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    Amylase inhibitors
    2.
    发明授权
    Amylase inhibitors 失效
    淀粉酶抑制剂

    公开(公告)号：US5444046A

    公开(公告)日：1995-08-22

    申请号：US216846

    申请日：1994-03-24

    申请人： Toshiyuki Miyazaki ,  Toshihisa Morimoto ,  Ryuji Murayama ,  Hiroshi Matsubara

    发明人： Toshiyuki Miyazaki ,  Toshihisa Morimoto ,  Ryuji Murayama ,  Hiroshi Matsubara

    IPC分类号： A23J1/12 ,  A23J3/18 ,  A61K38/00 ,  C07K14/415 ,  A61K38/16 ,  C07K1/18

    CPC分类号： C07K14/415 ,  A23J1/12 ,  A23J3/18 ,  A61K38/00

    摘要： An amylase inhibitor consisting essentially of a protein constructed of 248 amino acid residues having two subunits, each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis. The amylase inhibitor can be extracted from wheat and purified by absorption on a cation exchange resin. It is useful for inhibiting an increase in blood glucose level, controlling insulin secretion, suppressing appetite, and as a food additive. The new amylase inhibitor can be used in combination with a protein composed of two subunits, each identified as SEQ ID NO:2, the total content of both proteins being not less than 20% by weight.

    摘要翻译： 淀粉酶抑制剂基本上由具有248个氨基酸残基构成的蛋白质组成，其具有两个亚基，每个被鉴定为SEQ ID NO：1，其中通过聚丙烯酰胺凝胶电泳以0.26的迁移率观察到单个条带。 可以从小麦中提取淀粉酶抑制剂，并通过在阳离子交换树脂上吸收进行纯化。 抑制血糖水平升高，抑制胰岛素分泌，抑制食欲，以及作为食品添加剂是有用的。 新的淀粉酶抑制剂可与由两个亚基组成的蛋白质组合使用，每个亚基各自鉴定为SEQ ID NO：2，两种蛋白质的总含量不小于20重量％。

    Processes for the preparation of amylase inhibitor
    4.
    发明授权
    Processes for the preparation of amylase inhibitor 失效
    制备淀粉酶抑制剂的方法

    公开(公告)号：US5332803A

    公开(公告)日：1994-07-26

    申请号：US49180

    申请日：1993-04-19

    申请人： Toshiyuki Miyazaki ,  Ryuji Murayama ,  Toshihisa Morimoto

    发明人： Toshiyuki Miyazaki ,  Ryuji Murayama ,  Toshihisa Morimoto

    IPC分类号： A61K38/55 ,  A23L29/00 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/00 ,  C07K1/14 ,  C07K1/18 ,  C07K1/32 ,  C07K14/415 ,  C12N9/99 ,  C07K3/02 ,  C07K3/24 ,  C07K3/28 ,  C07K15/10

    CPC分类号： C07K14/415 ,  A23L29/03 ,  A61K38/005

    摘要： A process for the preparation of an amylase inhibitor is disclosed which comprises the steps of:(a) extracting wheat, wheat flour or wheat gluten with water, a dilute acid, a dilute alkali or an aqueous alcohol to produce a solution containing the amylase inhibitor;(b) adding a polysaccharide to said solution to form an insoluble complex of the amylase inhibitor with the polysaccharide and separating the insoluble complex from the solution;(c) dissolving or dispersing said complex in a solution, then separating the polysaccharide from the solution to collect a solution containing the amylase inhibitor; and(d) treating the collected solution with a cation exchanger to recover the amylase inhibitor from fractions that have not been adsorbed on the cation exchanger.The amylase inhibitors produced by the above process possess a high amylase inhibitory activity but substantially no trypsin inhibitory activity, and are useful in the prophylaxis and treatment of diseases such as hyperglycemia, diabetes, hyperlipemia, arteriosclerosis and obesity.

