公开(公告)号：US5100622A

公开(公告)日：1992-03-31

申请号：US492853

申请日：1990-03-13

申请人： Tomonori Mimura ,  Takehide Satou

发明人： Tomonori Mimura ,  Takehide Satou

IPC分类号： G01N33/49 ,  G01N21/31 ,  G01N33/52 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/00603 ,  G01N35/00594 ,  G01N35/0095 ,  G01N2035/0097 ,  G01N2035/0415 ,  G01N2035/0444 ,  G01N2201/127 ,  G01N35/00693 ,  G01N35/025 ,  G01N35/10 ,  Y10T436/115831 ,  Y10T436/12

摘要： An automatic analyzing apparatus and method transfers a sample to be examined to a sampling position, fractionally injects the sample into a reaction vessel by using sampling means, adds a reagent to the reaction vessel holding therein the sample fractionally injected to cause reaction, and measures absorbance of the reaction solution at predetermined time intervals using a photometer. A first check for checking whether an abnormality is present in the measurement result of each measurement item is made, followed by a second check for checking whether an abnormality is present on the basis of a change in the rate of absorbance measured after the reagent is added to the sample in the reaction vessel. Then, a third check computes correlation of measured absorbance data and checks whether an abnormality is present on the basis of the result of computation. Finally, a determination is made, with respect to the sample in accordance with an abnormal item when it is judged that an abnormality is present in the result of the first, second or third check, whether remeasurement is necessary, and for selecting, in case of remeasurement, either remeasurement under the same conditions or remeasurement with a reduced sample quantity as compared with that of the first measurement conditions. When remeasurement is determined, the sample is carried to the sampling position.

公开(公告)号：US4543238A

公开(公告)日：1985-09-24

申请号：US530630

申请日：1983-09-09

申请人： Tomonori Mimura ,  Hisayuki Sagusa ,  Takehide Satou ,  Katsuaki Takahashi

发明人： Tomonori Mimura ,  Hisayuki Sagusa ,  Takehide Satou ,  Katsuaki Takahashi

IPC分类号： G01N35/10 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N35/1004 ,  G01N2035/1025 ,  G01N2035/1086 ,  Y10T436/114998

摘要： A special cleaner is located between a sample cup at the sample absorbing position and a reaction case at the sample delivery position. This cleaner has a V-shaped recess, in which the cleaning liquid is filled in a pile. A pipetting tube is inserted into the sample cup, and a serum sample of the amount corresponding to a plurality of analysis items is absorbed and held by the pipetting tube. The pipetting tube hoisted upward is carried to the sample delivery position. In the process, the pipetting tube passes through cleaning liquid, so that the outer wall of the pipetting tube is cleaned within a short time, thus removing the excessive serum attached to the outer wall. The pipetting tube is lowered into the reaction case associated with the first analysis item to deliver a predetermined amount of serum sample thereinto. The pipetting tube is raised again and the train of reaction cases advances one step so that the tube is inserted into the next reaction case. After the delivery for a plurality of items, the inner and outer walls of the pipetting tube are cleaned.

摘要翻译： 特殊的清洁剂位于样品吸收位置的样品杯和样品传送位置的反应盒之间。 该清洁器具有V形凹部，其中清洁液体填充在一堆中。 将移液管插入到样品杯中，并且与多个分析物相对应的量的血清样品被移液管吸收并保持。 向上悬吊的移液管被运送到样品传送位置。 在此过程中，移液管通过清洗液，从而在短时间内清洗移液管的外壁，从而去除附着在外壁上的过量血清。 移液管下降到与第一分析项目相关联的反应室中，以将预定量的血清样品输送到其中。 移液管再次升高，反应箱体前进一步，使管插入下一个反应情况。 在输送多个物品之后，移液管的内壁和外壁被清洁。

公开(公告)号：US10203277B2

公开(公告)日：2019-02-12

申请号：US13641881

申请日：2011-04-05

申请人： Chihiro Manri ,  Satoshi Mitsuyama ,  Tomonori Mimura ,  Kumiko Kamihara

发明人： Chihiro Manri ,  Satoshi Mitsuyama ,  Tomonori Mimura ,  Kumiko Kamihara

IPC分类号： G01N21/27 ,  G01N35/00 ,  G01N21/78

摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.

