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公开(公告)号：US5824339A
公开(公告)日：1998-10-20
申请号：US708663
申请日：1996-09-05
IPC分类号： A61K9/46
CPC分类号： A61K9/0007
摘要： An effervescent composition comprising a core-shell powder consisting of a fine granular core spray-coated with a liquid mixture containing a water-soluble polymer such as hydroxypropylcellulose or hydroxypropylmethylcellulose, and at least one physiologically active substance, especially an acid-sensitive drugs, and enteric coating film, an effervescing component and an auxiliary effervescing agent which provides for controlled release of the physiologically active substance and in useful for preparing uniform solution or suspension having a refreshing sensation on ingestion.
摘要翻译： 一种泡腾组合物，其包含由喷雾涂覆有含有水溶性聚合物如羟丙基纤维素或羟丙基甲基纤维素的液体混合物的细颗粒核心和至少一种生理活性物质，特别是酸敏感性药物组成的核 - 壳粉末，以及 肠溶衣膜，起泡成分和辅助起泡剂，其提供生理活性物质的控制释放，并且可用于制备具有摄入清爽感的均匀溶液或悬浮液。
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公开(公告)号：US07875292B2
公开(公告)日：2011-01-25
申请号：US12151572
申请日：2008-05-07
CPC分类号： A61K9/28 , A61K9/0056 , A61K9/1611 , A61K9/1652 , A61K9/2081 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K31/4439
摘要： An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 μm or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
摘要翻译： 本发明的口腔崩解片，其特征在于，其包含（i）平均粒径为400μm以下的细颗粒，所述微粒包含通过肠溶衣层包被的组合物，所述组合物的10重量％以上 酸不稳定的生理活性物质和（ii）添加剂，在口腔中具有优异的崩解性或溶解性，因此其可用于治疗或预防各种疾病，作为能够施用于老年人的口腔崩解片剂 儿童，容易无水。 此外，由于本发明的片剂含有平均粒径不会使口腔粗糙的细颗粒，因此在施用时可以容易地施用，而不会不适。
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公开(公告)号：US07431942B2
公开(公告)日：2008-10-07
申请号：US10017755
申请日：2001-10-30
CPC分类号： A61K9/28 , A61K9/0056 , A61K9/1611 , A61K9/1652 , A61K9/2081 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K31/4439
摘要： An orally disintegrable tablet of the present invention, which comprises (i) fine granules having an average particle diameter of 400 μm or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
摘要翻译： 本发明的口腔崩解片，其特征在于，其包含（i）平均粒径为400μm以下的细颗粒，所述微粒包含通过肠溶衣层包被的组合物，所述组合物的10重量％ 酸不稳定的生理活性物质和（ii）添加剂，在口腔中具有优异的崩解性或溶解性，使其可用于治疗或预防各种疾病，作为能够给予老年人或儿童的口服崩解片剂 并且容易地在没有水的情况下施用。 此外，由于本发明的片剂含有平均粒径不会使口腔粗糙的细颗粒，因此在施用时可以容易地施用，而不会不适。
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公开(公告)号：US06328994B1
公开(公告)日：2001-12-11
申请号：US09355781
申请日：1999-08-04
IPC分类号： A61K914
CPC分类号： A61K9/28 , A61K9/0056 , A61K9/1611 , A61K9/1652 , A61K9/2081 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K31/4439
摘要： An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 &mgr;m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
摘要翻译： 本发明的口腔崩解片，其包含（i）平均粒径为400μm以下的细颗粒，所述微粒包含通过肠溶衣层包被的组合物，所述组合物的10重量％以上为 酸不稳定的生理活性物质和（ii）添加剂，在口腔中具有优异的崩解性或溶解性，因此其可用于治疗或预防各种疾病，作为能够施用于老年人的口腔崩解片剂 儿童，容易无水。 此外，由于本发明的片剂含有平均粒径不会使口腔粗糙的细颗粒，因此在施用时可以容易地施用，而不会不适。
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公开(公告)号：US20080292701A1
公开(公告)日：2008-11-27
申请号：US12151572
申请日：2008-05-07
CPC分类号： A61K9/28 , A61K9/0056 , A61K9/1611 , A61K9/1652 , A61K9/2081 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K31/4439
摘要： An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 μm or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
摘要翻译： 本发明的口腔崩解片，其包含（i）平均粒径为400μm以下的细颗粒，所述微粒包含通过肠溶衣层包被的组合物，所述组合物的10重量％以上为 酸不稳定的生理活性物质和（ii）添加剂，在口腔中具有优异的崩解性或溶解性，因此其可用于治疗或预防各种疾病，作为能够施用于老年人的口腔崩解片剂 儿童，容易无水。 此外，由于本发明的片剂含有平均粒径不会使口腔粗糙的细颗粒，因此在施用时可以容易地施用，而不会不适。
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公开(公告)号：US06787082B1
公开(公告)日：2004-09-07
申请号：US09890021
申请日：2001-10-10
申请人： Hikaru Fukuyama , Hiroshi Fukada , Tetsuro Tabata , Etsuji Nakamura , Norio Kameoka , Toshihiro Shimizu
发明人： Hikaru Fukuyama , Hiroshi Fukada , Tetsuro Tabata , Etsuji Nakamura , Norio Kameoka , Toshihiro Shimizu
IPC分类号： B29C4304
CPC分类号： B30B11/08 , B30B15/065
摘要： The punch coated with Cr-Dopé-N is advantageous as a punch for preparing tablets containing an acidic substance or an adhesive substance and is excellent in corrosion resistance and releasing property.
