公开(公告)号：US08207134B2

公开(公告)日：2012-06-26

申请号：US12375378

申请日：2007-07-27

申请人： Tsutomu Sato ,  Yoshihito Ohtake ,  Masahiro Nishimoto ,  Takashi Emura ,  Takamitsu Kobayashi ,  Marina Yamaguchi ,  Kyouko Takami

发明人： Tsutomu Sato ,  Yoshihito Ohtake ,  Masahiro Nishimoto ,  Takashi Emura ,  Takamitsu Kobayashi ,  Marina Yamaguchi ,  Kyouko Takami

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H1/00 ,  C07H3/00 ,  C08B37/00

CPC分类号： C07H19/01

摘要： Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(═O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供由式（I）表示的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，可被取代的C 1-6烷基，可被取代的C 7-14芳烷基 和-C（= O）Rx; n表示选自1和2的整数; 并且环Ar选自由下式（a）至（f）表示的基团。 或其前药或其药学上可接受的盐，以及药物和含有这种化合物或其前药的药物组合物或其药学上可接受的盐。

公开(公告)号：US20100234609A1

公开(公告)日：2010-09-16

申请号：US12375378

申请日：2007-07-27

申请人： Tsutomu Sato ,  Yoshihito Ohtake ,  Masahiro Nishimoto ,  Takashi Emura ,  Takamitsu Kobayashi ,  Marina Yamaguchi ,  Kyouko Takami

发明人： Tsutomu Sato ,  Yoshihito Ohtake ,  Masahiro Nishimoto ,  Takashi Emura ,  Takamitsu Kobayashi ,  Marina Yamaguchi ,  Kyouko Takami

IPC分类号： C07D493/10 ,  C07D513/20 ,  C07D498/20 ,  C07D491/20 ,  C07F7/08 ,  C07D495/20

CPC分类号： C07H19/01

摘要： Provided are a compound represented by Formula (I): wherein R1, R2, R3, and R4 are each independently selected from a hydrogen atom, a C1-6 alkyl group which may be substituted, a C7-14 aralkyl group which may be substituted and —C(═O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f). or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

摘要翻译： 提供由式（I）表示的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，可被取代的C 1-6烷基，可被取代的C 7-14芳烷基 和-C（= O）Rx; n表示选自1和2的整数; 并且环Ar选自由下式（a）至（f）表示的基团。 或其前药或其药学上可接受的盐，以及药物和含有这种化合物或其前药的药物组合物或其药学上可接受的盐。

公开(公告)号：US4770542A

公开(公告)日：1988-09-13

申请号：US872495

申请日：1986-06-10

申请人： Akio Takagi ,  Hiroyuki Higuchi ,  Yoshihito Ohtake ,  Hiroshi Matsunaka

发明人： Akio Takagi ,  Hiroyuki Higuchi ,  Yoshihito Ohtake ,  Hiroshi Matsunaka

IPC分类号： C08J3/28 ,  B29C71/04 ,  C08G18/82 ,  C08J7/18 ,  G01N17/00 ,  G01N33/44 ,  G01K17/00

CPC分类号： G01N17/004 ,  B29C71/04 ,  C08G18/82

摘要： A process and an apparatus for carrying out the process which causes acceleration of photodegradation of polymer substances. The process comprises irradiating a polymer substance with a low wavelength light and then a high wavelength light in an atmosphere with a specified humidity. The apparatus contains an irradiation lamp for irradiating a polymer substance, a rotating mounting plate for supporting the polymer substance, and humidifying means for creating a predetermined humidity for the photodegradation of the polymer substance. The photodegradation process and apparatus are used to precisely determine the useful life of polymer substances.

摘要翻译： 用于进行导致聚合物物质的光降解加速的方法和装置。 该方法包括在具有特定湿度的气氛中照射具有低波长光，然后照射高波长光的聚合物物质。 该装置包含用于照射聚合物物质的照射灯，用于支撑聚合物物质的旋转安装板，以及用于产生用于聚合物物质的光降解的预定湿度的加湿装置。 光降解过程和设备用于精确测定聚合物物质的使用寿命。

公开(公告)号：US20060063944A1

公开(公告)日：2006-03-23

申请号：US10509377

申请日：2003-04-02

申请人： Yoshiaki Nabuchi ,  Hiroshi Araya ,  Setsu Kawata ,  Kazumi Morikawa ,  Yoshitake Kanbe ,  Yoshihito Ohtake ,  Shinichi Kaiho ,  Kenji Taniguchi ,  Toshiaki Tsunenari ,  Hisashi Takasu

发明人： Yoshiaki Nabuchi ,  Hiroshi Araya ,  Setsu Kawata ,  Kazumi Morikawa ,  Yoshitake Kanbe ,  Yoshihito Ohtake ,  Shinichi Kaiho ,  Kenji Taniguchi ,  Toshiaki Tsunenari ,  Hisashi Takasu

IPC分类号： C07J53/00 ,  C07C50/18

CPC分类号： C07J1/00 ,  A61K31/566

摘要： A compound of formula (I) (where X1 and X2 represent independently a hydrogen atom or a group of formula (II) R1 represents a linear or branched halogenoalkyl group having 1-7 carbon atoms; Ra represents a hydroxyl group and Rb represents a linear or branched alkynyl group having 2-5 carbon atoms, or Ra and Rb, when taken together with the carbon to which they are bound, represent a carbonyl group; m is an integer of 2-14; n is an integer of 2-7; provided that X1 and X2 are not both a hydrogen atom), stereoisomers of the compound, or hydrates, salts or esters thereof, as well as a pharmaceutical composition containing a therapeutically effective amount of the compound.

摘要翻译： 式（I）化合物