公开(公告)号：US5478575A

公开(公告)日：1995-12-26

申请号：US37383

申请日：1993-03-26

申请人： Tsuyoshi Miyazaki ,  Yoshishige Murata ,  Daijiro Shiino ,  Kazunori Waki ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Yoshiyuki Koyama ,  Masayuki Yokoyama ,  Shigeru Kitano

发明人： Tsuyoshi Miyazaki ,  Yoshishige Murata ,  Daijiro Shiino ,  Kazunori Waki ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka ,  Yoshiyuki Koyama ,  Masayuki Yokoyama ,  Shigeru Kitano

IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K47/36 ,  A61K47/48 ,  A61K38/28

CPC分类号： A61K9/0019 ,  A61K47/32 ,  A61K47/36 ,  A61K47/48176 ,  A61K47/4823 ,  Y10S514/866

摘要： The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

摘要翻译： 本发明提供了在聚合物中具有硼酸基团的糖响应型聚合物复合物。 药物可以包含或连接，优选地，药物具有羟基。 具有硼酸基团的聚合物和具有羟基的药物可以通过硼酸酯键连接。 络合物还可以包含具有硼酸基团的聚合物和具有羟基的聚合物，并且这些聚合物可以是交联的。

公开(公告)号：US5130126A

公开(公告)日：1992-07-14

申请号：US676384

申请日：1991-03-28

申请人： Yoshiyuki Koyama ,  Shuji Kojima ,  Tsuyoshi Miyazaki ,  Akinori Suginaka ,  Takeo Matsumoto ,  Yoshishige Murata

发明人： Yoshiyuki Koyama ,  Shuji Kojima ,  Tsuyoshi Miyazaki ,  Akinori Suginaka ,  Takeo Matsumoto ,  Yoshishige Murata

IPC分类号： A61K31/557 ,  A61K47/48

CPC分类号： A61K47/48215 ,  A61K31/557 ,  Y10S514/925

摘要： The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

摘要翻译： 本发明提供了具有消化器官方向特性的聚合物组合药物，其中包含与具有亚烷基氧基作为重复单元的聚合物组合的药物。 通过使具有一个或多个末端官能团的聚氧亚烷基二醇和药物（如果需要在溶剂中）和必要时在催化剂存在下反应来制备聚合物组合药物。 能够口服给药或静脉注射，以保持血液中的浓度长时间稳定，并直接吸收或摄入消化器官如肠胃。

公开(公告)号：US5463066A

公开(公告)日：1995-10-31

申请号：US349368

申请日：1994-12-05

申请人： Tsuyoshi Miyazaki ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

发明人： Tsuyoshi Miyazaki ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

IPC分类号： A61K9/127 ,  A61K47/48 ,  C07D233/64 ,  C07F9/6506 ,  C08G65/332 ,  C08G65/335

CPC分类号： C08G65/3328 ,  A61K47/48238 ,  A61K47/48815 ,  A61K9/1271 ,  C07F9/65061 ,  C08G65/335

摘要： A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.

摘要翻译： 用于反应性泡囊形成剂的新型有用的磷脂衍生物，其由以下通式（1）表示：各自为脂族酰基，R 3表示氢原子或甲基，OA表示氧化烯基 2-4个碳原子，n表示加成的氧化烯基的平均加成摩尔数，为1-1000，p为0或1，X为4或1〜4，M为氢原子或碱金属原子 。

公开(公告)号：US5540935A

公开(公告)日：1996-07-30

申请号：US349362

申请日：1994-12-05

申请人： Tsuyoshi Miyazaki ,  Kazuo Maruyama ,  Motoharu Iwatsuru ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

发明人： Tsuyoshi Miyazaki ,  Kazuo Maruyama ,  Motoharu Iwatsuru ,  Kouzoh Sanchika ,  Mitsuhiro Nishida ,  Tohru Yasukohchi ,  Shigeru Kitano ,  Akinori Suginaka ,  Yoshihito Kadoma

IPC分类号： A61K9/127 ,  A61K47/48 ,  C07F9/6506 ,  C08G65/332 ,  C08G65/335

CPC分类号： A61K9/1271 ,  A61K47/48823 ,  C07F9/65061 ,  C08G65/3328 ,  C08G65/335 ,  Y10T428/2984

摘要： A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

摘要翻译： 1.一种活性囊泡，其特征在于，作为泡囊形成成分，含有由以下通式（1）表示的反应性磷脂衍生物和通过使所述活性囊泡与功能性物质反应制备的功能性物质固定的囊泡： 其中R1C（= O）和R2C（= O）各自表示脂族酰基，R3表示氢原子或甲基，OA表示2-4个碳原子的氧化烯基，n表示加入的氧化烯基团的平均摩尔数 并且为1-1,000，p为0或1，X表示，其中q和r各自为0至4或1至4的整数，M表示氢原子或烷基金属原子。

公开(公告)号：US08674713B2

公开(公告)日：2014-03-18

申请号：US13236562

申请日：2011-09-19

申请人： Tsuyoshi Miyazaki

发明人： Tsuyoshi Miyazaki

IPC分类号： G01R1/00 ,  G01R13/22

CPC分类号： G01R13/02 ,  G01R13/029 ,  G01R31/42

摘要： An apparatus and method corrects for zero ampere level current fluctuations in a current signal. First and second acquisition circuitry generate respective current and voltage data samples of the current signal. Current fluctuation data samples representative of zero ampere level deviations of the current signal are extracted corresponding to Off-periods of the current signal. The current fluctuation data samples of the Off-periods are interpolated to generate current fluctuation data samples representative of zero ampere level deviations of the On-periods of the current signal. The Off-period and On-period current fluctuation data samples are subtracted from the current data samples of the current signal to generate corrected zero ampere level current data samples.

