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    Spiroketal derivatives and use thereof as diabetic medicine
    3.
    发明授权
    Spiroketal derivatives and use thereof as diabetic medicine 有权
    螺缩酮衍生物及其作为糖尿病药物的用途

    公开(公告)号：US07767651B2

    公开(公告)日：2010-08-03

    申请号：US11815074

    申请日：2006-01-27

    申请人： Takamitsu Kobayashi ,  Tsutomu Sato ,  Masahiro Nishimoto

    发明人： Takamitsu Kobayashi ,  Tsutomu Sato ,  Masahiro Nishimoto

    IPC分类号： A01N43/04 ,  C07H1/00 ,  C07H3/00 ,  C08B37/00

    CPC分类号： C07D311/96 ,  C07D491/153 ,  C07D493/10 ,  C07H19/01

    摘要： The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.

    摘要翻译： 本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 -C 14芳烷基和-C（ ΟO）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NRrf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p-或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR5-; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐，以及包含这种化合物的药物制剂或药物组合物。

    SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE
    4.
    发明申请
    SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE 有权
    SPIROKETAL衍生物及其作为糖尿病药物的用途

    公开(公告)号：US20090030006A1

    公开(公告)日：2009-01-29

    申请号：US11815074

    申请日：2006-01-27

    申请人： Takamitsu Kobayashi ,  Tsutomu Sato ,  Masahiro Nishimoto

    发明人： Takamitsu Kobayashi ,  Tsutomu Sato ,  Masahiro Nishimoto

    IPC分类号： A61K31/352 ,  A61P3/10 ,  C07D493/10 ,  A61K31/381 ,  A61K31/4433 ,  A61K31/498 ,  A61K31/404 ,  A61K31/4155 ,  C07D495/20 ,  C07D491/20

    CPC分类号： C07D311/96 ,  C07D491/153 ,  C07D493/10 ,  C07H19/01

    摘要： The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.

    摘要翻译： 本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 -C 14芳烷基和-C（ -O）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NRrf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p-或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR5-; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐，以及包含这种化合物的药物制剂或药物组合物。

    Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
    6.
    发明授权
    Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes 失效
    葡萄糖醇衍生物，其前药及其盐，以及含有糖尿病的治疗剂

    公开(公告)号：US07943748B2

    公开(公告)日：2011-05-17

    申请号：US11658765

    申请日：2005-07-27

    申请人： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Yasuhara Kato ,  Masahiro Sakaitani ,  Sang-Hak Lee

    发明人： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Yasuhara Kato ,  Masahiro Sakaitani ,  Sang-Hak Lee

    IPC分类号： C07H1/00 ,  A01N43/04 ,  A61K31/70

    CPC分类号： C07D409/10

    摘要： The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

    摘要翻译： 本发明提供了具有降低血糖水平并且具有药物所需的优选性能如持久药物活性的功能的葡糖醇衍生物; 以及用于预防或治疗高血糖疾病如糖尿病，糖尿病并发症和肥胖症的药物组合物。 该衍生物是由式（I）表示的化合物：其中m是选自1-3的整数; R1至R4各自独立地为任选取代的烷基等; Ar1是任选取代的萘基; 和A是任选取代的杂芳基，该化合物的前药或其药学上可接受的盐。 还提供了含有化合物的药物，药物组合物等。

    Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes
    7.
    发明申请
    Novel Cyclohexane Derivative, Prodrug Thereof and Salt Thereof, and Therapeutic Agent Containing the Same for Diabetes 有权
    新型环己烷衍生物，其前体药物及其盐，以及含有糖尿病的治疗剂

    公开(公告)号：US20080318874A1

    公开(公告)日：2008-12-25

    申请号：US11658400

    申请日：2005-07-26

    申请人： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Nobuo Shimma

    发明人： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Nobuo Shimma

    IPC分类号： A61K31/7028 ,  C07G3/00 ,  C07D209/04 ,  A61K31/403 ,  A61K31/05 ,  A61P3/10

    CPC分类号： C07D333/32 ,  C07C35/14 ,  C07C35/48 ,  C07C43/23 ,  C07C43/253 ,  C07C69/94 ,  C07C217/58 ,  C07C235/46 ,  C07C255/54 ,  C07C317/22 ,  C07C323/18 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/16 ,  C07D209/12 ,  C07D213/64 ,  C07D231/12 ,  C07D307/80 ,  C07D317/54 ,  C07D333/56 ,  C07H15/203 ,  C07H17/00 ,  C07H17/02