公开(公告)号：US09664678B2

公开(公告)日：2017-05-30

申请号：US14238060

申请日：2012-09-03

申请人： Takeshi Yogi ,  Sakuichiro Adachi ,  Tomonori Mimura ,  Hajime Yamazaki

发明人： Takeshi Yogi ,  Sakuichiro Adachi ,  Tomonori Mimura ,  Hajime Yamazaki

IPC分类号： G01N21/51 ,  G01N33/543 ,  G01N21/82 ,  G01N35/02 ,  G01N21/47 ,  G01N35/04

CPC分类号： G01N33/54366 ,  G01N21/47 ,  G01N21/51 ,  G01N21/82 ,  G01N33/54313 ,  G01N35/025 ,  G01N2021/825 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2800/24

摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.

公开(公告)号：US09645160B2

公开(公告)日：2017-05-09

申请号：US14116177

申请日：2012-05-09

申请人： Sakuichiro Adachi ,  Tomonori Mimura ,  Hajime Yamazaki ,  Masaki Shiba

发明人： Sakuichiro Adachi ,  Tomonori Mimura ,  Hajime Yamazaki ,  Masaki Shiba

IPC分类号： G01N35/02 ,  G01N21/51 ,  G01N21/82 ,  G01N21/47 ,  G01N35/04

CPC分类号： G01N35/025 ,  G01N21/51 ,  G01N21/82 ,  G01N2021/4711 ,  G01N2035/0453

摘要： The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.

公开(公告)号：US09395298B2

公开(公告)日：2016-07-19

申请号：US13509661

申请日：2010-11-19

申请人： Akihisa Makino ,  Tomonori Mimura ,  Terumi Tamura ,  Sakuichiro Adachi

发明人： Akihisa Makino ,  Tomonori Mimura ,  Terumi Tamura ,  Sakuichiro Adachi

IPC分类号： G01N33/50 ,  G01N21/00 ,  G01N21/51 ,  G01N33/49 ,  G01N33/86 ,  G01N21/53 ,  G01N21/82 ,  G01N33/18

CPC分类号： G01N21/51 ,  G01N21/532 ,  G01N21/82 ,  G01N33/18 ,  G01N33/1826 ,  G01N33/4905 ,  G01N33/86 ,  G01N2021/4711 ,  G01N2021/825

摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.

摘要翻译： 一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。 分析仪具有反应容器。 提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。 判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。 计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

公开(公告)号：US20120141330A1

公开(公告)日：2012-06-07

申请号：US13382316

申请日：2010-07-05

申请人： Sakuichiro Adachi ,  Muneo Maeshima ,  Isao Yamazaki ,  Tomonori Mimura

发明人： Sakuichiro Adachi ,  Muneo Maeshima ,  Isao Yamazaki ,  Tomonori Mimura

IPC分类号： G01N21/00

CPC分类号： G01N21/51 ,  G01N15/0205 ,  G01N21/253 ,  G01N2015/0065 ,  G01N2035/00396 ,  G01N2035/0453

摘要： To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.

摘要翻译： 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。

公开(公告)号：US20120039748A1

公开(公告)日：2012-02-16

申请号：US13202337

申请日：2010-02-24

申请人： Tomonori Mimura ,  Akihisa Makino ,  Sakuichiro Adachi

发明人： Tomonori Mimura ,  Akihisa Makino ,  Sakuichiro Adachi

IPC分类号： G01N33/00

CPC分类号： G01N35/025 ,  G01N2035/0455

摘要： An automatic analysis apparatus capable of testing a plurality of items with high accuracy and at low cost without increasing the size of the apparatus is provided. An automatic analysis apparatus 1 having test mechanisms for a plurality of items including a photometric mechanism 70 and flow analysis mechanisms 40a and 40b is provided with a common disk (disk for reaction and pretreatment) 20. In the common disk 20, fixed containers 21 fixed to the common disk 20 and detachably-provided disposable containers 22 are disposed. Therefore, while achieving the downsizing of the apparatus, the containers to be used can be selected in accordance with the test items in such a manner that the fixed containers 21 are used as high-accuracy containers to be cleaned and reused and the disposable containers 22 are used as low-cost disposable containers.

