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公开(公告)号:US20100256201A1
公开(公告)日:2010-10-07
申请号:US12721843
申请日:2010-03-11
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/4406 , A61K31/167 , A61K31/4965 , A61K31/381 , A61K31/341 , A61K31/40 , A61K31/42 , A61K31/426 , A61K31/4164 , A61K31/47 , A61K31/4355 , A61K31/444 , A61K31/445 , A61K31/495 , A61K31/27 , A61K31/439 , A61K31/17
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化的作用,因此可用于恶性肿瘤,自身免疫性疾病,皮肤病, 寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号:US20080188489A1
公开(公告)日:2008-08-07
申请号:US11984206
申请日:2007-11-14
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/4965 , A61P29/00 , A61K31/164 , A61K31/4406 , A61K31/4402
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
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公开(公告)号:US07687525B2
公开(公告)日:2010-03-30
申请号:US11984206
申请日:2007-11-14
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/44 , A61K31/16 , A61K31/50 , C07D239/42 , A61K31/40
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化作用,因此可用于恶性肿瘤,自身免疫疾病,皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号:US06174905B1
公开(公告)日:2001-01-16
申请号:US08935087
申请日:1997-09-26
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K3144
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化作用,因此可用于恶性肿瘤,自身免疫疾病,皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号:US07317028B2
公开(公告)日:2008-01-08
申请号:US10753365
申请日:2004-01-09
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/44
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化作用,因此可用于恶性肿瘤,自身免疫疾病,皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号:US06794392B1
公开(公告)日:2004-09-21
申请号:US09417216
申请日:1999-10-13
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31505
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化作用,因此可用于恶性肿瘤,自身免疫疾病,皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号:US08026239B2
公开(公告)日:2011-09-27
申请号:US12721843
申请日:2010-03-11
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/497 , A61K31/44 , A61K31/47 , A61K31/445 , C07D211/72 , C07D213/46 , C07D213/55
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: A method of treating a malignant tumor selected from the group consisting of leukemia, colorectal cancer, ovarian cancer, oral cancer, lung carcinoma, breast carcinoma, prostate carcinoma, and melanoma by administering to a patient in need thereof an effective amount of at least one compound represented by formula (1) wherein A, X, Q, R1-3, and n are defined herein.
摘要翻译: 一种治疗选自白血病,结肠直肠癌,卵巢癌,口腔癌,肺癌,乳腺癌,前列腺癌和黑素瘤的恶性肿瘤的方法,通过向有需要的患者施用有效量的至少一种 由式(1)表示的化合物,其中A,X,Q,R1-3和n如本文所定义。
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公开(公告)号:USRE40703E1
公开(公告)日:2009-04-28
申请号:US11542043
申请日:2006-10-03
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/44 , C07D211/70 , C07D211/72 , C07D211/84
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化作用,因此可用于恶性肿瘤,自身免疫疾病,皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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9.
公开(公告)号:USRE39754E1
公开(公告)日:2007-07-31
申请号:US10640278
申请日:2003-08-14
申请人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
发明人: Tsuneji Suzuki , Tomoyuki Ando , Katsutoshi Tsuchiya , Osamu Nakanishi , Akiko Saito , Takashi Yamashita , Yoshinori Shiraishi , Eishi Tanaka
IPC分类号: A61K31/44 , A01N43/08 , A01N43/32 , C07D211/70 , C07D327/04 , C07D327/06
CPC分类号: C07D213/30 , C07C233/80 , C07C237/42 , C07C255/57 , C07C271/20 , C07C275/24 , C07C275/40 , C07C335/16 , C07C335/20 , C07D207/34 , C07D211/22 , C07D213/38 , C07D213/40 , C07D213/50 , C07D213/56 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/90 , C07D241/12 , C07D241/24 , C07D249/08 , C07D261/08 , C07D261/18 , C07D263/24 , C07D275/03 , C07D277/24 , C07D277/40 , C07D295/088 , C07D307/12 , C07D307/68 , C07D333/16 , C07D333/70 , C07D401/06 , C07D405/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要: The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune diseases, dermatologic diseases and parasitism. In particular, they are highly effective as an anticancer drug, specifically to a hematologic malignancy and a solid carcinoma.
摘要翻译: 由式(1)表示的新型苯甲酰胺衍生物和本发明式(13)表示的新型酰苯胺衍生物具有诱导分化作用,因此可用于恶性肿瘤,自身免疫疾病,皮肤病的治疗或改善剂 和寄生。 特别是作为抗癌药物,特别是血液恶性肿瘤和实体癌是非常有效的。
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公开(公告)号:US07684727B2
公开(公告)日:2010-03-23
申请号:US11555296
申请日:2006-11-01
IPC分类号: G03G15/00
CPC分类号: G03G21/1685 , G03G15/2035 , G03G21/1647 , G03G2221/1639
摘要: An image recording apparatus includes a first unit, a second unit, and a fusing device for fusing and fixing a toner image on a sheet. The device has a heat roller; a pressure roller; and a contact member placed in contact with the heat roller. The first unit is movable, along a first direction, to be drawn out of the apparatus. With the first unit out of the apparatus, the second unit is movable, along a second direction perpendicular to the first direction, to be drawn out of the first unit. The device is divided into a first and a second portions where the pressure and heat rollers and the member are respectively located. The first and second portions are supported on the first and second units, respectively. The second portion is detachable from the first portion when the second unit is drawn out from the first unit.
摘要翻译: 图像记录装置包括第一单元,第二单元和用于将调色剂图像定影并固定在片材上的定影装置。 该装置具有加热辊; 压辊; 以及与所述加热辊接触地设置的接触构件。 第一单元沿着第一方向可移动以被从设备中拉出。 当第一单元离开设备时,第二单元沿着垂直于第一方向的第二方向是可移动的,以从第一单元拉出。 该装置被分成第一部分和第二部分,其中压力和热辊和部件分别位于该第一部分和第二部分。 第一和第二部分分别支撑在第一和第二单元上。 当第二单元从第一单元抽出时,第二部分可从第一部分拆卸。
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