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公开(公告)号：US20100043882A1
公开(公告)日：2010-02-25
申请号：US12308434
申请日：2007-06-15
申请人： Setsuya Sato , Toshiyuki Yamato , Katsuaki Hayashi , Yoshitaka Matsumoto , Takahiro Ochiya , Isamu Oh
发明人： Setsuya Sato , Toshiyuki Yamato , Katsuaki Hayashi , Yoshitaka Matsumoto , Takahiro Ochiya , Isamu Oh
IPC分类号： F16L41/00
CPC分类号： C12M33/00 , B01L3/502761 , G01N15/1056 , Y10T137/0318 , Y10T137/85938
摘要： [Problems]To provide a microchip for cell arranging which transfers and arranges the cell accurately and quickly, by combining advantages of the method of an optical tweezer and of micro channel.[Means for Solving Problems]A microchip for arranging cells, including a base, the base comprising: at least one cell supply channel including a cell inlet port in liquid communication with a supply mechanism configured to supply the cells into the cell supply channel; at least one cell drain channel including a cell drain port in fluid communication with a drain mechanism, the cell drain channel configured to guide the cells to the cell drain port; at least one reservoir for temporarily storing the cells flowing between the cell supply channel and the cell drain channel; at least one cell arrangement portion for receiving cells introduced from the reservoir, the cell arrangement portion comprising plural compartments partitioned by a wall; and at least one junction channel extending from the cell arrangement portion to the reservoir; wherein the reservoir is wider than the cell supply channel, the cell drain channel and the junction channel.
摘要翻译： [问题]通过组合光镊方法和微通道的优点，提供一种用于细胞排列的微芯片，其通过精确而快速地传送和排列细胞。 解决问题的手段一种用于布置电池的微芯片，包括基座，所述基座包括：至少一个电池供应通道，包括与供配给将电池供应到电池供应通道的供电机构液体连通的电池入口; 至少一个单元排放通道，包括与漏极机构流体连通的单元排出端口，所述单元排放通道被配置为将单元引导到单元排放端口; 至少一个存储器，用于临时存储在单元供应通道和单元排放通道之间流动的单元; 至少一个用于接收从储存器引入的单元的单元布置部分，单元布置部分包括由壁分隔的多个隔室; 以及从单元布置部分延伸到储存器的至少一个接合通道; 其中所述储存器比所述电池供给通道，所述电池排出通道和所述接合通道宽。
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公开(公告)号：US20050276456A1
公开(公告)日：2005-12-15
申请号：US11139015
申请日：2005-05-26
CPC分类号： G06K9/00127 , C12M41/36 , C12M47/04 , G02B21/365
摘要： The present invention provides a cell-operating device comprising a laser light source and a microscope to observe cell sample fluorescently labeled and a camera to take the images of the cell sample that is observed with said microscope and a computer to capture the digital image data obtained by said camera and a group of mirrors comprising electronic control mirrors of which optical axis can be adjusted so that the laser light irradiated from said laser light source can be guided in to said microscope. The computer includes a binarization program for binarizing said digital image data by identifying whether each pixel of said digital image data captures a part of said cell sample according to the fluorescence luminance of each pixel. The computer has an identification program for identifying the boundaries between adjacent different values in the binarized digital image and joins the boundaries into an isolated closed curve, and a data processing program for processing said binarized digital data so that in all the area within said isolated closed curve a cell exists, and a calculation program to divide said binarized digital image data, after running said data processing program, into sections with a predefined size and identify the center of gravity coordinate of each section, and an adjustment program to adjust the optical axis of said electronic control mirrors so that said laser irradiates said center of gravity coordinate. Thus, the present invention is a cell-operating device that the laser light from said laser light source irradiates said center of gravity coordinate.