    摘要翻译： 公开了一种制备淀粉酶抑制剂的方法，其包括以下步骤：（a）用水，稀酸，稀碱或含水醇提取小麦，小麦粉或小麦面筋以产生含有淀粉酶抑制剂的溶液 ; （b）向所述溶液中加入多糖以形成淀粉酶抑制剂与多糖的不溶性络合物，并从溶液中分离不溶性络合物; （c）将所述复合物溶解或分散在溶液中，然后从溶液中分离多糖以收集含有淀粉酶抑制剂的溶液; 和（d）用阳离子交换剂处理收集的溶液，以从未吸附在阳离子交换器上的级分回收淀粉酶抑制剂。 通过上述方法制备的淀粉酶抑制剂具有高淀粉酶抑制活性，但基本上没有胰蛋白酶抑制活性，并且可用于预防和治疗高血糖症，糖尿病，高脂血症，动脉硬化和肥胖症等疾病。

    Amylase inhibitors
    5.
    发明授权
    Amylase inhibitors 失效
    淀粉酶抑制剂

    公开(公告)号：US5726291A

    公开(公告)日：1998-03-10

    申请号：US782176

    申请日：1997-01-14

    申请人： Toshiyuki Miyazaki ,  Toshihisa Morimoto ,  Ryuji Murayama

    发明人： Toshiyuki Miyazaki ,  Toshihisa Morimoto ,  Ryuji Murayama

    IPC分类号： A23L1/30 ,  A23L1/305 ,  A23L1/307 ,  A61K38/00 ,  A61K38/55 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K14/415 ,  C07K3/02 ,  A61K38/16 ,  C07K3/24 ,  C07K15/10

    CPC分类号： C07K14/415 ,  A23L33/17 ,  A61K38/00

    摘要： An amylase inhibitor consisting of a protein constructed of 244 amino acid residues having two subunits each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis, and having a high inhibitory activity against human pancreatic .alpha.-amylase to inhibit an increase in blood glucose level, control an insulin secretion or maintain the duration in a feeling of satiety for diet. The amylase inhibitor can be used alone or in combination with other known amylase inhibitors.

    摘要翻译： 由由244个氨基酸残基构成的蛋白质组成的淀粉酶抑制剂，其具有两个各自鉴定为SEQ ID NO：1的亚基，其中通过聚丙烯酰胺凝胶电泳以0.26的迁移率观察到单个条带，并且对人体具有高的抑制活性 胰腺α-淀粉酶以抑制血糖水平的升高，控制胰岛素分泌或维持持续时间对于饮食的饱腹感。 淀粉酶抑制剂可以单独使用或与其它已知的淀粉酶抑制剂组合使用。

    Radar reception signal processing apparatus and method thereof
    6.
    发明授权
    Radar reception signal processing apparatus and method thereof 有权
    雷达接收信号处理装置及其方法

    公开(公告)号：US08742983B2

    公开(公告)日：2014-06-03

    申请号：US13338641

    申请日：2011-12-28

    申请人： Junichiro Suzuki ,  Toshiyuki Miyazaki ,  Mitsuyoshi Shinonaga

    发明人： Junichiro Suzuki ,  Toshiyuki Miyazaki ,  Mitsuyoshi Shinonaga

    IPC分类号： G01S13/00

    CPC分类号： G01S7/292 ,  G01S7/295 ,  G01S13/5246

    摘要： According to one embodiment, a calculating of a weight includes which is calculating a covariance matrix by applying a process (Post-Doppler process) of selecting a plurality of banks after execution of a Doppler filter process to a specified number of pulses of the received signal, and extracting a plurality of arbitrary bank parts from among the plurality of selected banks which are used for the calculation of the covariance matrix, and calculating a plurality of weights on a phase and an amplitude, from a matrix of the plurality of extracted bank parts.

    摘要翻译： 根据一个实施例，权重的计算包括：通过将执行多普勒滤波处理之后的多个存储体中选择多个存储体的处理（后多普勒处理）计算到接收信号的指定数目的脉冲数来计算协方差矩阵 并且从用于计算协方差矩阵的多个选择的组中提取多个任意存储体部分，并且从多个提取的存储体部分的矩阵中计算相位和幅度上的多个权重 。

    Speech recognition device for recognizing a word sequence using a switching speech model network
    7.
    发明授权
    Speech recognition device for recognizing a word sequence using a switching speech model network 失效
    用于使用切换语音模型网络识别字序列的语音识别装置

    公开(公告)号：US07487091B2

    公开(公告)日：2009-02-03

    申请号：US10513753

    申请日：2003-05-07

    申请人： Toshiyuki Miyazaki

    发明人： Toshiyuki Miyazaki

    IPC分类号： G10L15/00 ,  G10L15/28 ,  G10L15/14

    CPC分类号： G10L15/08 ,  G10L15/142 ,  G10L15/193 ,  G10L15/285

    摘要： A speech recognition device which can preferably be used for reducing the memory capacity required for speaker-independent speech recognition is provided. A matching unit loads speech models belonging to a first speech model network and a garbage model in a RAM, and gives a speech parameter extracted by a speech parameter extraction unit to the speech model in the RAM, and when an occurrence probability output from the garbage model is equal to or greater than a predetermined value, the matching unit loads speech models belonging to any of speech model groups in the RAM based on the occurrence probability output from the speech model belonging to the first speech model network.

