公开(公告)号：US11975069B2

公开(公告)日：2024-05-07

申请号：US17143871

申请日：2021-01-07

申请人： Massachusetts Institute of Technology ,  Tokitae LLC

发明人： Ana Jaklenec ,  William Gates ,  Philip A. Welkhoff ,  Boris Nikolic ,  Lowell L. Wood, Jr. ,  Robert S. Langer ,  Thanh Duc Nguyen ,  Stephany Yi Tzeng ,  James J. Norman ,  Kevin McHugh

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/12

CPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6093 ,  C12N2770/32634 ,  Y02A50/30

摘要： Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

公开(公告)号：US11541017B2

公开(公告)日：2023-01-03

申请号：US15484892

申请日：2017-04-11

申请人： Massachusetts Institute of Technology ,  Tokitae LLC

发明人： Ana Jaklenec ,  Xian Xu ,  Lowell L. Wood, Jr. ,  Philip A. Welkhoff ,  William Gates ,  Boris Nikolic ,  Robert S. Langer

IPC分类号： A61K9/50 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23P10/30 ,  A61K31/375 ,  A61K31/593 ,  A61K31/714 ,  A61K31/18 ,  A61K31/26 ,  A61K31/30 ,  A61K31/519 ,  A61K47/26 ,  A61K47/36 ,  A61K31/295 ,  A61K33/30 ,  A61K31/07 ,  A61K33/18 ,  A23L27/00 ,  A23L33/10 ,  A61K9/48 ,  A61K31/23 ,  A61K33/26 ,  A61K45/06

摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

公开(公告)号：US10707683B2

公开(公告)日：2020-07-07

申请号：US15715491

申请日：2017-09-26

申请人： TOKITAE LLC

发明人： Brian L. Pal ,  Roderick T. Hinman ,  Shieng Liu ,  Jennifer Ezu Hu ,  Fridrik Larusson ,  Fong-Li Chou ,  Nels R. Peterson ,  Lowell L. Wood, Jr.

IPC分类号： G05D3/00 ,  H02J3/38 ,  H02S50/10 ,  H02J1/14 ,  G06Q50/06 ,  H02S40/38 ,  F25B49/00 ,  G05F1/67 ,  H02J3/14 ,  H02S50/00 ,  H02J7/35 ,  G05B19/04

摘要： Generally, this disclosure relates to methods of prioritizing or directing available power to a main device, such as a temperature-stabilized and/or temperature-controlled storage container. In an embodiment, the method may include measuring electrical power available from a solar photovoltaic module array that is electrically coupled to the main device, and modulating the electrical power drawn by the main device based on the available electrical power. Available power unused by the main device may be diverted to one or more secondary devices.

公开(公告)号：US09657982B2

公开(公告)日：2017-05-23

申请号：US14454899

申请日：2014-08-08

申请人： Tokitae LLC

发明人： Fong-Li Chou ,  Philip A. Eckhoff ,  Lawrence Morgan Fowler ,  Fridrik Larusson ,  Shieng Liu ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr.

IPC分类号： F25D23/12 ,  F25D17/04 ,  F25D29/00 ,  B01D53/26 ,  F25D23/00 ,  A61J1/03

CPC分类号： F25D17/042 ,  A61J1/03 ,  A61J2200/40 ,  A61J2200/42 ,  A61J2200/44 ,  A61J2200/50 ,  A61J2200/72 ,  B01D53/26 ,  F25D23/00 ,  F25D29/00 ,  F25D2400/02 ,  F25D2400/12 ,  F25D2700/12

摘要： In some embodiments, a medicinal storage container includes: a desiccant unit including external walls forming a gas-impermeable barrier around an interior desiccant region and including an aperture; a heating element; a controller operably attached to the heating element; a cooling unit; a compressor system including at least one evaporator coil unit, the compressor operably connected to the controller; a vapor conduit, the vapor conduit attached to a the desiccant unit at a first end, the vapor conduit attached to the evaporative cooling unit at a second end, the vapor conduit forming an internal, gas-impermeable passageway between the desiccant unit and the cooling unit; a vapor control unit attached to the vapor conduit and operably attached to the controller; and a medicinal storage unit including external walls encircling a medicinal storage region including a temperature sensor operably connected to the controller.

