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    Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
    1.
    发明授权
    Microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms 失效
    能够生产高度不饱和脂肪酸的微生物和通过使用微生物生产高度不饱和脂肪酸的方法

    公开(公告)号：US06582941B1

    公开(公告)日：2003-06-24

    申请号：US08945226

    申请日：1997-12-29

    申请人： Toshihiro Yokochi ,  Toro Nakahara ,  Takanori Higashihara ,  Satohiro Tanaka ,  Toshiaki Yaguchi

    发明人： Toshihiro Yokochi ,  Toro Nakahara ,  Takanori Higashihara ,  Satohiro Tanaka ,  Toshiaki Yaguchi

    IPC分类号： C12N114

    CPC分类号： C12P7/6427 ,  A23K20/158 ,  A23K50/75 ,  A23K50/80 ,  A23L15/00 ,  A23L33/12 ,  C11B1/00 ,  C11C3/00 ,  C12P7/6472 ,  C12R1/645 ,  Y10S435/911 ,  Y10S435/946

    摘要： The present invention relates to the Schizochytrium genus SR21 strain and a microorganism belonging to the same species as does said SR21 strain or having substantially the same fungological properties as does said SR21 strain, the said SR21 strain and microorganism having the ability to produce the (n-3) series of docosahexaenoic acid (DHA) and the (n-6) series of docosapentaenoic acid (DPA), and the invention also relates to a process for preparing the (n-3) series of DHA and the (n-6) series of DPA utilizing said microorganisms. The microorganisms according to the present invention are superior in their proliferation character and their propensity to produce fat, and have the ability to produce the (n-3) series of DHA and the (n-6) series of DPA very well. Accordingly, it is possible to effectively produce the (n-3) series of DHA and/or the (n-6) series of DPA, which are useful in the fields of foods and pharmaceuticals, using the microorganisms according to the present invention. In addition, the present invention provides a fat obtained by culturing the present microorganisms. Since the fat composition contains the (n-6) series of DPA in addition to the (n-3) series of DHA having various physiological activities, it is possible to stably and effectively supply the (n-6) series of DPA and/or the (n-3) series of DHA to subjects in need of these highly unsaturated fatty acids by adding the fat composition to various feedstuffs or foods.

    摘要翻译： 本发明涉及裂殖酵菌属SR21菌株和属于与所述SR21菌株相同种类的微生物或具有与所述SR21菌株基本上相同的真菌性质的微生物，所述SR21菌株和微生物具有产生（n -3）系列二十二碳六烯酸（DHA）和（n-6）系列二十二碳五烯酸（DPA），本发明还涉及一种制备（n-3）系列DHA和（n-6） ）系列的DPA。 根据本发明的微生物的增殖特性及其产生脂肪的倾向是优越的，并且能够非常好地生产（n-3）系列的DHA和（n-6）系列的DPA。 因此，可以使用本发明的微生物有效地生产可用于食品和药物领域的（n-3）系列的DHA和/或（n-6）系列DPA。 此外，本发明提供通过培养本发明的微生物而获得的脂肪。 由于脂肪组合物除了具有各种生理活性的（n-3）系列的DHA以外还含有（n-6）系DPA，所以可以稳定有效地供给（n-6）系列的DPA和/ 或（n-3）系列DHA通过将脂肪组合物添加到各种饲料或食物中来对需要这些高度不饱和脂肪酸的受试者施用。

    Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same
    4.
    发明授权
    Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same 有权
    用于培养微生物的培养基和用于生产不饱和脂肪酸或含有它们的脂质的方法

    公开(公告)号：US06746857B2

    公开(公告)日：2004-06-08

    申请号：US09331759

    申请日：1999-06-25

    申请人： Kenichi Higashiyama ,  Toshiaki Yaguchi ,  Kengo Akimoto ,  Sakayu Shimizu

    发明人： Kenichi Higashiyama ,  Toshiaki Yaguchi ,  Kengo Akimoto ,  Sakayu Shimizu

    IPC分类号： C12P764

    CPC分类号： C12P7/6427 ,  C12N1/14 ,  C12P7/6472

    摘要： A process for controlling the mycelial morphology of a microorganism belonging to the genus Mortierella during culturing and a process for producing unsaturated fatty acids and a lipid containing them by using a culture medium for culturing a microorganism in which phosphate ions, potassium ions, sodium ions, magnesium ions, and calcium ions in the culture medium are in the range of 5 to 60 mM, 5 to 60 mM, 2 to 50 mM, 0.5 to 9 mM, and 0.5 to 12 mM, respectively, characterized in that the microorganism belonging to the genus Mortierella is cultured in a culture medium containing phosphate ions in the range of 5 to 60 mM, potassium ions in the range of 5 to 60 mM, sodium ions in the range of 2 to 50 mM, magnesium ions in the range of 0.5 to 9 mM, and calcium ions in the range of 0.5 to 12 mM, respectively, to produce unsaturated fatty acids and the lipid containing them, and the culture medium for culturing a microorganism having phosphate ions, potassium ions, sodium ions, magnesium ions, and calcium ions in the range of 5 to 60 mM, 5 to 60 mM, 2 to 50 mM, 0.5 to 9 mM, and 0.5 to 12 mM, respectively.