    摘要翻译： 提供一种语音识别装置，其可以优选地用于减少与说话者无关的语音识别所需的存储容量。 匹配单元将属于第一语音模型网络和垃圾模型的语音模型加载到RAM中，并且将由语音参数提取单元提取的语音参数提供给RAM中的语音模型，并且当从垃圾中输出出现概率 模型等于或大于预定值，匹配单元基于从属于第一语音模型网络的语音模型输出的出现概率来加载属于RAM中的任何语音模型组的语音模型。

    Speech recognition device
    8.
    发明申请
    Speech recognition device 失效
    语音识别装置

    公开(公告)号：US20050203737A1

    公开(公告)日：2005-09-15

    申请号：US10513753

    申请日：2003-05-07

    申请人： Toshiyuki Miyazaki

    发明人： Toshiyuki Miyazaki

    IPC分类号： G10L15/08 ,  G10L15/14 ,  G10L15/18 ,  G10L15/00

    CPC分类号： G10L15/08 ,  G10L15/142 ,  G10L15/193 ,  G10L15/285

    摘要： A speech recognition device which can preferably be used for reducing the memory capacity required for speaker independent speech recognition is provided. A matching unit 114 spreads speech models belonging to a first speech model network 300 and a garbage model 350 in a RAM 112, and gives a speech parameter extracted by a speech parameter extraction unit 106 to the speech model in the RAM 112, and when an occurrence probability output from the garbage model 350 is equal to or greater than a predetermined value, the matching unit 114 spreads speech models belonging to any of speech model groups 402 in the RAM 112 based on the occurrence probability output from the speech model belonging to the first speech model network 300.

    摘要翻译： 提供了可以优选地用于减少独立于说话者的语音识别所需的存储器容量的语音识别装置。 匹配单元114将属于第一语音模型网络300和垃圾模型350的语音模型扩展到RAM 112中，并且将由语音参数提取单元106提取的语音参数提供给RAM 112中的语音模型，并且当 从垃圾模型350输出的发生概率等于或大于预定值，匹配单元114基于从属于该模式的语音模型的出现概率输出属于RAM 112中的任何一个语音模型组402的语音模型 第一语音模型网络300。

    Weight coefficient generation device, voice recognition device, navigation device, vehicle, weight coefficient generation method, and weight coefficient generation program
    10.
    发明授权
    Weight coefficient generation device, voice recognition device, navigation device, vehicle, weight coefficient generation method, and weight coefficient generation program 失效
    权重系数生成装置，语音识别装置，导航装置，车辆，权重系数生成方法以及权重系数生成程序

    公开(公告)号：US08688449B2

    公开(公告)日：2014-04-01

    申请号：US13129169

    申请日：2009-11-17

    申请人： Toshiyuki Miyazaki

    发明人： Toshiyuki Miyazaki

    IPC分类号： G10L15/10

    CPC分类号： G01C21/3608 ,  G10L2015/085

    摘要： A weight coefficient generation device, a speech recognition device, a navigation system, a vehicle, a vehicle coefficient generation method, and a weight coefficient generation program are provided for the purpose of improving a speech recognition performance of place names. In order to address the above purpose, an address database 12 has address information data items including country names, city names, street names, and house numbers, and manages the address information having a tree structure indicating hierarchical relationships between the place names from wide area to a narrow area. Each of the place names stored in the address database 12 is taken as a speech recognition candidate. A weight coefficient calculation unit 11 of a weight coefficient generation device 10 calculates a weight coefficient of the likelihood of the aforementioned recognition candidate based on the number of the street names belonging to the lower hierarchy below the city names.

    摘要翻译： 提供权重系数生成装置，语音识别装置，导航系统，车辆，车辆系数生成方法和权重系数生成程序，用于改善地名的语音识别性能。 为了解决上述目的，地址数据库12具有地址信息数据项目，包括国名，城市名，街道名称和房屋号码，并且管理具有树结构的地址信息，该结构指示来自广域的地名之间的层次关系 到一个狭窄的地区。 将存储在地址数据库12中的每个地名作为语音识别候选。 权重系数生成装置10的权重系数计算部11基于属于城市名以下的下层的街道名称的数量，计算上述识别候补的可能性的权重系数。