摘要翻译： 提供了一种能够在不增加设备尺寸的情况下以高精度和低成本测试多个项目的自动分析装置。 具有包括测光机构70和流量分析机构40a，40b的多个项目的测试机构的自动分析装置1设置有公共盘（反应和预处理盘）20。在普通盘20中，固定容器21固定 配置在普通盘20上，可拆卸地设置一次性容器22。 因此，在实现装置的小型化的同时，可以根据试验项目来选择要使用的容器，使得固定容器21用作待清洁和重复使用的高精度容器，并且一次性容器22 被用作低成本的一次性容器。

公开(公告)号：US20110125415A1

公开(公告)日：2011-05-26

申请号：US12995219

申请日：2009-05-28

申请人： Satoshi Mitsuyama ,  Yuki Fukuyama ,  Hidekatsu Takada ,  Hideyuki Ban ,  Tomonori Mimura

发明人： Satoshi Mitsuyama ,  Yuki Fukuyama ,  Hidekatsu Takada ,  Hideyuki Ban ,  Tomonori Mimura

IPC分类号： G06F19/00 ,  G01N35/00 ,  G01N21/00

CPC分类号： G01N21/77 ,  G01N21/272 ,  G01N21/78 ,  G01N35/00603 ,  G01N2035/0097

摘要： In the event of a suspected abnormality in the device, sample or reagent, a laboratory technician had to examine the abnormal reaction process data item by item, and infer the cause of the abnormality, which took effort and time in some cases. Abnormality judgment is assisted using: indicator computation means that computes an indicator indicating a feature parameter of a given waveform by applying a pre-defined evaluation formula to time series data of photometric values; relative indicator computation means that computes a value indicating a relationship of the indicator of target data to the indicator computed in the past; and indicator display means that simultaneously displays a value computed by the indicator computation means and the value computed by the relative indicator computation means. According to the present method, which is a method for assisting judgment of abnormality wherein a feature parameter of a given absorbance change is computed, it can be made easier to find certain abnormalities, and it becomes possible to attain more efficient device maintenance and improved device reliability without the addition of any new parts.

摘要翻译： 如果装置，样品或试剂中有疑似异常，实验室技术人员必须逐项检查异常反应过程数据，并推断异常的原因，在某些情况下花费时间和精力。 协助使用以下方式辅助异常判断：指标计算装置，通过对光度值的时间序列数据应用预定义的评估公式来计算指示给定波形的特征参数的指标; 相对指标计算是指计算出目标数据指标与过去计算出的指标的关系的值; 指示符显示装置，同时显示由指标计算装置计算的值和由相关指标计算装置计算的值。 根据本方法，其是计算给定吸光度变化的特征参数的异常判断方法，可以更容易地发现某些异常，并且可以实现更有效的装置维护和改进装置 可靠性无需添加任何新零件。

公开(公告)号：US20100233027A1

公开(公告)日：2010-09-16

申请号：US12785835

申请日：2010-05-24

申请人： Hajime KATOU ,  Ryo Miyake ,  Hiroyasu Uchida ,  Katsuhiro Kambara ,  Takenori Okusa ,  Shigenori Watari ,  Yoichiro Suzuki ,  Tomonori Mimura ,  Miki Taki ,  Akira Inagaki

发明人： Hajime KATOU ,  Ryo Miyake ,  Hiroyasu Uchida ,  Katsuhiro Kambara ,  Takenori Okusa ,  Shigenori Watari ,  Yoichiro Suzuki ,  Tomonori Mimura ,  Miki Taki ,  Akira Inagaki

IPC分类号： G01N29/00

CPC分类号： G01N35/1002 ,  B01F11/0283 ,  B01F2215/0037 ,  G01N35/025 ,  G01N2035/00554 ,  Y10S707/962 ,  Y10S707/99933 ,  Y10S707/99942 ,  Y10S707/99943 ,  Y10S707/99956

摘要： A chemical analysis apparatus comprising reaction containers containing therein a substance to be analyzed; an agitating mechanism spaced from the substance to be analyzed and agitating said substance to be analyzed with a liquid in said reaction container; and, a measuring portion for measuring physical properties of the substance to be analyzed, said agitating mechanism having a sound supply portion supplying sound waves to the substance to be analyzed, wherein said sound supply portion comprises a mechanism changing, in time, intensity of ultrasonic waves to be irradiated so as to apply pulsation to a swirl flow in the reaction container.

摘要翻译： 一种化学分析装置，包括含有待分析物质的反应容器; 与待分析物质间隔开的搅拌机构，并在所述反应容器中用液体搅拌待分析物质; 以及用于测量被分析物质的物理性质的测量部分，所述搅拌机构具有向待分析物质供应声波的声音供给部分，其中所述声音供应部分包括时间上改变超声波强度的机构 要被照射的波浪以便对反应容器中的涡流施加脉动。