    摘要： A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, e.g., insulin dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): (wherein A is —O—, —CH2—, or —NH—; n is an integer selected between 0 and 1; R6 and R7 each independently is hydrogen or C1-6 alkyl; m is an integer selected among 1-3; Q is selected among the following formulae Q1 to Q5; Ar1 is optionally substituted arylene or optionally substituted heteroarylene, provided that the heteroarylene may be bonded to an aromatic carbocycle or aromatic heterocycle to form a fused ring; and Ar2 is optionally substituted aryl or optionally substituted heteroaryl), a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, or the like each containing the compound.

    摘要翻译： 具有降低血糖水平并且具有药物所需的优选性能的持久性药物活性，代谢稳定性和安全性的环己烷衍生物; 以及用于预防或治疗高血糖疾病（例如糖尿病，例如胰岛素依赖性糖尿病（1型糖尿病）或非胰岛素依赖性糖尿病（2型糖尿病）），糖尿病并发症和肥胖症的药物组合物 。 该衍生物是由式（I）表示的化合物：其中A是-O-，-CH2-或-NH-; n是选自0和1之间的整数; R6和R7各自独立地是氢或C1- 6烷基; m是选自1-3中的整数; Q选自下式Q1至Q5; Ar1​​是任选取代的亚芳基或任选取代的亚杂芳基，条件是杂亚芳基可以键合到芳族碳环或芳族杂环以形成 稠合环; Ar 2是任选取代的芳基或任选取代的杂芳基），化合物的前药或其药学上可接受的盐。 还提供含有化合物的药物，药物组合物等。

    Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes
    8.
    发明申请
    Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes 失效
    新型葡萄糖醇衍生物，其药物及其盐，以及含有糖尿病的治疗剂

    公开(公告)号：US20080319047A1

    公开(公告)日：2008-12-25

    申请号：US11658765

    申请日：2005-07-27

    申请人： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Yasuharu Kato ,  Masahiro Sakaitani ,  Sang-Hak Lee

    发明人： Hiroharu Matsuoka ,  Tsutomu Sato ,  Masahiro Nishimoto ,  Yasuharu Kato ,  Masahiro Sakaitani ,  Sang-Hak Lee

    IPC分类号： C07D409/10 ,  A61K31/381 ,  A61P3/10

    CPC分类号： C07D409/10

    摘要： The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

    摘要翻译： 本发明提供了具有降低血糖水平并且具有药物所需的优选性能如持久药物活性的功能的葡糖醇衍生物; 以及用于预防或治疗高血糖疾病如糖尿病，糖尿病并发症和肥胖症的药物组合物。 该衍生物是由式（I）表示的化合物：其中m是选自1-3的整数; R1至R4各自独立地为任选取代的烷基等; Ar1是任选取代的萘基; 和A是任选取代的杂芳基，该化合物的前药或其药学上可接受的盐。 还提供了含有化合物的药物，药物组合物等。

    TONER CARTRIDGE
    10.
    发明申请
    TONER CARTRIDGE 有权

    公开(公告)号：US20130034371A1

    公开(公告)日：2013-02-07

    申请号：US13650620

    申请日：2012-10-12

    申请人： Tsutomu Sato

    发明人： Tsutomu Sato

    IPC分类号： G03G15/08

    CPC分类号： G03G15/0889 ,  G03G15/0863 ,  G03G15/0865 ,  G03G15/087 ,  G03G15/0875 ,  G03G15/0877 ,  G03G21/1647 ,  G03G21/1676 ,  G03G2215/0695 ,  G03G2221/163 ,  G03G2221/1657

    摘要： A toner cartridge comprises a toner container which contains toner, a driving member which rotationally drives a conveying member, an agitating member which agitates a toner in the toner container while being rotated, a driven member which rotates in association with the driving member which is for rotationally driving the agitating member, and a rotational body which rotates according to rotation of the driven member, has a plurality of slits in rotational circumference for identifying a type of the toner cartridge, and has 1/K or more of the slits when a ratio of a rotational speed R1 (rad/s) of the driving member and a rotational speed R2 (rad/s) of the driven member is K=R2/R1.