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    System and Method for Plasma Reduced Platelet Collection
    1.
    发明申请
    System and Method for Plasma Reduced Platelet Collection 有权
    血浆减少血小板收集的系统和方法

    公开(公告)号：US20090259162A1

    公开(公告)日：2009-10-15

    申请号：US12102486

    申请日：2008-04-14

    申请人： Toshiyasu Ohashi ,  Etienne Pages ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

    发明人： Toshiyasu Ohashi ,  Etienne Pages ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

    IPC分类号： A61M1/38

    CPC分类号： A61M1/0263 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/0259 ,  A61M1/0272 ,  A61M1/029 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/382 ,  A61M2202/0413 ,  A61M2202/0427

    摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.

    摘要翻译： 一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。 从供体抽出全血并引入分离室。 使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。 分离室中的剩余血液成分返回给供体。 将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。 将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。

    System and method for plasma reduced platelet collection
    2.
    发明授权
    System and method for plasma reduced platelet collection 有权
    血浆减少血小板收集的系统和方法

    公开(公告)号：US08454548B2

    公开(公告)日：2013-06-04

    申请号：US12102486

    申请日：2008-04-14

    申请人： Toshiyasu Ohashi ,  Etienne Pagès ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

    发明人： Toshiyasu Ohashi ,  Etienne Pagès ,  Dominique Uhlmann ,  Pascal Maillard ,  Michael Ragusa

    IPC分类号： A61M37/00 ,  A61M1/36 ,  A61M1/38 ,  B01D36/00

    CPC分类号： A61M1/0263 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/0259 ,  A61M1/0272 ,  A61M1/029 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/382 ,  A61M2202/0413 ,  A61M2202/0427

    摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.

    摘要翻译： 一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。 从供体抽出全血并引入分离室。 使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。 分离室中的剩余血液成分返回给供体。 将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。 将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。

    Three-Line Apheresis System and Method
    4.
    发明申请
    Three-Line Apheresis System and Method 有权
    三线单采系统与方法

    公开(公告)号：US20090259163A1

    公开(公告)日：2009-10-15

    申请号：US12102407

    申请日：2008-04-14

    申请人： Etienne Pages ,  Michael Ragusa

    发明人： Etienne Pages ,  Michael Ragusa

    IPC分类号： A61M1/14

    CPC分类号： A61M1/367 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/303 ,  A61M1/304 ,  A61M1/3601 ,  A61M1/3603 ,  A61M1/3604 ,  A61M1/3621 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/387 ,  A61M2202/0071

    摘要： A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line connected to an anticoagulant source, introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. A draw pump, an anticoagulant pump, and a return pump, respectively control the flows through the draw line, anticoagulant line, and the return line. The blood component separation device separates the drawn blood into a first blood component and a second blood component. The blood component separation device also may be configured to send the first blood component to a first blood component bag.

    摘要翻译： 用于收集和交换血液成分的血液处理系统包括用于从对象抽取全血并将血液成分返回到受试者的静脉通路装置。 该系统还可以包括将静脉进入装置连接到血液成分分离装置和抗凝血剂源的三条线。 血液抽吸管线与静脉通路装置流体连接到血液成分分离装置。 连接抗凝血源的抗凝血剂线，将抗凝血剂引入到全血中。 流体地连接到静脉通路装置和血液成分分离装置的返回管线，并将未收集的血液成分返回给受试者。 抽水泵，抗凝血泵和回流泵分别控制通过牵引线，抗凝血线和回流管线的流量。 血液成分分离装置将抽取的血液分离为第一血液成分和第二血液成分。 血液成分分离装置还可以构造成将第一血液成分发送到第一血液成分袋。

    Blood component separation system with stationary separation chamber
    5.
    发明申请
    Blood component separation system with stationary separation chamber 审中-公开
    血液成分分离系统与固定分离室

    公开(公告)号：US20060058167A1

    公开(公告)日：2006-03-16

    申请号：US11167784

    申请日：2005-06-27

    申请人： Michael Ragusa ,  Gary Stacey ,  Etienne Pages

    发明人： Michael Ragusa ,  Gary Stacey ,  Etienne Pages

    IPC分类号： B04B11/02

    CPC分类号： G02B27/42 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  A61M1/3696 ,  G02B21/32 ,  G02B27/4205

    摘要： Provided is a blood processing system having a stationary component separation chamber. Individual blood components as well as other particles and contaminates are separated from blood flowing through the separation chamber by optical traps configured to manipulate specific components are projected into the flow field of the chamber. Cells or particles of the selected components that are manipulated by the optical traps then may be directed from the flow field to individual reservoirs to collect quantities of the selected components.

