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    Phenylpyrazole derivatives
    2.
    发明授权
    Phenylpyrazole derivatives 有权
    苯基吡唑衍生物

    公开(公告)号：US08183387B2

    公开(公告)日：2012-05-22

    申请号：US12951964

    申请日：2010-11-22

    申请人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

    发明人： Toshio Nakamura ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

    IPC分类号： C07D231/10

    CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

    摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

    摘要翻译： 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

    PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES
    10.
    发明申请
    PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES 失效
    吡咯并嘧啶和吡咯烷酮衍生物

    公开(公告)号：US20110137031A1

    公开(公告)日：2011-06-09

    申请号：US10584946

    申请日：2005-01-06

    申请人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    发明人： Atsuro Nakazato ,  Taketoshi Okubo ,  Dai Nozawa ,  Tomoko Tamita ,  Ludo E.J. Kennis

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

    摘要翻译： 本发明的目的是提供一种抗CRF受体的拮抗剂，其作为治疗或预防药物是有效的，其涉及CRF被认为涉及的疾病，例如抑郁症，焦虑症，阿尔茨海默氏病，帕金森病，亨廷顿氏舞蹈病，进食 疾病，高血压，胃疾病，药物依赖，癫痫，脑梗塞，脑缺血，脑水肿，头部外伤，炎症，免疫相关疾病，特异性，肠易激综合征，睡眠障碍，皮肤病，精神分裂症，疼痛等。 由下式[I]表示的氨基甲酰基取代的吡咯并嘧啶或吡咯并三嗪衍生物：对CRF受体具有高亲和力，并且对于认为涉及CRF的疾病是有效的。