摘要:
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 etc, R1 is a group of the formula: RaSO2NH— etc, Ra is an alkyl group etc, R2 and R3 are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group etc, X is an oxygen atom etc, Y is a group of the formula: —C(═O)— etc, Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group, Q is a single bond, an alkylene group etc, or a pharmaceutically acceptable salt thereof.
摘要翻译:本发明涉及可用作以下式[I]的盐皮质激素受体调节剂的化合物:其中环A为任选具有除R1等以外的取代基的苯环,R1为 式:R a SO 2 NH-等,R a为烷基等,R 2和R 3各自为氢原子,苯基,任意取代的烷基等,X为氧原子等,Y为下式基团-C (= O) - 等,Ar为任选取代的芳基或任选取代的杂芳基,Q为单键,亚烷基等,或其药学上可接受的盐。
摘要:
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 etc, R1 is a group of the formula: RaSO2NH— etc, Ra is an alkyl group etc, R2 and R3 are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group etc, X is an oxygen atom etc, Y is a group of the formula: —C(═O)— etc, Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group, Q is a single bond, an alkylene group etc, or a pharmaceutically acceptable salt thereof.
摘要翻译:本发明涉及可用作以下式[I]的盐皮质激素受体调节剂的化合物:其中环A为任选具有除R1等以外的取代基的苯环,R1为 式:R a SO 2 NH-等,R a为烷基等,R 2和R 3各自为氢原子,苯基,任意取代的烷基等,X为氧原子等,Y为下式基团-C (= O) - 等,Ar为任选取代的芳基或任选取代的杂芳基,Q为单键,亚烷基等,或其药学上可接受的盐。
摘要:
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 etc, R1 is a group of the formula: RaSO2NH— etc, Ra is an alkyl group etc, R2 and R3 are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group etc, X is an oxygen atom etc, Y is a group of the formula: —C(═O)— etc, Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group, Q is a single bond, an alkylene group etc, or a pharmaceutically acceptable salt thereof.
摘要翻译:本发明涉及可用作以下式[I]的盐皮质激素受体调节剂的化合物:其中环A为任选具有除R1等以外的取代基的苯环,R1为 式:R a SO 2 NH-等,R a为烷基等,R 2和R 3各自为氢原子,苯基,任意取代的烷基等,X为氧原子等,Y为下式基团-C (-O) - 等,Ar是任选取代的芳基或任选取代的杂芳基,Q是单键,亚烷基等,或其药学上可接受的盐。
摘要:
The present invention relates to a compound, useful as a mineralocorticoid receptor-modulating agent, of the following formula [I]: wherein Ring A is a benzene ring optionally having a substituent(s) other than R1 etc, R1 is a group of the formula: RaSO2NH— etc, Ra is an alkyl group etc, R2 and R3 are each a hydrogen atom, a phenyl group, an optionally substituted alkyl group etc, X is an oxygen atom etc, Y is a group of the formula: —C(═O)— etc, Ar is an optionally substituted aryl group or an optionally substituted heteroaryl group, Q is a single bond, an alkylene group etc, or a pharmaceutically acceptable salt thereof.
摘要翻译:本发明涉及可用作以下式[I]的盐皮质激素受体调节剂的化合物:其中环A为任选具有除R1等以外的取代基的苯环,R1为 式:R a SO 2 NH-等,R a为烷基等,R 2和R 3各自为氢原子,苯基,任意取代的烷基等,X为氧原子等,Y为下式基团-C (= O) - 等,Ar为任选取代的芳基或任选取代的杂芳基,Q为单键,亚烷基等,或其药学上可接受的盐。
摘要:
The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.
摘要翻译:本发明提供式(I)的缩合呋喃化合物:其中环X为苯,吡啶等; Y是任选取代的氨基,任选取代的环烷基,任选取代的芳基,任选取代的饱和杂环基,任选取代的不饱和杂环基; A是单键,低级亚烷基,低级亚烯基,低级亚烯基或氧原子; R 3是氢等; 和R 4是氢等,或其药学上可接受的盐,其可用作药物,特别是作为活化凝血因子X抑制剂。
摘要:
The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and, R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.
摘要:
The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.
摘要:
The present invention provides an amide-type carboxamide derivative of the formula [1]: wherein X is a group of the formula: —N═ or the formula: —CH═; R1 is a halogen atom, a lower alkyl group, and the like; R2 is a group of the formula: and the like; Y1 and Y2 are the same or different and each is a group selected from a halogen atom, a lower alkyl group, a lower alkoxy group, and the like; Ring A is phenyl group, and the like, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of FXa.
摘要翻译:本发明提供式[1]的酰胺型羧酰胺衍生物:其中X是下式的基团:-N-或式:-CH-; R 1是卤素原子,低级烷基等; R 2是下式的基团:等等; Y 1和Y 2相同或不同,各自为选自卤素原子,低级烷基,低级烷氧基等的基团; 环A是可用作FXa抑制剂的苯基等,或其药学上可接受的盐。
摘要:
The present invention provides an amide-type carboxamide derivative of the formula [1]: wherein X is a group of the formula: —N═ or the formula: —CH═; R1 is a halogen atom, a lower alkyl group, and the like; R2 is a group of the formula: and the like; Y1 and Y2 are the same or different and each is a group selected from a halogen atom, a lower alkyl group, a lower alkoxy group, and the like; Ring A is phenyl group, and the like, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of FXa.
摘要翻译:本发明提供式[1]的酰胺型羧酰胺衍生物:其中X是下式的基团:-N-或式:-CH-; R 1是卤素原子,低级烷基等; R 2是下式的基团:等等; Y 1和Y 2相同或不同,各自为选自卤素原子,低级烷基,低级烷氧基等的基团; 环A是可用作FXa抑制剂的苯基等,或其药学上可接受的盐。
摘要:
The present invention provides a morpholine derivative of the formula [I]; wherein R1 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; R2 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R3, R4, R5 and R6 are the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group; or pharmaceutically acceptable salts thereof. These compounds are useful as a renin inhibitor.
摘要翻译:本发明提供式[I]的吗啉衍生物。 其中R1是取代的烷基,任选取代的芳基,任选取代的杂环基,环烷基或烷基; R 2是取代的烷基,任选取代的芳基,任选取代的杂环基,任选取代的烷基羰基,任选取代的芳基羰基,任选取代的杂环取代的羰基或环烷基羰基; T是亚甲基或羰基; R3,R4,R5和R6相同或不同,氢原子,任选取代的氨基甲酰基或任选取代的烷基; 或其药学上可接受的盐。 这些化合物可用作肾素抑制剂。