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公开(公告)号：US07053367B2
公开(公告)日：2006-05-30
申请号：US10494335
申请日：2001-11-07
IPC分类号： H01J49/00
CPC分类号： H01J49/067 , H01J49/044
摘要： In a mass spectrometer utilizing an atmospheric pressure ion source, the amount of un-vaporized droplets that reach a mass spectrometric section is reduced. A mass spectrometer comprises: an ionization section for ionizing a sample at substantially atmospheric pressure; a first and a second intermediate pressure section in which the pressure is maintained lower than the pressure in said ionization section; a high vacuum section in which the pressure is maintained lower than the pressure in said intermediate pressure section and in which a mass spectrometric means for subjecting ions to mass spectrometry is disposed; a first pore electrode disposed between said ionization section and said first intermediate pressure section; an intermediate pore electrode disposed between said first intermediate pressure section and said second intermediate pressure section; and a second pore electrode disposed between said second intermediate pressure section and said high vacuum section. A first converging electrode is provided in the first intermediate pressure section, the first converging electrode having an opening towards the first pore electrode and another opening towards the intermediate pore electrode. The opening towards the first pore electrode has a larger diameter than the opening towards the intermediate pore electrode, such that the first converging electrode has a tapered shape.
摘要翻译： 在使用大气压离子源的质谱仪中，达到质谱分析的未汽化液滴的量减少。 质谱仪包括：用于在基本上大气压下电离样品的电离部分; 第一和第二中间压力段，其中所述压力保持低于所述电离部分中的压力; 其中压力保持低于所述中压部分中的压力并且其中设置用于使离子进行质谱分析的质谱装置的高真空部分; 设置在所述电离部和所述第一中间压部之间的第一孔电极; 设置在所述第一中间压力部分和所述第二中间压力部分之间的中间孔电极; 以及设置在所述第二中间压力部分和所述高真空部分之间的第二孔电极。 第一会聚电极设置在第一中间压力部分中，第一会聚电极具有朝向第一孔电极的开口和朝向中间孔电极的另一开口。 朝向第一孔电极的开口具有比朝向中间孔电极的开口更大的直径，使得第一会聚电极具有锥形形状。
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公开(公告)号：US06977373B2
公开(公告)日：2005-12-20
申请号：US10846529
申请日：2004-05-17
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译： 一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地 在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。
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公开(公告)号：US06759652B2
公开(公告)日：2004-07-06
申请号：US10252699
申请日：2002-09-24
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Masaru Tomioka
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/4255
摘要： An ion-trap mass analyzing apparatus having means for generating ion-capture electric fields asymmetrical with respect to a reference plane containing a central point of a ring electrode and perpendicular to a central axis of the ring electrode in the inside of an ion trap to resonantly amplify ions rapidly to emit the ions from the ion trap in a short time to thereby permit high-sensitive high-accurate mass analysis stably regardless of the structural stability of ions as a subject of analysis.
摘要翻译： 一种离子阱质量分析装置，具有用于产生相对于包含环形电极的中心点并垂直于离子阱内部的环形电极的中心轴的参考平面不对称的离子捕获电场的装置，以共振地 在短时间内快速放大离子以从离子阱发射离子，从而允许高灵敏度的高精确质量分析，而不管作为分析对象的离子的结构稳定性如何。
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公开(公告)号：US07544930B2
公开(公告)日：2009-06-09
申请号：US11624248
申请日：2007-01-18
IPC分类号： H01J49/00
CPC分类号： H01J49/02 , H01J49/004
摘要： The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of m/z regions are set up for carrying out the mass analysis with the all ions included therein being dissociated collectively for each m/z region so as to obtain measurement MS2 data. By comparing the measurement MS2 data with reference MS2 data stored in a reference data base, a difference thereof is detected. For the m/z region with a differential component detected, the mass analysis is carried out collectively without dissociation for the all ions included therein so as to obtain measurement MS1 data. By comparing the measurement MS1 data with the reference MS1 data, a difference thereof is detected. From the difference thereof, a parent ion considered to be the differential component factor is presumed for carrying out the mass analysis with the same being dissociated.
摘要翻译： 本发明提供一种能够通过串联型质量分析以高效率进行差示分析的串联式质量分析系统。 建立预定数量的m / z区域以进行质量分析，其中包含的全部离子为每个m / z区域共同解离，以获得测量MS2数据。 通过将测量MS2数据与参考数据库中存储的参考MS2数据进行比较，检测其差异。 对于检测到差分成分的m / z区域，对于其中包含的所有离子，不分离地进行质量分析，以获得测量MS1数据。 通过将测量MS1数据与参考MS1数据进行比较，检测其差异。 从它们的差异来看，推测认为是差分成分因子的母离子用于进行相同解离的质量分析。
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公开(公告)号：US20060043281A1
公开(公告)日：2006-03-02
申请号：US11210965
申请日：2005-08-25
CPC分类号： H01J49/04 , G01N30/24 , G01N30/467 , G01N30/7206 , G01N30/724 , G01N30/8658 , H01J49/0027
摘要： In a method for mass spectrometry, a plurality of juxtaposed chromatography apparatus connected to a mass spectrometer start eluting at a predetermined time difference and the following mass spectrometer conducts mass spectrometry. A chromatogram in a preceding chromatography apparatus is analyzed on real time base and results of the analysis are used on real time base to change an elusion condition of a succeeding chromatography apparatus. A mass spectrometric system suitable for carrying out the method is also provided.
