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12 条记录 (耗时 0.027 秒)

    AGENT FOR ENHANCING THE EFFECT OF SKIN-WHITENING INGREDIENTS AND USES THEREOF
    5.
    发明申请
    AGENT FOR ENHANCING THE EFFECT OF SKIN-WHITENING INGREDIENTS AND USES THEREOF 审中-公开
    用于增强皮肤白化成分及其用途的用途的药剂

    公开(公告)号：US20130129651A1

    公开(公告)日：2013-05-23

    申请号：US13813760

    申请日：2011-07-28

    申请人： Masaki Miyake ,  Osamu Sano ,  Kanso Iwaki ,  Takanori Okura ,  Shigeharu Fukuda

    发明人： Masaki Miyake ,  Osamu Sano ,  Kanso Iwaki ,  Takanori Okura ,  Shigeharu Fukuda

    IPC分类号： C07H19/20 ,  C07H19/16 ,  A61Q19/02 ,  C07D473/18

    CPC分类号： A61K8/606 ,  A61K8/4953 ,  A61Q19/02 ,  C07D473/18 ,  C07H19/16 ,  C07H19/20

    摘要： The present invention has objects to provide an agent for enhancing the effect of skin-whitening ingredients which enhances the skin-whitening action of skin-whitening ingredients and has an improved safeness, and to provide a skin-whitening agent, which contains the above agent and a skin-whitening ingredient(s) and has an improved and enhanced skin-whitening action. The present invention solves the above objects by providing an agent for enhancing the effect of skin-whitening ingredients, which contains one or more members selected from the group consisting of guanine and derivatives thereof as an effective ingredient(s); and a skin-whitening agent which contains the above agent along with a skin-whitening ingredient(s) particularly, members derivatives thereof and/or equol including derivatives thereof.

    摘要翻译： 本发明的目的是提供增强美白成分的效果的药剂，其增强皮肤美白成分的皮肤美白作用，并且具有改善的安全性，并且提供含有上述药剂的皮肤增白剂 和一种皮肤美白成分，并具有改进和增强的皮肤美白作用。 本发明通过提供含有一种或多种选自鸟嘌呤及其衍生物作为有效成分的成分的皮肤美白成分的效果增强剂来解决上述目的。 以及皮肤增白剂，其含有上述药剂以及皮肤美白成分，特别是其成分衍生物和/或雌马酚，包括其衍生物。

    AGENT FOR ENHANCING THE PRODUCTION OF CYTOKINES AND/OR CHEMOKINES
    6.
    发明申请
    AGENT FOR ENHANCING THE PRODUCTION OF CYTOKINES AND/OR CHEMOKINES 审中-公开
    用于增强细胞因子和/或细胞因子生产的代理

    公开(公告)号：US20090148943A1

    公开(公告)日：2009-06-11

    申请号：US12265348

    申请日：2008-11-05

    申请人： Makoto TAKEUCHI ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

    发明人： Makoto TAKEUCHI ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

    IPC分类号： C12N5/06

    CPC分类号： C07K14/4705 ,  A61K38/00

    摘要： The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.

    摘要翻译： 本发明的目的是提供有效增强哺乳动物中细胞因子和/或趋化因子的产生的方法。 通过提供用于增强细胞因子和/或趋化因子的产生的试剂来解决该问题，所述试剂包含作为有效成分的具有SEQ ID NO：1至3的任一氨基酸序列的多肽; 具有SEQ ID NO：1至3的任何一个氨基酸序列的多肽，其中一个或多个氨基酸被缺失或被其它氨基酸和/或一个或多个氨基酸所取代，而没有 基本上丧失了多肽的生物活性。

    Agent for enhancing the production of cytokines and/or chemokines
    7.
    发明申请
    Agent for enhancing the production of cytokines and/or chemokines 审中-公开
    用于增强细胞因子和/或趋化因子产生的药剂

    公开(公告)号：US20070110711A1

    公开(公告)日：2007-05-17

    申请号：US11583148

    申请日：2006-10-19

    申请人： Makoto Takeuchi ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

    发明人： Makoto Takeuchi ,  Takanori Okura ,  Tomoki Tatefuji ,  Tetsuya Mori ,  Chikako Arai ,  Tsunetaka Ohta ,  Masashi Kurimoto

    IPC分类号： A61K38/19 ,  C07K14/52

    CPC分类号： C07K14/4705 ,  A61K38/00

    摘要： The present invention has an object to provide a means to effectively enhance the production of cytokines and/or chemokines in mammals. The object is solved by providing an agent for enhancing the production of cytokines and/or chemokines, which comprises, as an effective ingredient, a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3; a polypeptide having any one of the amino acid sequences of SEQ ID NOs:1 to 3, where one or more amino acids thereof are deleted or replaced with other amino acid(s) and/or one or more amino acids are added thereunto, without substantially losing the biological activity of the polypeptide.

