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公开(公告)号:US5110960A
公开(公告)日:1992-05-05
申请号:US590721
申请日:1990-10-01
申请人: Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
发明人: Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
IPC分类号: C07H15/244 , C12P19/56
CPC分类号: C12R1/03 , C07H15/244 , C12P19/56
摘要: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
摘要翻译: 本文命名为BU-3608,BU-3608B和BU-3608C的新型抗生素通过发行Actinomadura hibisca菌株P157-2,ATCC 53557和菌株Q278-4,ATCC 53646产生。抗生素具有 抗真菌和抗病毒活性。
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公开(公告)号:US4990497A
公开(公告)日:1991-02-05
申请号:US366573
申请日:1989-06-15
申请人: Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
发明人: Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
IPC分类号: C07H15/244 , C12P19/56
CPC分类号: C12R1/03 , C07H15/244 , C12P19/56
摘要: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
摘要翻译: 本文命名为BU-3608,BU-3608B和BU-3608C的新型抗生素通过发行Actinomadura hibisca菌株P157-2,ATCC 53557和菌株Q278-4,ATCC 53646产生。抗生素具有 抗真菌和抗病毒活性。
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公开(公告)号:US4870165A
公开(公告)日:1989-09-26
申请号:US115273
申请日:1987-11-02
申请人: Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
发明人: Toshikazu Oki , Kyoichiro Saitoh , Kozo Tomatsu , Koji Tomita , Masataka Konishi , Takeo Miyaki , Mitsuaki Tsunakawa , Maki Nishio
IPC分类号: A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P31/10 , A61P31/12 , C07C235/84 , C07H15/24 , C07H15/244 , C07H15/256 , C12N1/20 , C12P19/56 , C12R1/03
CPC分类号: C12R1/03 , C07H15/244 , C12P19/56
摘要: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
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公开(公告)号:US4792545A
公开(公告)日:1988-12-20
申请号:US817212
申请日:1986-01-08
IPC分类号: C07H15/234 , C12P19/46 , A61K31/71 , C07H15/20
CPC分类号: C07H15/234 , C12P19/46
摘要: Boholmycin antibiotic is prepared by fermentation of Streptomyces hygroscopicus H617-25 (ATCC No. 53240) in a nutrient medium preferably comprising glycerol, bacto-liver, cornsteep liquor, ammonium sulfate, sodium chloride and calcium carbonate. The antibiotic and pharmaceutically acceptable salts and hydrates thereof and compositions containing these are effective against Gram-positive, Gram-negative and acid-fast bacteria and against bacterial strains which are resistant to previously known aminoglycoside antibiotics and are useful to treat bacterial infections in mammals.
摘要翻译: 通过在优选包含甘油,细菌肝,玉米浸液,硫酸铵,氯化钠和碳酸钙的营养培养基中发酵吸水链霉菌H617-25(ATCC No.53240)来制备博尔霉素抗生素。 抗生素及其药学上可接受的盐和水合物以及含有它们的组合物对革兰氏阳性,革兰氏阴性和酸性抗菌细菌和对先前已知的氨基糖苷类抗生素具有抗性的细菌菌株是有效的,并且可用于治疗哺乳动物的细菌感染。
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公开(公告)号:US5098708A
公开(公告)日:1992-03-24
申请号:US546463
申请日:1990-07-06
IPC分类号: C12P1/06
CPC分类号: C12P1/06 , Y10S435/822 , Y10S435/826
摘要: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译: 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1,A2,A3,D1,D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒,人类免疫缺陷病毒(HIV)和流感病毒在内的病毒。
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公开(公告)号:US5286649A
公开(公告)日:1994-02-15
申请号:US819543
申请日:1992-01-10
CPC分类号: C12P1/06 , Y10S435/822
摘要: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译: 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1,A2,A3,D1,D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒,人类免疫缺陷病毒(HIV)和流感病毒在内的病毒。
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公开(公告)号:US5124150A
公开(公告)日:1992-06-23
申请号:US624029
申请日:1991-03-11
IPC分类号: C12P1/06
CPC分类号: C12P1/06 , Y10S435/822
摘要: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译: 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1,A2,A3,D1,D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒,人类免疫缺陷病毒(HIV)和流感病毒在内的病毒。
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公开(公告)号:US5843908A
公开(公告)日:1998-12-01
申请号:US589728
申请日:1990-09-28
申请人: Yosuke Sawada , Kyoichiro Saitoh , Masami Hatori , Takeo Miyaki , Toshikazu Oki , Koji Tomita
发明人: Yosuke Sawada , Kyoichiro Saitoh , Masami Hatori , Takeo Miyaki , Toshikazu Oki , Koji Tomita
IPC分类号: C07H15/24 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P31/10 , C07H15/244 , C12N1/20 , C12P19/56 , C12R1/03
CPC分类号: C07H15/244
摘要: The present invention relates to novel antifungal antibiotics herein designated as pradimicin L and pradimicin FL, and derivatives thereof. Pradimicins L and FL are produced by Actinomadura verrucosospora subsp. neohibisca strain R103-3, ATCC No. 53930.