摘要翻译： 在质谱法中，与质谱仪连接的多个并置色谱装置开始以预定的时间差洗脱，随后的质谱仪进行质谱分析。 在实时基础上分析先前色谱装置中的色谱图，并将实时分析结果用于改变后续色谱装置的脱色条件。 还提供了适用于实施该方法的质谱系统。
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公开(公告)号：US07932486B2
公开(公告)日：2011-04-26
申请号：US12330374
申请日：2008-12-08
申请人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
发明人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
IPC分类号： H01J49/26
CPC分类号： G01N33/6851 , G01N33/6848 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
摘要翻译： 在通过串联质谱法对蛋白质或肽进行结构分析期间，作为串联质谱目标，可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的，从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和来自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式，可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程，并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱（MSn）的MSn的每个步骤中被有效地利用，使得用于确定下一个分析内容的流程和为母体离子的选择 例如，MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此，用户关注的目标可以进行串联质谱，无需浪费测量。
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公开(公告)号：US20050139761A1
公开(公告)日：2005-06-30
申请号：US10993495
申请日：2004-11-22
申请人： Kiyomi Yoshinari , Kinya Kobayashi , Lee Chahn
发明人： Kiyomi Yoshinari , Kinya Kobayashi , Lee Chahn
CPC分类号： H01J49/0036 , G06F19/16 , G06F19/703
摘要： A main object is to cope with an unknown structure substance thereby to identify the structure of a parent ion highly precisely and to derive a supposed structure. A method for analyzing mass spectrometric data is disclosed, which: acquires mass spectrometric data on an ionized sample and dissociated ions dissociated from the sample as a parent ion; derives dissociated ion candidates by analyzing the molecular orbits on the candidates of the structures of the parent ion; and displays the analytical results of the parent ion candidates and the dissociated ion candidates and compares the data of the dissociated ion candidates and the data of dissociated ions actually measured, to evaluate the structures of the parent ion candidates.
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公开(公告)号：US06852972B2
公开(公告)日：2005-02-08
申请号：US10446667
申请日：2003-05-29
CPC分类号： H01J49/424 , H01J49/004 , H01J49/401 , H01J49/427
摘要： Heavy ions are ejected earlier than light ions sequentially at almost zero energy and they are accelerated at a fixed voltage so as to be guided to a pusher of a TOF spectrometer. After ions are ejected in a procedure of giving an electric field gradient to an ion trap and linearly decreasing its RF voltage, a condition of spatially focusing ions having all mass numbers of a single point on the pusher is found. The focused ions are vertically accelerated using the pusher to perform the TOF mass spectrometry.
摘要翻译： 重离子比轻离子顺序地以几乎零的能量排出，并且它们以固定电压被加速，以被引导到TOF光谱仪的推动器。 在向离子阱提供电场梯度并线性地降低其RF电压的过程中排出离子之后，发现在推动器上具有单个质点数的空间聚焦的条件。 使用推动器垂直加速聚焦的离子进行TOF质谱。
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公开(公告)号：US06683303B2
公开(公告)日：2004-01-27
申请号：US10087743
申请日：2002-03-05
申请人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Tadao Mimura , Shinji Nagai
IPC分类号： H01J4942
CPC分类号： H01J49/424 , H01J49/0063
摘要： An ion trap mass spectrometer and spectrometry capable of dissociating ions to be dissociated efficiently regardless of ionic species without useless time and performing high-sensitive MS/MS spectrometry, lengthens a period for applying a CID voltage in accordance with a mass number or characteristics of ions to be dissociated in proportion to a mass-to-charge ratio of ions to be dissociated to thereby optimize the application period of the supplementary AC voltage applied in superposition manner in order to dissociate specific ionic species, so that ions to be dissociated are dissociated efficiently and high-sensitive analysis of dissociated ions can be attained without useless time.
摘要翻译： 离子阱质谱仪和光谱测定能够离子离子有效解离而无需离子物质无需时间，并进行高灵敏度的MS / MS光谱测定，延长了根据离子的质量数或特征施加CID电压的时间 要与待离解的离子的质荷比成比例地离解，从而优化以叠加方式施加的辅助AC电压的施加周期，以便解离特定的离子物质，使得要解离的离子有效解离 并且可以在没有无用的时间的情况下获得离解离子的高灵敏度分析。
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公开(公告)号：US06633033B2
公开(公告)日：2003-10-14
申请号：US09730935
申请日：2000-12-06
IPC分类号： H01J4942
CPC分类号： H01J49/4285 , H01J49/424
摘要： Depending on the RF driving voltage amplitude value and the frequency of each frequency component of wideband auxiliary AC voltages, the wideband auxiliary AC voltage comprising plural different frequency components is optimized so that undesired ions having mass-to-charge ratios within the required range will be resonantly ejected from the ion trap electrodes.
摘要翻译： 根据RF驱动电压幅度值和宽带辅助AC电压的每个频率分量的频率，包括多个不同频率分量的宽带辅助AC电压被优化，使得具有所需范围内的质荷比的不期望的离子将是 从离子阱电极共振地喷出
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