摘要翻译： 用Cr-Dopé-N涂布的冲头作为用于制备含有酸性物质或粘合物质的片剂的冲头是有利的，并且具有优异的耐腐蚀性和脱模性。
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7.发明授权Name identification rule generating apparatus and name identification rule generating method 有权名称识别规则生成装置和名称识别规则生成方法公开(公告)号：US09164980B2
公开(公告)日：2015-10-20
申请号：US13449914
申请日：2012-04-18
申请人： Toshihiro Shimizu
发明人： Toshihiro Shimizu
IPC分类号： G06F17/27
CPC分类号： G06F17/271 , G06F17/278
摘要： A name identification rule generating method, includes: generating an abstract syntax tree by removing a portion of an input sentence unrelated to a process in analysis of syntax of the input sentence by a computer; setting, in generating the abstract syntax tree, nodes corresponding to a plurality of arguments at the same layer; and generating, in generating the abstract syntax tree, a first character string pattern including a second character string corresponding to a node of the abstract syntax tree where a number of types of terminal symbols on the node is equal to or smaller than a certain multiple of a number of types of processes that call the input sentence.
摘要翻译： 一种名称识别规则生成方法，包括：通过移除与计算机对所述输入句子的语法分析过程无关的输入句子的一部分来生成抽象语法树; 在生成抽象语法树时设置与同一层上的多个参数对应的节点; 以及在生成所述抽象语法树时生成包括对应于所述抽象语法树的节点的第二字符串的第一字符串模式，其中所述节点上的多个类型的终端符号等于或小于所述抽象语法树的某个倍数 调用输入句的多种类型的进程。
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公开(公告)号：US09074389B2
公开(公告)日：2015-07-07
申请号：US14234618
申请日：2012-07-05
申请人： Toshihiro Shimizu
发明人： Toshihiro Shimizu
CPC分类号： E05B15/00 , E05B9/04 , E05B13/10 , E05B83/30 , E05B85/14 , E05C9/043 , E05D1/04 , Y10T70/7486
摘要： A lock apparatus includes a housing, a rotor having a bearing portion, rods, a return spring, and a knob having a holding portion and a presser element. The presser element is formed so as to overlap the bearing portion with a predetermined overlap width. When the rods are kept engaged with the engagement portions, a rotating center of the knob is positioned closer to the holding portion than a contact point between the bearing portion and the presser element.
摘要翻译： 锁定装置包括壳体，具有轴承部分的转子，杆，复位弹簧和具有保持部分和压紧元件的旋钮。 压紧元件形成为以预定的重叠宽度与轴承部分重叠。 当杆与接合部分保持接合时，旋钮的旋转中心定位成比轴承部分和压紧元件之间的接触点更靠近保持部分。
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公开(公告)号：US08789863B2
公开(公告)日：2014-07-29
申请号：US13067055
申请日：2011-05-04
申请人： Toshihiro Shimizu
发明人： Toshihiro Shimizu
CPC分类号： E05B83/30 , E05B77/42 , E05B85/02 , E05B85/18 , Y10T292/03 , Y10T292/57
摘要： According to one embodiment, there is provided a lock apparatus, including: a stationary member; a handle rotatably connected to the stationary member via a handle rotating shaft, the handle having a first member; and a damper having a rotor rotatably connected to the stationary member and a second member fixed to the rotor, wherein the first member and the second member are interlocked with each other through a slit and a projection, the slit being provided in either of the first and second members, the projection being provided on the other of the first and second members so as to loosely fit in the slit.
摘要翻译： 根据一个实施例，提供了一种锁定装置，包括：固定构件; 手柄通过手柄旋转轴可旋转地连接到固定构件，手柄具有第一构件; 以及阻尼器，其具有可旋转地连接到所述固定构件的转子和固定到所述转子的第二构件，其中所述第一构件和所述第二构件通过狭缝和突起彼此互锁，所述狭缝设置在所述第一 和第二构件，所述突起设置在所述第一和第二构件中的另一个上，以便松散地配合在所述狭缝中。
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公开(公告)号：US20140008921A1
公开(公告)日：2014-01-09
申请号：US14006301
申请日：2012-02-03
申请人： Toshihiro Shimizu , Satoru Tamaki
发明人： Toshihiro Shimizu , Satoru Tamaki
IPC分类号： E05C9/04
CPC分类号： E05C9/042 , E05B63/14 , E05B63/22 , E05C21/00 , Y10T292/0961
摘要： An openable/closable member locking device includes a mounting base, a pivot, a rotor which is mounted rotatably on the mounting base, a pair of arms, a pair of sliding pins having proximal end portions connected to the arms and distal end portions to be inserted into and dislocated from engagement holes, a torsion coil spring which rotationally urges the rotor such that the sliding pins are inserted into the engagement holes, and a lock release unit which moves the sliding pins against an urging force of the torsion coil spring such that they are dislocated from the engagement holes, and a guide portion is provided which causes the sliding pins to slide straight along a lengthwise direction thereof.
摘要翻译： 可开闭构件锁定装置包括安装座，枢轴，可旋转地安装在安装基座上的转子，一对臂，一对滑动销，其具有连接到臂和远端部分的近端部分， 插入和脱离接合孔的扭转螺旋弹簧，旋转地推动转子使得滑动销插入到接合孔中的扭力螺旋弹簧，以及抵抗扭转螺旋弹簧的推动力使滑动销移动的锁定释放单元，使得 它们从接合孔脱位，并且提供引导部分，其引导滑动销沿其长度方向直线滑动。
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