摘要翻译: 本发明涉及本文中称为普拉定霉素L和普拉定霉素FL的新型抗真菌抗生素及其衍生物。 Pradimicins L和FL由Actinomadura verrucosospora subsp。 新罗非鱼菌株R103-3,ATCC No.53930。
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公开(公告)号:US4956374A
公开(公告)日:1990-09-11
申请号:US226016
申请日:1988-07-29
申请人: Maki Nishio , Shigeyuki Ando , Takeo Miyaki , Masataka Konishi , Toshikazu Oki
发明人: Maki Nishio , Shigeyuki Ando , Takeo Miyaki , Masataka Konishi , Toshikazu Oki
IPC分类号: C07D417/04 , C12P17/16
CPC分类号: C07D417/04 , C12P17/16 , C12R1/01
摘要: Novel antifungal antibiotic compounds have the structural formula ##STR1## A preferred compound where R is 4-hydroxypentyl is denoted BU-3557B.sub.2. A complex of said compounds is produced by fermenting a culture of Sacchrothrix aerocolonigenes strain N806-4 (ATCC 53712). The complex is recovered by adsorption on nonionic porous polymer resin adsorbent and individual component compounds exhibit in vitro activity against fungi and Gram-positive bacteria and BU-3557B.sub.2 demonstrates in vitro antiprotazoal activity. BU-3557B.sub.2 demonstrates in vivo activity against C. albicans vaginal infection and BU-3557A.sub.3 (where R is 1,5-dihydroxy-5,5-dimethylpentyl) demonstrates in vivo activity against C. albicans systemic infection.
摘要翻译: 新型抗真菌抗生素化合物具有结构式:其中R为4-羟基戊基的优选化合物为BU-3557B2。 通过发酵产气荚膜梭菌菌株N806-4(ATCC 53712)的培养物产生所述化合物的复合物。 通过非离子多孔聚合物树脂吸附剂上的吸附回收复合物,并且各组分化合物表现出对真菌和革兰氏阳性细菌的体外活性,并且BU-3557B2证明体外抗原辅素生物活性。 BU-3557B2证明体内活性针对白色念珠菌阴道感染和BU-3557A3(其中R为1,5-二羟基-5,5-二甲基戊基)表现出对白色念珠菌全身感染的体内活性。
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公开(公告)号:US4927848A
公开(公告)日:1990-05-22
申请号:US246393
申请日:1988-09-19
申请人: Masataka Konishi , Keiko Shimizu , Masaru Ohbayashi , Koji Tomita , Takeo Miyaki , Toshikazu Oki
发明人: Masataka Konishi , Keiko Shimizu , Masaru Ohbayashi , Koji Tomita , Takeo Miyaki , Toshikazu Oki
IPC分类号: C07D311/78
CPC分类号: C07D311/78
摘要: A new antibiotic having the chromophore structure of the pluramycin family of antibiotics is produced by fermentation of Streptomyces ciolaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the growth of tumors in experimental animal systems.
摘要翻译: 具有抗生素普拉霉素家族的发色团结构的新型抗生素通过发酵链霉菌ATCC 53807产生。命名为BU-3839T的新型抗生素显示出有效的抗菌活性并且还抑制实验动物系统中肿瘤的生长。
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