公开(公告)号：US09447995B2

公开(公告)日：2016-09-20

申请号：US14098886

申请日：2013-12-06

申请人： Tokitae LLC

发明人： Jonathan Bloedow ,  Ryan Calderon ,  Michael Friend ,  David Gasperino ,  William Gates ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Shieng Liu ,  Nathan P. Myhrvold ,  Nathan John Pegram ,  David Keith Piech ,  Shannon Weise Stone ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, Jr. ,  Ozgur Emek Yildirim

IPC分类号： F25B21/02 ,  F25B21/04 ,  B65D81/38 ,  F25B29/00 ,  F25D3/00

CPC分类号： F25B21/04 ,  B65D81/38 ,  F25B21/02 ,  F25B23/006 ,  F25B29/00 ,  F25D3/005 ,  F25D11/003 ,  F25D11/006

摘要： In some embodiments, a regulated thermal transfer device for a storage container includes: a phase change material unit, the phase change material unit including one or more walls surrounding a phase-change material region, and an aperture in the one or more walls; a heat pipe with a first end positioned within the phase change material unit, and a second end; a thermoelectric unit thermally connected to the second end of the heat pipe; a heat sink connected to the thermoelectric unit, and positioned to radiate heat away from the thermoelectric unit; and an electronic controller operably connected to the thermoelectric unit; wherein the regulated thermal transfer device is of a size and shape to be positioned so that the phase change material unit is within a storage region of a temperature-stabilized storage container, and the thermoelectric unit is positioned adjacent to an external surface of the temperature-stabilized storage container.

摘要翻译： 在一些实施例中，用于存储容器的调节热转移装置包括：相变材料单元，所述相变材料单元包括围绕相变材料区域的一个或多个壁和所述一个或多个壁中的孔; 具有位于所述相变材料单元内的第一端的热管，以及第二端; 与热管的第二端热连接的热电单元; 连接到热电单元的散热器，并且定位成将热量从热电单元辐射出来; 以及可操作地连接到所述热电单元的电子控制器; 其特征在于，所述调节型热转印装置的尺寸和形状要被定位成使得所述相变材料单元位于温度稳定的储存容器的存储区域内，并且所述热电单元位于所述温度稳定的储存容器的外表面附近， 稳定的储存容器。

公开(公告)号：US09237985B2

公开(公告)日：2016-01-19

申请号：US13945499

申请日：2013-07-18

申请人： Tokitae LLC

发明人： Philip A. Eckhoff ,  Muriel Y. Ishikawa ,  Orin Levine ,  Nels R. Peterson ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

IPC分类号： A61J1/06 ,  A61J1/14 ,  A61J1/20

CPC分类号： A61J1/1425 ,  A61J1/05 ,  A61J1/1406

摘要： Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.

摘要翻译： 描述了多室药物小瓶。 在一些实施方案中，多隔室药物瓶包括：多室药物储存区域，包括底壁，至少一个外壁和至少一个内壁，底壁，至少一个外壁和至少 一个内壁形成多个药物储存室，每个药物储存室包括与药物储存区域的底壁相对定位的孔口; 以及附接到所述药物储存区域的进入区域，所述进入区域包括多个导管，每个导管具有第一端和第二端，其中每个导管的第一端连接到药物储存室中的一个孔，并且 每个导管的第二端围绕与底壁相对定位的孔。

公开(公告)号：US09140476B2

公开(公告)日：2015-09-22

申请号：US13853245

申请日：2013-03-29

申请人： Tokitae LLC

发明人： Philip A. Eckhoff ,  William Gates ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Nathan P. Myhrvold ,  Nels R. Peterson ,  Clarence T. Tegreene ,  Charles Whitmer ,  Lowell L. Wood, Jr.

