter J. Wilk ,  Vincent Pompili

    IPC分类号： A61B1900

    CPC分类号： A61M25/0147 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/22071 ,  A61B2017/22095 ,  A61B2018/00392 ,  A61F2/2493 ,  A61F2/86 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0152 ,  A61M25/0155 ,  A61M25/0194 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0096 ,  A61M2025/0197 ,  A61M2025/1095 ,  A61M2025/1097 ,  A61M2210/125

    摘要： Described herein are various methods and apparatuses for delivering stents or conduits and other devices into the myocardium of a patient. One preferred stent delivery system provides access to the insertion site in the myocardium by advancing a delivery catheter through a blockage in a coronary artery, or around the blockage through a coronary vein or through a channel or tunnel formed around the blockage. In one embodiment, once the distal end of the delivery catheter is adjacent the myocardium, an angled bend is created in the catheter by actuating expandable steering guides mounted to the catheter which cooperate with the walls of the blood vessel to cause the catheter to turn. Then, a guidewire is advanced through the delivery catheter and into the myocardium. In another embodiment, a tip-deflecting pull wire extends from the distal end of the delivery catheter which may be actuated to turn towards and then inserted into the myocardium. In another embodiment, an exit port facing the insertion site is provided within the catheter or a balloon mounted on the catheter so that a guidewire may be directed through a lumen and out the exit port into the myocardium. Once the guidewire punctures into the myocardium, the guidewire is anchored using barbs, balloons or other actuatable members to secure the guidewire to the myocardium. Subsequently, using a push-pull mechanism, stents and other medical devices can be advanced over the guidewire into the myocardium.

    Delivery methods for left ventricular conduit
    4.
    发明授权
    Delivery methods for left ventricular conduit 失效
    输送方法为左心室导管

    公开(公告)号：US06387119B2

    公开(公告)日：2002-05-14

    申请号：US09796590

    申请日：2001-03-02

    申请人： Scott J. Wolf ,  Peter J. Wilk ,  Vincent Pompili

    发明人： Scott J. Wolf ,  Peter J. Wilk ,  Vincent Pompili

    IPC分类号： A61F206

    CPC分类号： A61M25/0147 ,  A61B2017/00247 ,  A61B2017/00252 ,  A61B2017/22071 ,  A61B2017/22095 ,  A61B2018/00392 ,  A61F2/2493 ,  A61F2/86 ,  A61F2/95 ,  A61F2/958 ,  A61M25/0152 ,  A61M25/0155 ,  A61M25/0194 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1011 ,  A61M2025/0096 ,  A61M2025/0197 ,  A61M2025/1095 ,  A61M2025/1097 ,  A61M2210/125

    摘要： Described herein are various methods and apparatuses for delivering stents or conduits and other devices into the myocardium of a patient. One preferred stent delivery system provides access to the insertion site in the myocardium by advancing a delivery catheter through a blockage in a coronary artery, or around the blockage through a coronary vein or through a channel or tunnel formed around the blockage. In one embodiment, once the distal end of the delivery catheter is adjacent the myocardium, an angled bend is created in the catheter by actuating expandable steering guides mounted to the catheter which cooperate with the walls of the blood vessel to cause the catheter to turn. Then, a guidewire is advanced through the delivery catheter and into the myocardium. In another embodiment, a tip-deflecting pull wire extends from the distal end of the delivery catheter which may be actuated to turn towards and then inserted into the myocardium. In another embodiment, an exit port facing the insertion site is provided within the catheter or a balloon mounted on the catheter so that a guidewire may be directed through a lumen and out the exit port into the:.myocardium. Once the guidewire punctures into the myocardium, the guidewire is anchored using barbs, balloons or other actuatable members to secure the guidewire to the myocardium. Subsequently, using a push-pull mechanism, stents and other medical devices can be advanced over the guidewire into the myocardium.

    摘要翻译： 本文描述了用于将支架或管道和其他装置输送到患者的心肌中的各种方法和装置。 一个优选的支架递送系统通过使输送导管通过冠状动脉阻塞或通过冠状静脉或通过在阻塞周围形成的通道或隧道周围的阻塞来推进进入心肌中的插入部位。 在一个实施例中，一旦输送导管的远端与心肌相邻，则通过致动安装到导管的可扩展转向引导件，在导管中产生成角度的弯曲部，其与血管的壁配合以使导管转动。 然后，导丝通过输送导管进入心肌。 在另一个实施例中，尖端偏转拉线从输送导管的远端延伸，可以被致动以转向然后插入心肌。 在另一个实施例中，面向插入部位的出口端口设置在导管内或安装在导管上的球囊上，使得导丝线可以被引导通过内腔并且离开出口进入心肌。 一旦导丝穿刺入心肌，就使用倒刺，气球或其他可致动部件来固定导丝，以将导丝固定到心肌。 随后，使用推拉机构，支架和其他医疗装置可以在导丝上前进进入心肌。

    Novel cell populations and uses thereof
    6.
    发明申请
    Novel cell populations and uses thereof 审中-公开
    新型细胞群及其用途

    公开(公告)号：US20090047257A1

    公开(公告)日：2009-02-19

    申请号：US11658065

    申请日：2005-07-20

    申请人： Mary J. Laughlin ,  Vincent Pompili

    发明人： Mary J. Laughlin ,  Vincent Pompili

    IPC分类号： A61K35/12 ,  C12N5/08 ,  A61P9/00

    CPC分类号： C12N5/0692 ,  A61K2035/124

    摘要： The invention provides, among other things, novel cell populations of CD133− cells. Some aspects of the invention provide endothelial generating cells (EGCs), such as, for example, CD34−CD133−CD73−CD14+CD11b+CXCR4+ cells. The invention further provides related compositions, kits and methods of isolating the novel EGC cell populations. Also provided by the invention are methods of inducing vascularization is subjects in need thereof, such as in subjects afflicted with ischemia or vascular occlusion, by administering to the subject the EGCs alone or in combination with other cell populations, polypeptides, compounds or other agents.

    摘要翻译： 本发明尤其提供了CD133细胞的新细胞群。 本发明的一些方面提供内皮生成细胞（EGC），例如CD34-CD133-CD73-CD14 + CD11b + CXCR4 +细胞。 本发明还提供分离新EGC细胞群体的相关组合物，试剂盒和方法。 本发明还提供了通过对受试者单独或与其它细胞群体，多肽，化合物或其它药剂组合给予受试者，诱导血管形成的方法是有需要的受试者，例如患有缺血或血管闭塞的受试者。