摘要翻译： 本发明提供了一种细胞操作装置，其包括激光光源和显微镜以观察荧光标记的细胞样品，以及相机拍摄用所述显微镜观察的细胞样品的图像和计算机，以捕获获得的数字图像数据 通过所述相机和一组镜子，包括可以调节光轴的电子控制反射镜，使得可以将从所述激光源照射的激光引导到所述显微镜。 计算机包括二进制化程序，用于通过识别所述数字图像数据的每个像素是否根据每个像素的荧光亮度捕获所述细胞样本的一部分来二值化所述数字图像数据。 计算机具有用于识别二进制数字图像中的相邻不同值之间的边界的识别程序，并将边界连接成隔离闭合曲线，以及用于处理所述二进制数字数据的数据处理程序，使得在所述隔离闭合的所有区域内 曲线单元存在，以及计算程序，用于在运行所述数据处理程序之后将所述二进制数字图像数据划分成具有预定尺寸的区段，并且识别每个区段的重心坐标，以及调整程序以调整光轴 的所述电子控制反射镜，使得所述激光器照射所述重心坐标。 因此，本发明是一种电池操作装置，来自所述激光光源的激光照射所述重心坐标。
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公开(公告)号：US20100066880A1
公开(公告)日：2010-03-18
申请号：US12308442
申请日：2007-06-15
CPC分类号： G01N15/1484 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0864 , B01L2400/0454 , B01L2400/0487 , C12M47/04 , G01N15/1459 , G01N15/1463 , G01N2015/149
摘要： [Problems] To provide a microchip for cell sorting to obtain the desired cell from a number of cells quickly and accurately by combining the advantages from both methods using the optical tweezer and the liquid supply to the micro channel.[Means for solving problems] A microchip for sorting at least one cell including a base, the base comprising: a cell supply channel for supplying and flowing a liquid containing cells; a cell supply channel including an inlet port in liquid communication with a supply mechanism and a drain port in liquid communication with a drain mechanism; a cell sorting channel intersecting with the cell supply channel at their middle point, the cell sorting channel including an inlet port in liquid communication with a supply mechanism and a drain port in liquid communication with a drain mechanism.
摘要翻译： [问题]提供一种用于细胞分选的微芯片，通过结合使用光学镊子的两种方法和向微通道的液体供应的优点，快速而准确地从许多细胞获得所需的细胞。 解决问题的手段一种用于对至少一个包括基底的电池进行分选的微型芯片，所述基底包括：用于供给和流动含有细胞的液体的电池供给通道; 电池供应通道，其包括与供给机构液体连通的入口和与排出机构液体连通的排出口; 细胞分选通道在其中点处与细胞供应通道相交，细胞分选通道包括与供给机构液体连通的入口和与排出机构液体连通的排出口。
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公开(公告)号：US20080057558A1
公开(公告)日：2008-03-06
申请号：US11893372
申请日：2007-08-15
申请人： Hideo Niwa , Akira Kobayashi , Setsuya Sato , Yoshitaka Matsumoto , Isamu Oh
发明人： Hideo Niwa , Akira Kobayashi , Setsuya Sato , Yoshitaka Matsumoto , Isamu Oh
CPC分类号： G02B21/365 , C12M47/04 , G02B21/0088 , G02B21/16
摘要： The present invention provides a method and an apparatus for selectively removing non-target cells from a mixed cell population of different types of cells to selectively separate target cells. Individual cells or cell groups of at least two cells from a mixed cell population of different types of cells are placed on a certain two-dimensional, coordinate system. Then a distinction is made among the individual cells or cells in the cell groups, based on the shape or size of the cells or by using a cell marker. Physical energy such as laser light is applied to the positions or regions occupied by non-target cells or cell groups including non-target cells in order to selectively kill the non-target cells or cause dysfunction of the non-target cells.
