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公开(公告)号:US06787534B2
公开(公告)日:2004-09-07
申请号:US10149253
申请日:2002-06-10
申请人: Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Naoko Tsukahara , Takashi Owa
发明人: Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Naoko Tsukahara , Takashi Owa
IPC分类号: A61K3133
CPC分类号: C07D215/38 , C07D215/48 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D311/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D411/12 , C07D417/12 , C07D471/04
摘要: The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, A is hydrogen atom, a halogen atom, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, or cyano group; B is an optionally substituted aryl group or monocyclic heteroaryl group, or: (wherein, the ring Q is an aromatic ring which may have nitrogen atom; and the ring M is a ring sharing a double bond with the ring Q, which ring may have a heteroatom; and the rings Q and M may share nitrogen atom); K is a single bond; T, W, X and Y are the same as or different from each other and each is ═C(D)— (wherein, D is hydrogen or a halogen atom) or nitrogen atom; U and V are the same as or different from each other and each is ═C(D)—, nitrogen atom, —CH2—, oxygen atom or —CO—; Z is a single bond or —CO—NH—; and R1 is hydrogen atom, etc.
摘要翻译: 本发明提供了含磺酰胺或磺酰脲的杂环化合物。 具体地说,它提供由式(I)表示的杂环化合物,其药理学上可接受的盐或它们的水合物。在该式中,A是氢原子,卤素原子,可以是C 1 -C 4烷基或烷氧基的 被卤素原子或氰基取代; B是任选取代的芳基或单环杂芳基,或者:(其中,环Q是可以具有氮原子的芳环;环M是与环Q共享双键的环,该环可以具有 杂原子;并且环Q和M可以共享氮原子); K是单键; T,W,X和Y彼此相同或不同,并且各自为= C(D) - (其中,D为氢或卤素原子)或氮原子; U和V彼此相同或不同,并且各自为= C(D) - ,氮原子,-CH 2 - ,氧原子或-CO-; Z是单键或-CO-NH-; R1为氢原子等
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公开(公告)号:US5846969A
公开(公告)日:1998-12-08
申请号:US873033
申请日:1997-06-11
申请人: Hiroshi Yoshino , Norihiro Ueda , Jun Niijima , Toru Haneda , Yoshihiko Kotake , Kentaro Yoshimatsu , Tatsuo Watanabe , Takeshi Nagasu , Naoko Tsukahara , Nozomu Koyanagi , Kyosuke Kitoh
发明人: Hiroshi Yoshino , Norihiro Ueda , Jun Niijima , Toru Haneda , Yoshihiko Kotake , Kentaro Yoshimatsu , Tatsuo Watanabe , Takeshi Nagasu , Naoko Tsukahara , Nozomu Koyanagi , Kyosuke Kitoh
IPC分类号: C07C211/55 , C07C229/58 , C07C311/29 , C07D209/88 , C07D219/04 , C07D219/06 , C07D219/08 , C07D221/12 , C07D223/22 , C07D243/38 , C07D265/38 , C07D267/18 , C07D267/20 , C07D279/20 , C07D281/14 , C07D413/12 , C07D498/04 , C07D513/04 , C07F7/18 , A61K31/55 , A61K31/505 , C07D487/00 , C07D471/00
CPC分类号: C07D219/04 , C07C211/55 , C07C229/58 , C07C311/29 , C07D209/88 , C07D219/06 , C07D219/08 , C07D221/12 , C07D223/22 , C07D243/38 , C07D265/38 , C07D267/18 , C07D267/20 , C07D279/20 , C07D281/14 , C07D413/12 , C07D513/04 , C07F7/1856
摘要: A sulfonamide derivative or a sulfonic ester derivative represented by the following general formula (I): ##STR1## {G represents an aromatic 5- or 6-membered ring; L represents O or --N(R.sup.1)-- (R.sup.1 represents hydrogen or lower alkyl); and M represents ##STR2## rings A and B represent each an unsaturated 5- or 6-membered ring; Y represents O, S(O).sub.n, C(R.sup.3)(R.sup.4), C(O), N(R.sup.5), CH(R.sup.6)CH(R.sup.7), C(R.sup.8).dbd.C(R.sup.9), N(R.sup.10)C(O), N.dbd.C(R.sup.11), OCH(R.sup.12), S(O).sub.n CH(R.sup.13) or N(R.sup.14)CH(R.sup.15).