摘要翻译： 一种装置和方法可校正电流信号中的零安培电平电流波动。 第一和第二采集电路产生电流信号的相应电流和电压数据采样。 对应于当前信号的关闭周期，提取表示当前信号的零安培电平偏差的电流变动数据样本。 内插关闭周期的当前波动数据样本，以产生表示当前信号的导通周期的零安培电平偏差的电流波动数据采样。 从当前信号的当前数据样本中减去关闭周期和导通周期电流波动数据样本，以产生校正的零安培电平电流数据样本。

公开(公告)号：US5594090A

公开(公告)日：1997-01-14

申请号：US416341

申请日：1995-04-04

申请人： Tsuyoshi Miyazaki ,  Hiromitsu Nakajima ,  Shuji Ichikawa ,  Yasumi Koinuma ,  Kazuo Matsuyama ,  Koji Kamenosono ,  Yoshihiro Minoshima

发明人： Tsuyoshi Miyazaki ,  Hiromitsu Nakajima ,  Shuji Ichikawa ,  Yasumi Koinuma ,  Kazuo Matsuyama ,  Koji Kamenosono ,  Yoshihiro Minoshima

IPC分类号： C08G75/04 ,  G02B1/04 ,  C08G12/20

CPC分类号： C08G75/04 ,  G02B1/041

摘要： A first prepolymer contains a structural unit represented by the formula ##STR1## where m denotes a positive number of from 2 to 20 with a polymerization degree of 2 to 1000. A second prepolymer contains a structural unit represented by the formula ##STR2## where X denotes a hydrogen atom or a halogen atom, m.sup.1 and m.sup.2 denote positive numbers of from 2 to 20 and n.sup.1 +n.sup.2 denote positive numbers of from 2 to 1000, with n.sup.1 and n.sup.2 being not equal to 0, the prepolymer having a polymerization degree of 2 to 1000. An optical material with a high refractive index is obtained by polymerizing and curing a polymerizable composition containing the first or second prepolymer.

摘要翻译： 第一预聚物含有由式“IMAGE”表示的结构单元，其中m表示2至20的正数，聚合度为2至1000.第二预聚物含有由下式表示的结构单元，其中X 表示氢原子或卤原子，m1和m2表示2〜20的正数，n1 + n2表示2〜1000的正数，n1和n2不等于0，预聚物的聚合度为 通过聚合和固化含有第一或第二预聚物的可聚合组合物，获得具有高折射率的光学材料。

公开(公告)号：US4788692A

公开(公告)日：1988-11-29

申请号：US876455

申请日：1986-06-20

申请人： Tomoyoshi Takebayashi ,  Kaoru Yamamoto ,  Tsuyoshi Miyazaki ,  Kazuo Murano ,  Hiromi Mori

发明人： Tomoyoshi Takebayashi ,  Kaoru Yamamoto ,  Tsuyoshi Miyazaki ,  Kazuo Murano ,  Hiromi Mori

IPC分类号： H04B14/06

CPC分类号： H04B14/068

摘要： An adaptive differential pulse code modulation system includes an adaptive quantizer and an adaptive predictor which have a coding characteristic optimized to a voice signal, and a quantizer and a predictor which have a coding characteristic optimized to a voice band MODEM signal. This system is normally used as a coding system optimized to the voice signal, and when this system detects a MODEM training signal, it becomes a coding system optimized to the MODEM signal.

摘要翻译： 自适应差分脉码调制系统包括具有针对语音信号优化的编码特性的自适应量化器和自适应预测器，以及具有针对语音频带MODEM信号优化的编码特性的量化器和预测器。 该系统通常用作针对语音信号优化的编码系统，当该系统检测到MODEM训练信号时，它成为针对MODEM信号优化的编码系统。

公开(公告)号：US20120098556A1

公开(公告)日：2012-04-26

申请号：US13236562

申请日：2011-09-19

申请人： Tsuyoshi Miyazaki

发明人： Tsuyoshi Miyazaki

IPC分类号： G01R31/00

CPC分类号： G01R13/02 ,  G01R13/029 ,  G01R31/42

摘要： An apparatus and method corrects for zero ampere level current fluctuations in a current signal. First and second acquisition circuitry generate respective current and voltage data samples of the current signal. Current fluctuation data samples representative of zero ampere level deviations of the current signal are extracted corresponding to Off-periods of the current signal. The current fluctuation data samples of the Off-periods are interpolated to generate current fluctuation data samples representative of zero ampere level deviations of the On-periods of the current signal. The Off-period and On-period current fluctuation data samples are subtracted from the current data samples of the current signal to generate corrected zero ampere level current data samples.

摘要翻译： 一种装置和方法可校正电流信号中的零安培电平电流波动。 第一和第二采集电路产生电流信号的相应电流和电压数据采样。 对应于当前信号的关闭周期，提取表示当前信号的零安培电平偏差的电流变动数据样本。 内插关闭周期的当前波动数据样本，以产生表示当前信号的导通周期的零安培电平偏差的电流波动数据采样。 从当前信号的当前数据样本中减去关闭周期和导通周期电流波动数据样本，以产生校正的零安培电平电流数据样本。