摘要翻译： 本发明提供一种用于从不同类型细胞的混合细胞群体中选择性除去非靶细胞以选择性分离靶细胞的方法和装置。 来自不同类型细胞的混合细胞群体的至少两个细胞的单个细胞或细胞群被放置在某个二维坐标系上。 然后，基于细胞的形状或大小或通过使用细胞标记，在细胞组中的各个细胞或细胞之间进行区分。 将诸如激光的物理能量施加到非靶细胞或包括非靶细胞的细胞群占据的位置或区域，以选择性地杀死非靶细胞或引起非靶细胞的功能障碍。
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公开(公告)号：US20080305537A1
公开(公告)日：2008-12-11
申请号：US11944059
申请日：2007-11-21
CPC分类号： B01L3/502761 , B01J19/0046 , B01J2219/00286 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B81B2201/0214 , B81B2201/058 , B81C1/00119
摘要： A microchip is provided with a lower substrate configured as the lower portion of the microchip, an intermediate section formed on the top of the lower substrate, and an upper substrate formed on the top of the intermediate section, wherein the lower substrate, the intermediate section, and the upper substrate are made of light-transmissive and cured resin.
摘要翻译： 微芯片设置有被配置为微芯片的下部的下基板，形成在下基板的顶部上的中间部分和形成在中间部分的顶部上的上基板，其中下基板，中间部分 ，上基板由透光固化树脂制成。
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公开(公告)号：US20120221704A1
公开(公告)日：2012-08-30
申请号：US13450376
申请日：2012-04-18
IPC分类号： G06F15/173
CPC分类号： G06F3/0637 , G06F3/0605 , G06F3/0619 , G06F3/067
摘要： Provided are a method, system, and computer storage device for managing zone information for devices in a network. A zone group table includes entries for different pairs of zones, wherein each entry indicates whether access between a pair of the zones is permitted. An attribute zone table indicates whether devices in the zones are initiator, target and/or initiator/target. For a selected zone, indication is made of whether ports in the devices in the selected zone have an initiator, target and/or initiator/target attribute as indicated in the attribute zone table. A determination is made as to whether all the ports in the devices in the selected zone have the same attribute of initiator, target or initiator/target. If so, a division proposal is indicated for the selected zone proposing to separate devices in the selected zone into at least one new zone.
摘要翻译： 提供了一种用于管理网络中的设备的区域信息的方法，系统和计算机存储设备。 区域组表包括用于不同对区对的条目，其中每个条目指示是否允许一对区域之间的访问。 属性区域表指示区域中的设备是启动器，目标和/或启动器/目标。 对于所选区域，指示所选区域中的设备中的端口是否具有属性区域表中指示的启动器，目标和/或启动器/目标属性。 确定所选区域中的设备中的所有端口是否具有与启动器，目标或启动器/目标相同的属性。 如果是，则为所选区域指示划分建议，建议将所选区域中的设备分隔成至少一个新区域。
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公开(公告)号：US20110238668A1
公开(公告)日：2011-09-29
申请号：US13049710
申请日：2011-03-16
申请人： Yoshitaka Matsumoto
发明人： Yoshitaka Matsumoto
IPC分类号： G06F17/30
CPC分类号： G06F17/30011
摘要： In a document management system that manages index item definition and document data by cabinet, an index can be easily provided. A user that can log into a first database can use an index item defined by the first database to provide an index value to document data stored in a second database.
摘要翻译： 在通过机柜管理索引项定义和文档数据的文档管理系统中，可以容易地提供索引。 可以登录到第一数据库的用户可以使用由第一数据库定义的索引项来提供索引值来记录存储在第二数据库中的数据。
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8.发明申请公开(公告)号：US20090307782A1
公开(公告)日：2009-12-10
申请号：US12476909
申请日：2009-06-02
申请人： Yoshitaka Matsumoto
发明人： Yoshitaka Matsumoto
CPC分类号： G06F21/6209
摘要： When a shortcut of a document is generated, a user is caused to set the number of times of access to the shortcut. A shortcut identifier for identifying the shortcut is generated. The shortcut identifier and the number of times of access are registered in a shortcut management table in association with each other. Thereafter, the generated shortcut identifier and a mail address as a destination of a mail are set in the shortcut. The mail attached with the shortcut is transmitted. When the mail address set in the shortcut attached to the received mail and a mail address of the user stored in a PC that receives the mail coincide with each other, access to the document linked to the shortcut is permitted. This enables to more appropriately adjust the access to the document than in the past without changing an access right of the document itself.