摘要翻译: (I)表示的磺酰胺衍生物或磺酸酯衍生物:(I){G表示芳香族5-或6-元环; L表示O或-N(R 1) - (R 1表示氢或低级烷基); (D)环A和B各自表示不饱和的5-或6-元环; Y表示O,S(O)n,C(R3)(R4),C(O),N(R5),CH(R6)CH(R7),C(R8)= C(R9) )C(O),N = C(R 11),OCH(R 12),S(O)n CH(R 13)或N(R 14)CH(R 15)。
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公开(公告)号:US5854274A
公开(公告)日:1998-12-29
申请号:US760738
申请日:1996-12-05
申请人: Hiroshi Yoshino , Norihiro Ueda , Jun Niijima , Toru Haneda , Yoshihiko Kotake , Kentaro Yoshimatsu , Tatsuo Watanabe , Takeshi Nagasu , Naoko Tsukahara , Nozomu Koyanagi , Kyosuke Kitoh
发明人: Hiroshi Yoshino , Norihiro Ueda , Jun Niijima , Toru Haneda , Yoshihiko Kotake , Kentaro Yoshimatsu , Tatsuo Watanabe , Takeshi Nagasu , Naoko Tsukahara , Nozomu Koyanagi , Kyosuke Kitoh
IPC分类号: C07C211/55 , C07C229/58 , C07C311/29 , C07D209/88 , C07D219/04 , C07D219/06 , C07D219/08 , C07D221/12 , C07D223/22 , C07D243/38 , C07D265/38 , C07D267/18 , C07D267/20 , C07D279/20 , C07D281/14 , C07D413/12 , C07D498/04 , C07D513/04 , C07F7/18 , A61K31/44 , A61K31/40 , C07D221/06 , C07D209/82
CPC分类号: C07D219/04 , C07C211/55 , C07C229/58 , C07C311/29 , C07D209/88 , C07D219/06 , C07D219/08 , C07D221/12 , C07D223/22 , C07D243/38 , C07D265/38 , C07D267/18 , C07D267/20 , C07D279/20 , C07D281/14 , C07D413/12 , C07D513/04 , C07F7/1856
摘要: Novel tricyclic heterocyclic sulfonamide derivatives and sulfonic ester derivatives which have excellent antitumor activity and are represented by the following general formula (I) and processes for producing the same are provided. The present sulfonamide derivatives or a sulfonic ester derivatives are represented by the following general formula (I): ##STR1## wherein G represents an aromatic 5- or 6-membered ring; L represents 0 or --N(R.sup.1)-- and --R.sup.1 represents hydrogen or lower alkyl; and M represents a tricyclic structure selected from among the following; ##STR2## rings A and B each represent an unsaturated 5- or 5 -membered ring; X represents N(R.sup.2) wherein R.sup.2 represents hydrogen or lower alkyl, or NHCO; Y represents 0, S(O).sub.n, C(R.sup.3) (R.sup.4), C(O), N(R.sup.5), CH(R.sup.6)CH(R.sup.7), C(R.sup.8).dbd.C(R.sup.9), N(R.sup.10) C(O), N.dbd.CR.sup.11), OCH(R.sup.12), S(O).sub.n CH(R.sup.13) or N(R.sup.14)CH(R.sup.15); Z represents nitrogen or C(R.sup.16); and n represents 0, 1 or 2, R.sup.3 to R.sub.13, R.sup.15 and R.sup.16 each represent hydrogen or lower alkyl, and R.sup.14 represents hydrogen, lower alkyl or lower acyl.