IPC分类号： F25D23/12 ,  F25D3/12 ,  B65D81/38 ,  B65D51/16

CPC分类号： F25D3/125 ,  B65D51/1644 ,  B65D81/3802 ,  B65D81/3811 ,  B65D81/3813 ,  B65D81/3823 ,  B65D81/3825 ,  B65D81/3834 ,  B65D81/3837 ,  B65D81/3888 ,  B65D81/3897 ,  B65D2203/10

摘要： In some embodiments, a substantially thermally sealed storage container includes an outer assembly and an evaporative cooling assembly integral to the container. In some embodiments, the outer assembly includes one or more sections of ultra efficient insulation material substantially defining at least one thermally-controlled storage region, and a single access conduit to the at least one thermally-controlled storage region. In some embodiments, the evaporative cooling assembly integral to the container includes: an evaporative cooling unit affixed to a surface of the at least one thermally-controlled storage region; a desiccant unit affixed to an external surface of the container; a vapor conduit, the vapor conduit including a first end and a second end, the first end attached to the evaporative cooling unit, the second end attached to the desiccant unit; and a vapor control unit attached to the vapor conduit.

摘要翻译： 在一些实施例中，基本上热密封的储存容器包括外部组件和与容器成一体的蒸发冷却组件。 在一些实施例中，外部组件包括基本上限定至少一个热控储存区域的一个或多个超高效绝缘材料部分和至少一个热控制存储区域的单个进入导管。 在一些实施例中，与容器成一体的蒸发冷却组件包括：固定在至少一个热控储存区域的表面上的蒸发冷却单元; 固定在容器的外表面上的干燥剂单元; 蒸汽导管，所述蒸汽管道包括第一端和第二端，所述第一端附接到所述蒸发冷却单元，所述第二端连接到所述干燥剂单元; 以及连接到蒸气导管的蒸气控制单元。

公开(公告)号：US11969393B2

公开(公告)日：2024-04-30

申请号：US14306443

申请日：2014-06-17

申请人： Tokitae LLC

发明人： John Boomgard ,  Fong-Li Chou ,  Philip A. Eckhoff ,  Fridrik Larusson ,  Shieng Liu ,  Krishnan Natarajan ,  Nels R. Peterson ,  Lowell L. Wood, Jr.

IPC分类号： A61J1/16 ,  A61J1/06 ,  A61J1/14 ,  B65D1/09 ,  B65D21/02

CPC分类号： A61J1/16 ,  A61J1/065 ,  A61J1/1406 ,  A61J1/1412 ,  B65D1/095 ,  B65D21/0201 ,  A61J2205/10 ,  A61J2205/30 ,  A61J2205/60

摘要： In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

公开(公告)号：US11083690B2

公开(公告)日：2021-08-10

申请号：US16528197

申请日：2019-07-31

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Tokitae LLC

发明人： Shiyi Zhang ,  Andrew Bellinger ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Dean Liang Glettig ,  Lowell L. Wood, Jr. ,  Philip A. Eckhoff

IPC分类号： A61K9/00 ,  C08G18/73 ,  C08G63/08 ,  C08G18/42 ,  A61K47/58 ,  A61K47/69 ,  A61K9/48 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  C08G83/00 ,  A61K47/32 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00

摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

公开(公告)号：US09649279B2

公开(公告)日：2017-05-16

申请号：US14572346

申请日：2014-12-16

申请人： Massachusetts Institute of Technology ,  Tokitae LLC

发明人： Ana Jaklenec ,  Xian Xu ,  Lowell L. Wood, Jr. ,  Philip A. Eckhoff ,  William Gates ,  Boris Nikolic ,  Robert S. Langer

IPC分类号： A23L1/304 ,  A23L1/00 ,  A61K47/00 ,  A61K9/50 ,  A61K31/519 ,  A61K47/26 ,  A61K47/36 ,  A61K31/295 ,  A61K33/30 ,  A61K31/07 ,  A61K31/714 ,  A61K31/375 ,  A61K31/593 ,  A61K33/18 ,  A23P10/30 ,  A23L27/00 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16

CPC分类号： A61K9/5026 ,  A23L27/72 ,  A23L27/74 ,  A23L33/10 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/4866 ,  A61K9/501 ,  A61K9/5073 ,  A61K31/07 ,  A61K31/23 ,  A61K31/295 ,  A61K31/375 ,  A61K31/519 ,  A61K31/593 ,  A61K31/714 ,  A61K33/18 ,  A61K33/26 ,  A61K33/30 ,  A61K45/06 ,  A61K47/26 ,  A61K47/36

摘要： Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.