    摘要翻译： 本发明的目的是提供有效增强哺乳动物中细胞因子和/或趋化因子的产生的方法。 通过提供用于增强细胞因子和/或趋化因子的产生的试剂来解决该问题，所述试剂包含作为有效成分的具有SEQ ID NO：1至3的任一氨基酸序列的多肽; 具有SEQ ID NO：1至3的任何一个氨基酸序列的多肽，其中一个或多个氨基酸被缺失或被其它氨基酸和/或一个或多个氨基酸加入，而没有 基本上丧失了多肽的生物活性。

    Method of treatment using anti-IL-18 antibody
    8.
    发明申请
    Method of treatment using anti-IL-18 antibody 审中-公开
    使用抗IL-18抗体的治疗方法

    公开(公告)号：US20060110389A1

    公开(公告)日：2006-05-25

    申请号：US11335474

    申请日：2006-01-20

    申请人： Yoshihiro Nishida ,  Takanori Okura ,  Tadao Tanimoto ,  Masashi Kurimoto

    发明人： Yoshihiro Nishida ,  Takanori Okura ,  Tadao Tanimoto ,  Masashi Kurimoto

    IPC分类号： A61K39/395 ,  C07K16/24

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/76

    摘要： Disclosed are artificially produced peptide capable of neutralizing the biological activities of IL-18, which comprises a part or the whole of the variable regions in anti interleukin 18 antibody, including single chain variable region fragments and humanized antibodies, a process of producing the peptide, and uses thereof. The peptide is useful as pharmaceutical to treat and prevent diseases such as autoimmune diseases and inflammatory diseases, where the biological activities of interleukin-18 are involved.

    摘要翻译： 公开了能够中和IL-18的生物活性的人造产生的肽，其包含抗白细胞介素18抗体中的部分或全部可变区，包括单链可变区片段和人源化抗体，生产肽的方法， 及其用途。 该肽可用作治疗和预防涉及白细胞介素-18的生物学活性的疾病如自身免疫性疾病和炎性疾病的药物。

    Genomic DNA encoding a polypeptide capable of inducing the production of interferon-&ggr;
    9.
    发明授权
    Genomic DNA encoding a polypeptide capable of inducing the production of interferon-&ggr; 失效
    编码能够诱导产生干扰素-γ的多肽的基因组DNA

    公开(公告)号：US06790442B1

    公开(公告)日：2004-09-14

    申请号：US09479862

    申请日：2000-01-10

    申请人： Takanori Okura ,  Kakuji Torigoe ,  Masashi Kurimoto

    发明人： Takanori Okura ,  Kakuji Torigoe ,  Masashi Kurimoto

    IPC分类号： A01N6300

    CPC分类号： C07K14/54

    摘要： Disclosed is a genomic DNA encoding a polypeptide capable of inducing the production of interferon-&ggr; by immunocompetent cells. The genomic DNA efficiently expresses the polypeptide with high biological activities of such as inducing the production of interferon-&ggr; by immunocompetent cells, enhancing killer cells' cytotoxicity and inducing killer cells' formation, when introduced into mammalian host cells. The high biological activities of the polypeptide facilitate its uses to treat and/or prevent malignant tumors, viral diseases, bacterial infectious diseases and immune diseases without serious side effects when administered to humans.

    摘要翻译： 公开了编码能够通过免疫活性细胞诱导干扰素-γ产生的多肽的基因组DNA。 基因组DNA有效地表达具有高生物活性的多肽，例如当被引入到哺乳动物宿主细胞中时，通过免疫活性细胞诱导干扰素-γ的产生，增强杀伤细胞的细胞毒性和诱导杀伤细胞的形成。 多肽的高生物活性有助于其用于治疗和/或预防恶性肿瘤，病毒性疾病，细菌感染性疾病和免疫疾病，而当给予人时没有严重的副作用。

    Interleukin-18 (IL-18) receptor polypeptides and their uses
    10.
    发明授权
    Interleukin-18 (IL-18) receptor polypeptides and their uses 失效
    白细胞介素-18（IL-18）受体多肽及其用途

    公开(公告)号：US6087116A

    公开(公告)日：2000-07-11

    申请号：US996338

    申请日：1997-12-22

    申请人： Kakuji Torigoe ,  Takanori Okura ,  Masashi Kurimoto

    发明人： Kakuji Torigoe ,  Takanori Okura ,  Masashi Kurimoto

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C12N5/08 ,  C12N15/12 ,  A61K38/17 ,  G01N33/53

    CPC分类号： C07K14/7155 ,  A61K38/00

    摘要： The receptor for interleukin-18 (IL-18) is described. The invention provides recombinant receptor polypeptides, including soluble receptors and fusion proteins, which specifically bind to IL-18 and inhibit its activity. The polypeptides are thus useful as pharmaceutical agents to treat autoimmune and allergic diseases. They are also useful as affinity reagents to purify IL-18, in assays to detect the ligand, and in screening assays to identify IL-18 agonists or antagonists.

    摘要翻译： 描述了白细胞介素-18（IL-18）的受体。 本发明提供了特异性结合IL-18并抑制其活性的重组受体多肽，包括可溶性受体和融合蛋白。 因此，多肽可用作治疗自身免疫性和过敏性疾病的药物。 它们也可用作纯化IL-18的亲和试剂，用于检测配体的测定中，以及用于鉴定IL-18激动剂或拮抗剂的筛选试验。