摘要翻译: 提供具有优异抗肿瘤活性并由以下通式(I)表示的新型三环杂环磺酰胺衍生物和磺酸酯衍生物及其制备方法。 本发明的磺酰胺衍生物或磺酸酯衍生物由以下通式(I)表示:其中G表示芳族5-或6-元环; L表示0或-N(R1) - ,-R1表示氢或低级烷基; M表示选自以下的三环结构: (a)
(b) (c) (d) (e) (f)环A和B各自表示不饱和5-或5- 环; X表示N(R2),其中R2表示氢或低级烷基或NHCO; Y表示0,S(O)n,C(R3)(R4),C(O),N(R5),CH(R6)CH(R7),C(R8)= C(R9) )C(O),N = CR 11),OCH(R 12),S(O)n CH(R 13)或N(R 14)CH(R 15)。 Z表示氮或C(R16); 并且n表示0,1或2,R 3至R 13,R 15和R 16各自表示氢或低级烷基,R 14表示氢,低级烷基或低级酰基。 -
公开(公告)号:US5834462A
公开(公告)日:1998-11-10
申请号:US397254
申请日:1995-03-23
申请人: Hiroshi Yoshino , Norihiro Ueda , Jun Niijima , Toru Haneda , Yoshihiko Kotake , Kentaro Yoshimatsu , Tatsuo Watanabe , Takeshi Nagasu , Naoko Tsukahara , Nozomu Koyanagi , Kyosuke Kitoh
发明人: Hiroshi Yoshino , Norihiro Ueda , Jun Niijima , Toru Haneda , Yoshihiko Kotake , Kentaro Yoshimatsu , Tatsuo Watanabe , Takeshi Nagasu , Naoko Tsukahara , Nozomu Koyanagi , Kyosuke Kitoh
IPC分类号: C07C211/55 , C07C229/58 , C07C311/29 , C07D209/88 , C07D219/04 , C07D219/06 , C07D219/08 , C07D221/12 , C07D223/22 , C07D243/38 , C07D265/38 , C07D267/18 , C07D267/20 , C07D279/20 , C07D281/14 , C07D413/12 , C07D498/04 , C07D513/04 , C07F7/18 , A61K31/40 , A61K31/47
CPC分类号: C07D219/04 , C07C211/55 , C07C229/58 , C07C311/29 , C07D209/88 , C07D219/06 , C07D219/08 , C07D221/12 , C07D223/22 , C07D243/38 , C07D265/38 , C07D267/18 , C07D267/20 , C07D279/20 , C07D281/14 , C07D413/12 , C07D513/04 , C07F7/1856
摘要: Novel tricyclic heterocyclic sulfonamide derivatives and sulfonic ester derivatives which have each an antitumor action and are represented by the following general formula (I) and processes for producing the same are provided. These compounds have each an excellent antitumor activity. A sulfonamide derivative or a sulfonic ester derivative represented by the following general formula (I): ##STR1## {G represents an aromatic 5- or 6-membered ring; L represents 0 or --N(R.sup.1)-- (R.sup.1 represents hydrogen or lower alky); and M represents a tricyclic structure selected from among the following ones; ##STR2## �rings A and B represent each an unsaturated 5- or 6-membered ring; X represents N(R.sup.2), (wherein R.sup.2 represents hydrogen or lower alkyl), or NHCO; Y represents O, S(O).sub.n, C(R.sup.3)(R.sup.4), C(O), N(R.sup.5), CH(R.sup.6)CH(R.sup.7), C(R.sup.8).dbd.C(R.sup.9), N(R.sup.10)C(O), N.dbd.C(R.sup.11), OCH(R.sup.12), S(O).sub.n CH(R.sup.13) or N(R.sup.14)CH(R.sup.15); Z represents nitrogen or C(R.sup.16) (n represents 0, 1 or 2, R.sup.3 to R.sup.13, R.sup.15 and R.sup.16 each represents hydrogen or lower alkyl, and R.sup.14 represents hydrogen, lower alkyl or lowver acyl.)!}
摘要翻译: PCT No.PCT / JP94 / 01231 Sec。 371日期:1995年3月23日 102(e)1995年3月23日PCT PCT 1994年7月26日PCT公布。 出版物WO95 / 03279 日期1995年2月2日提供了具有各自抗肿瘤作用并由以下通式(I)表示的三环杂环磺酰胺衍生物和磺酸酯衍生物及其制备方法。 这些化合物各具有优异的抗肿瘤活性。 由以下通式(I)表示的磺酰胺衍生物或磺酸酯衍生物:元环; L表示0或-N(R1) - (R1表示氢或低级烷基); M表示选自以下的三环结构: (a)
(b) [环A和B各自表示不饱和的5-或6-元环; X表示N(R2),(其中R2表示氢或低级烷基)或NHCO; Y表示O,S(O)n,C(R3)(R4),C(O),N(R5),CH(R6)CH(R7),C(R8)= C(R9) )C(O),N = C(R 11),OCH(R 12),S(O)n CH(R 13)或N(R 14)CH(R 15) Z表示氮或C(R16)(n表示0,1或2,R3至R13,R15和R16各自表示氢或低级烷基,R14表示氢,低级烷基或低级酰基)]}
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