    摘要翻译： 提供了一种具有静止部件分离室的血液处理系统。 单独的血液成分以及其它颗粒和污染物与通过配置成操纵特定组分的光学捕集器流经分离室的血液分离，投射到腔室的流场中。 然后由光学捕集器操纵的所选择的组分的细胞或颗粒可以从流场引导到各个储存器以收集大量的所选择的组分。

    System and Method for Optimized Apheresis Draw and Return
    6.
    发明申请
    System and Method for Optimized Apheresis Draw and Return 有权
    优化抽选和回报的系统和方法

    公开(公告)号：US20090259164A1

    公开(公告)日：2009-10-15

    申请号：US12102427

    申请日：2008-04-14

    申请人： Etienne Pages ,  Michael Ragusa

    发明人： Etienne Pages ,  Michael Ragusa

    IPC分类号： A61M1/34

    CPC分类号： A61M1/30 ,  A61M1/024 ,  A61M1/0245 ,  A61M1/14 ,  A61M1/1601 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/3472 ,  A61M1/36 ,  A61M1/3607 ,  A61M1/3621 ,  A61M1/3639 ,  A61M1/3663 ,  A61M1/3679 ,  A61M1/382 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3379 ,  A61M2205/3393

    摘要： A blood processing device for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning unused blood components to the subject. The system may also include a blood component separation device that separates the drawn whole blood into a first blood component and a second blood component. The blood component separation device may also be configured to send the second blood component to a second blood component storage container. The system may use a return line that fluidly connects the venous-access device and the blood component separation device to return the first blood component to the subject. The system may also have a first and second pressure sensor located on the return line. The first pressure sensor may be located between the blood component separation device and the venous-access device and may determine a first pressure within the return line. The second pressure sensor may be located on the return line between the first pressure sensor and the venous-access device and may determine a second pressure within the return line. A pump connected to the return line may control the return flow rate within the return line based on a subject access pressure determined based on the first pressure and the second pressure.

    摘要翻译： 用于收集和交换血液成分的血液处理装置包括用于从对象抽取全血并将未使用的血液成分返回给对象的静脉通路装置。 该系统还可以包括血液成分分离装置，其将抽取的全血分离成第一血液成分和第二血液成分。 血液成分分离装置也可以构成为将第二血液成分送到第二血液成分储存容器。 系统可以使用流体连接静脉通路装置和血液成分分离装置的返回管线，以将第一血液成分返回给对象。 系统还可以具有位于返回管线上的第一和第二压力传感器。 第一压力传感器可以位于血液成分分离装置和静脉通路装置之间，并且可以确定回流管线内的第一压力。 第二压力传感器可以位于第一压力传感器和静脉通路装置之间的返回管线上，并且可以确定返回管线内的第二压力。 连接到返回管路的泵可以基于基于第一压力和第二压力确定的对象进入压力来控制返回管线内的返回流量。

    Three-line apheresis system and method
    7.
    发明授权
    Three-line apheresis system and method 有权
    三线血液分离系统及方法

    公开(公告)号：US08628489B2

    公开(公告)日：2014-01-14

    申请号：US12102407

    申请日：2008-04-14

    申请人： Etienne Pagès ,  Michael Ragusa

    发明人： Etienne Pagès ,  Michael Ragusa

    IPC分类号： A61M37/00 ,  A61M1/00 ,  A61M1/14 ,  A61M1/36

    CPC分类号： A61M1/367 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/303 ,  A61M1/304 ,  A61M1/3601 ,  A61M1/3603 ,  A61M1/3604 ,  A61M1/3621 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/387 ,  A61M2202/0071

    摘要： A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. Each line may have a pump that controls flow through the line. The blood component separation device separates the drawn blood into a first blood component and a second blood component, and may be configured to send the first blood component to a first blood component bag.

    摘要翻译： 用于收集和交换血液成分的血液处理系统包括用于从对象抽取全血并将血液成分返回到受试者的静脉通路装置。 该系统还可以包括将静脉进入装置连接到血液成分分离装置和抗凝血剂源的三条线。 血液抽吸管线与静脉通路装置流体连接到血液成分分离装置。 抗凝血剂线将抗凝血剂引入全血中。 流体地连接到静脉通路装置和血液成分分离装置的返回管线，并将未收集的血液成分返回给受试者。 每条线路可能都有一个泵来控制通过管路的流量。 血液成分分离装置将抽取的血液分离成第一血液成分和第二血液成分，并且可以将第一血液成分发送到第一血液成分袋。