摘要翻译： 当生成文档的快捷方式时，使用户设置访问快捷方式的次数。 生成用于识别快捷方式的快捷方式标识符。 快捷方式标识符和访问次数相互关联地登记在快捷管理表中。 此后，将生成的快捷方式标识符和作为邮件的目的地的邮件地址设置在快捷方式中。 发送附有快捷方式的邮件。 当附加到接收到的邮件的快捷方式中设置的邮件地址和存储在接收邮件的PC中的用户的邮件地址彼此一致时，允许访问与快捷方式链接的文档。 这使得能够更适当地调整对文档的访问而不改变文档本身的访问权限。
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公开(公告)号：US20060284361A1
公开(公告)日：2006-12-21
申请号：US11455100
申请日：2006-06-19
申请人： Susumu Hashimoto , Hidetoshi Kaneko , Toshiki Ohgita , Jinichi Nagata , Yoshitaka Matsumoto , Hideo Yoshikawa , Kouzou Yamaguchi
发明人： Susumu Hashimoto , Hidetoshi Kaneko , Toshiki Ohgita , Jinichi Nagata , Yoshitaka Matsumoto , Hideo Yoshikawa , Kouzou Yamaguchi
IPC分类号： B65H5/22
CPC分类号： B65H1/00 , B65H2402/54 , B65H2405/312 , Y10T16/182
摘要： A sheet feeding device is adapted to be placed beside a sheet processing apparatus by being lifted on a side close to the sheet processing apparatus for engagement with the sheet processing apparatus. The sheet feeding device includes a housing, casters, and an elastic member. The housing stores therein sheets to be supplied to the sheet processing apparatus. Provided for supporting the housing, the casters are mounted on a bottom portion of the housing and include a first caster and a second caster. The first caster is located close to the sheet processing apparatus so as to be movable upward and downward. The second caster is located far from the sheet processing apparatus. The elastic member applies a downward force to the first caster.
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公开(公告)号：US5822001A
公开(公告)日：1998-10-13
申请号：US393455
申请日：1995-02-23
IPC分类号： G11B15/675 , G11B31/00 , G11B33/08 , G11B33/12 , H04N5/225
CPC分类号： G11B33/121 , G11B15/675 , G11B15/67581 , G11B31/006 , G11B33/08 , H04N5/2252
摘要： A cassette eject mechanism for a recording or reproducing apparatus can remove a cassette eject button from a housing and can reliably eject a tape cassette only when a tape cassette should be loaded or unloaded. A battery loading mechanism for an electronic equipment can make the loading of battery simple and reliable, and becomes easy to handle. The locking mechanism can be simplified in structure so that the number of assembly parts can considerably be reduced. Further, a mechanical chassis supporting mechanism in a recording apparatus is for use with an apparatus in which a mechanical chassis or cabinet can be reduced in thickness. According to this mechanical chassis supporting mechanism, it is possible to prevent an external stress from being applied to the mechanical chassis as a twisting deform force.
摘要翻译： 用于记录或再现装置的盒式磁带弹出机构可以从壳体移除盒式磁带弹出按钮，并且只有当磁带盒应该被装载或卸载时才能可靠地弹出磁带盒。 电子设备的电池装载机构可以使电池的负载简单可靠，变得容易处理。 可以在结构上简化锁定机构，从而可以显着地减少组装部件的数量。 此外，记录装置中的机械底盘支撑机构用于能够减小机械底盘或机柜的装置。 根据这种机械底盘支撑机构，可以防止外部应力作为扭转变形力施加到机械底盘。
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