公开(公告)号：US06295125B1

公开(公告)日：2001-09-25

申请号：US09521917

申请日：2000-03-09

申请人： Tsunemi Tokieda ,  Yukio Nogami ,  Saburo Inoue

发明人： Tsunemi Tokieda ,  Yukio Nogami ,  Saburo Inoue

IPC分类号： G01N2141

CPC分类号： G01N21/4133 ,  G01N30/74

摘要： To provide a differential refractive index detector free from fears for occurrence of personal errors in the judgement of stable condition and capable of performing highly efficient analysis operation, and a liquid chromatograph equipped with the detector. A differential refractive index detector provided with a reference cell, a sample cell, a light source for irradiating light on these two cells, a detecting part for detecting light transmitted through respective cells, and a signal processing part for applying predetermined processing to the output signal from the detecting part, which comprises means for sequentially performing an initial solution purge operation of purging the sample cell and the reference cell with an eluent by passing the eluent through the cells at the start of operation of said detector, a stabilizing solution purge operation of allowing the eluent purge of sample cell and reference cell to proceed and at the same time, confirming the stable condition thereof, and a stability confirming operation of confirming whether or not the detector has stabilized in an analysis capable condition by passing the eluent only through the sample cell, and means for announcing that the detector has stabilized in the analysis capable condition. According to the differential refractive index detector of the present invention, the processing from the initial solution purge operation to the stability confirming operation can be automated and a highly efficient analysis operation can be attained.

摘要翻译： 提供一种在稳定状态判断和能够进行高效分析操作的判断中不存在人为错误发生的差示折射率检测器和配备有检测器的液相色谱仪。 具有参考单元，样本单元，用于在这两个单元上照射光的光源的差分折射率检测器，用于检测通过各个单元传输的光的检测部分和用于对输出信号进行预定处理的信号处理部分 所述检测部分包括用于在所述检测器开始操作时通过使洗脱液通过细胞，顺序地执行用洗脱液清洗样品池和参考池的初始溶液清除操作的装置，稳定溶液清洗操作 允许样品池和参比细胞的洗脱液吹扫进行并同时确认其稳定状态，以及稳定性确认操作，通过使洗脱液仅通过该分析能力条件来确认检测器是否在分析能力条件下稳定 样品池，以及用于通知检测器在分析盖中已经稳定的装置 有条件 根据本发明的差示折射率检测器，可以自动化从初始溶液清洗操作到稳定性确认操作的处理，并且可以实现高效的分析操作。

公开(公告)号：US4794954A

公开(公告)日：1989-01-03

申请号：US22447

申请日：1987-01-13

申请人： Toshio Tokuda ,  Tsunemi Tokieda ,  Norio Ishida

发明人： Toshio Tokuda ,  Tsunemi Tokieda ,  Norio Ishida

IPC分类号： F16L55/04 ,  F16L55/05 ,  G01N30/32

CPC分类号： F16L55/05 ,  G01N30/32 ,  G01N2030/322

摘要： To prevent a pulsating flow in a column used for the liquid chromatograph, a flat liquid transferring chamber (6) provided in pressure vessels (1a, 1b) is partitioned by diaphragms (2a, 2b) on both flat sides thereof, and sealed compression chambers (5a, 5b) filled with a compressible substance are disposed facing the diaphragms.

摘要翻译： PCT No.PCT / JP86 / 00242 Sec。 371日期1987年1月13日 102（e）日期1987年1月13日PCT提交1986年5月13日PCT公布。 出版物WO86 / 06815 为了防止用于液相色谱仪的柱中的脉动流动，设置在压力容器（1a，1b）中的扁平液体传送室（6）在两个平面上被隔膜（2a，2b）分隔开 并且填充有可压缩物质的密封压缩室（5a，5b）面向隔膜设置。

公开(公告)号：US07724356B2

公开(公告)日：2010-05-25

申请号：US11913621

申请日：2006-05-11

申请人： Tsunemi Tokieda

发明人： Tsunemi Tokieda

IPC分类号： G01N21/41

CPC分类号： G01N21/4133 ,  G01N21/0303 ,  G01N21/05

摘要： The invention provides an apparatus for measuring the differential refractive index for liquid chromatography which greatly improves the sensitivity while having quick responsiveness to refractive index difference of sample liquid, as well as a differential refractive index detector and a measurement method for a differential refractive index using the same. The apparatus for measuring a differential refractive index having a flow cell deflecting a measurement beam in accordance with the refractive index difference between a reference liquid and a sample liquid for measuring the change of the deflection angle on the basis of the refractive index difference of the measurement beam transmitted between the reference liquid and the sample liquid, wherein the flow cell comprises three independent chambers including a first chamber, a second chamber adjacent to the first chamber and a third chamber adjacent to the second chamber.