    摘要翻译： 用于在培养期间控制属于被孢霉属属的微生物的菌丝体形态的方法以及通过使用培养基培养不饱和脂肪酸和含有它们的脂质的方法来培养微生物的方法，其中磷酸根离子，钾离子，钠离子， 培养基中的镁离子和钙离子分别为5〜60mM，5〜60mM，2〜50mM，0.5〜9mM，以及0.5〜12mM的范围，其特征在于，属于 将被孢霉属属菌体培养在含有5-60mM磷酸根离子，5-60mM范围钾离子，2-50mM范围内的钠离子，0.5- 至9mM，钙离子分别为0.5-12mM，以产生不饱和脂肪酸和含有它们的脂质，以及用于培养具有磷酸根离子，钾离子，钠离子，镁离子的微生物的培养基 s和钙离子分别在5至60mM，5至60mM，2至50mM，0.5至9mM和0.5至12mM的范围内。

    Triglyceride and composition comprising the same
    5.
    发明授权
    Triglyceride and composition comprising the same 有权
    甘油三酸酯及其组合物

    公开(公告)号：US06248909B1

    公开(公告)日：2001-06-19

    申请号：US09335730

    申请日：1999-06-18

    申请人： Kengo Akimoto ,  Toshiaki Yaguchi ,  Shigeaki Fujikawa

    发明人： Kengo Akimoto ,  Toshiaki Yaguchi ,  Shigeaki Fujikawa

    IPC分类号： C07C5700

    CPC分类号： C07C69/587 ,  A23D9/00 ,  A23K20/158 ,  A23L33/115 ,  C11C3/10 ,  Y10S426/807

    摘要： The present invention provides a novel triglyceride and a composition containing that novel triglyceride having a triglyceride structure of the human breast milk type, which triglyceride has a saturated fatty acid having 16-18 carbon atoms at the position 2, at the position 1 and/or 3; which is and at least one &ohgr;6, &ohgr;9 or &ohgr;3 unsaturated fatty acid manufactured by subjecting a glyceride in which a saturated fatty acid having 16 to 18 carbon atoms is bonded at position 2 to transesterification using a lipase and a &ohgr;6, &ohgr;9 or &ohgr;3-unsaturated fatty acid.

    摘要翻译： 本发明提供一种新颖的甘油三酸酯和含有具有人母乳型甘油三酯结构的新型甘油三酯的组合物，该甘油三酸酯在位置2具有16-18个碳原子的饱和脂肪酸，位置1和/或 3; 其是通过使其中在位置2处键合具有16至18个碳原子的饱和脂肪酸的甘油酯使用脂肪酶和ω6，ω9或ω3-不饱和脂肪酸进行酯交换而制备的至少一种ω6，ω9或ω3不饱和脂肪酸 脂肪酸。

    Utilization of material containing docosapentaenoic acid
    6.
    发明授权
    Utilization of material containing docosapentaenoic acid 有权
    含有二十碳五烯酸的材料的利用

    公开(公告)号：US06596766B1

    公开(公告)日：2003-07-22

    申请号：US09914897

    申请日：2002-01-17

    申请人： Osamu Igarashi ,  Kengo Akimoto ,  Toshiaki Yaguchi ,  Yoshinobu Kiso

    发明人： Osamu Igarashi ,  Kengo Akimoto ,  Toshiaki Yaguchi ,  Yoshinobu Kiso

    IPC分类号： A61K3120

    CPC分类号： A61K31/232 ,  A23D9/00 ,  A23K20/158 ,  A23L33/12 ,  A61K31/202 ,  A61K2300/00

    摘要： A novel technique for relieving arachidonic acid deficient conditions and maintaining a good fatty acid balance in vivo. Utilizaiton of a DPA-containing material for relieving arachidonic acid deficient conditions and maintaining a good fatty acid balance in vivo; and compositions for relieving arachidonic acid deficient conditions and maintaining a good fatty acid balance in vivo which contain a DPA-containing material in an amount efficacious in relieving arachidonic acid deficient conditions and maintaining a good fatty acid balance in vivo per unit dose.

    摘要翻译： 一种减轻花生四烯酸缺乏条件并保持体内良好脂肪酸平衡的新技术。 用于减少花生四烯酸缺乏条件并维持体内良好的脂肪酸平衡的含DPA的材料; 以及用于缓解花生四烯酸缺乏条件并保持体内良好脂肪酸平衡的组合物，其含有含量为DPA的材料，其量有效地缓解了花生四烯酸缺乏条件并维持每单位剂量的体内良好的脂肪酸平衡。