摘要翻译： 本发明提供了一种用于测量液相色谱的差示折射率的装置，其极大地提高了灵敏度，同时对样品液体的折射率差异具有快速响应性，以及差示折射率检测器和使用 相同。 用于测量具有根据测量光束的折射率差值的用于测量偏转角变化的参考液体和样品液体之间的折射率差异的测量光束的流动池的测量差分折射率的装置 在所述参考液体和所述样品液体之间传输的光束，其中所述流动池包括三个独立的室，包括第一室，邻近所述第一室的第二室和与所述第二室相邻的第三室。

公开(公告)号：US20090079968A1

公开(公告)日：2009-03-26

申请号：US11913621

申请日：2006-05-11

申请人： Tsunemi Tokieda

发明人： Tsunemi Tokieda

IPC分类号： G01N21/41

CPC分类号： G01N21/4133 ,  G01N21/0303 ,  G01N21/05

摘要： The invention provides an apparatus for measuring the differential refractive index for liquid chromatography which greatly improves the sensitivity while having quick responsiveness to refractive index difference of sample liquid, as well as a differential refractive index detector and a measurement method for a differential refractive index using the same. The apparatus for measuring a differential refractive index having a flow cell deflecting a measurement beam in accordance with the refractive index difference between a reference liquid and a sample liquid for measuring the change of the deflection angle on the basis of the refractive index difference of the measurement beam transmitted between the reference liquid and the sample liquid, wherein the flow cell comprises three independent chambers including a first chamber, a second chamber adjacent to the first chamber and a third chamber adjacent to the second chamber.

摘要翻译： 本发明提供了一种用于测量液相色谱的差示折射率的装置，其极大地提高了灵敏度，同时对样品液体的折射率差异具有快速响应性，以及差示折射率检测器和使用 相同。 用于测量具有根据测量光束的折射率差值的用于测量偏转角变化的参考液体和样品液体之间的折射率差异的测量光束的流动池的测量差分折射率的装置 在所述参考液体和所述样品液体之间传输的光束，其中所述流动池包括三个独立的室，包括第一室，邻近所述第一室的第二室和与所述第二室相邻的第三室。

公开(公告)号：US5168326A

公开(公告)日：1992-12-01

申请号：US735557

申请日：1991-07-25

申请人： Tsunemi Tokieda ,  Norio Ishida

发明人： Tsunemi Tokieda ,  Norio Ishida

IPC分类号： G01J4/04 ,  G01N21/05 ,  G01N21/21 ,  G01N30/74

CPC分类号： G01J4/04 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2201/067

摘要： In a detection apparatus, a linearly polarized light beam polarized in a polarizer (62) is converted by being transmitted through a Pockels cell (60), driven by an alternative voltage, into an alternative linearly polarized light beam and a circularly polarized light beam, which is transmitted through a sample solution flowing through a flow cell (68). The transmitted light beam is separated into two polarized light components, and an intensity thereof is measured to obtain a signal proportional to an angle of rotation by the sample solution. A signal corresponding to an angle of rotation caused by an optical rotary power of the sample solution is obtained by subtracting the signal obtained during irradiation of the circularly polarized light from the signal obtained during irradiation of the linearly polarized light. The sample solution (18) is infused into an optical path of the flow cell (68) under a condition where mean velocity is 0.5 to 5 m/sec.

摘要翻译： 在检测装置中，偏振器（62）中偏振的线偏振光束通过由替代电压驱动的普克尔斯单元（60）传输到替代的线性偏振光束和圆偏振光束中而被转换， 其通过流过流动池（68）的样品溶液透过。 将透射光束分离为两个偏振光分量，并测量其强度以获得与样品溶液的旋转角成正比的信号。 通过从在线偏振光的照射期间获得的信号中减去在圆偏振光的照射期间获得的信号，获得与由样品溶液的光学旋转功率引起的旋转角度相对应的信号。 在平均速度为0.5〜5m / sec的条件下，将样品溶液（18）输入到流通池（68）的光路中。