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    Low polydispersity poly-hema compositions
    2.
    发明授权
    Low polydispersity poly-hema compositions 有权
    低多分散性聚阴离子组成

    公开(公告)号：US07256246B2

    公开(公告)日：2007-08-14

    申请号：US10983851

    申请日：2004-11-08

    申请人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sørensen ,  Frederik Resen Steenstrup ,  Hèlène Rossignol ,  Frank F. Molock

    发明人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sørensen ,  Frederik Resen Steenstrup ,  Hèlène Rossignol ,  Frank F. Molock

    IPC分类号： C08F22/20 ,  C08F20/26

    CPC分类号： C08F20/28 ,  C08F220/06 ,  C08F220/18 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

    摘要： The present invention relates to compositions comprising poly-HEMA having a peak molecular weight between about 25,000 and about 100,000 , preferably between 25,000 and 80,000 and a polydispersity of less than about 2 to less than about 3.8 respectively and covalently bonded thereon, at least one cross-linkable functional group. The present invention further relates to low polydispersity poly-HEMA suitable for making the crosslinkable prepolymers, processes for functionalizing and purifying said poly-HEMA to form said crosslinkable prepolymers, viscous solutions made from said crosslinkable prepolymers, hydrogels made from said viscous solutions and articles made from said crosslinkable polymers, hydrogels and viscous solutions.

    摘要翻译： 本发明涉及包含聚合HEMA的组合物，其具有分子量约25,000至约100,000，优选25,000至80,000，多分散度分别小于约2至小于约3.8并且共价键合在其上，至少一个交叉 可链接的功能组。 本发明还涉及适用于制备可交联预聚物的低分散性聚HEMA，用于官能化和纯化所述聚HEMA以形成所述可交联预聚物的方法，由所述可交联预聚物制成的粘性溶液，由所述粘性溶液制成的水凝胶和制品 来自所述可交联聚合物，水凝胶和粘稠溶液。

    Low polydispersity poly-HEMA compositions
    3.
    发明授权
    Low polydispersity poly-HEMA compositions 有权
    低分散多聚HEMA组合物

    公开(公告)号：US07816460B2

    公开(公告)日：2010-10-19

    申请号：US11774453

    申请日：2007-07-06

    申请人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Resen Steenstrup ,  Helene Rossignol ,  Frank F. Molock

    发明人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Resen Steenstrup ,  Helene Rossignol ,  Frank F. Molock

    IPC分类号： C08F22/20 ,  C08F8/12

    CPC分类号： C08F20/28 ,  C08F220/06 ,  C08F220/18 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

    摘要： The present invention relates to compositions comprising poly-HEMA having a peak molecular weight between about 25,000 and about 100,000, preferably between 25,000 and 80,000 and a polydispersity of less than about 2 to less than about 3.8 respectively and covalently bonded thereon, at least one cross-linkable functional group. The present invention further relates to low polydispersity poly-HEMA suitable for making the crosslinkable prepolymers, processes for functionalizing and purifying said poly-HEMA to form said crosslinkable prepolymers, viscous solutions made from said crosslinkable prepolymers, hydrogels made from said viscous solutions and articles made from said crosslinkable polymers, hydrogels and viscous solutions.

    摘要翻译： 本发明涉及包含聚合HEMA的组合物，其具有分子量约25,000至约100,000，优选25,000至80,000，多分散度分别小于约2至小于约3.8并且共价键合在其上，至少一个交叉 可链接的功能组。 本发明还涉及适用于制备可交联预聚物的低分散性聚HEMA，用于官能化和纯化所述聚HEMA以形成所述可交联预聚物的方法，由所述可交联预聚物制成的粘性溶液，由所述粘性溶液制成的水凝胶和制品 来自所述可交联聚合物，水凝胶和粘稠溶液。

    LOW POLYDISPERSITY POLY-HEMA COMPOSITIONS
    7.
    发明申请
    LOW POLYDISPERSITY POLY-HEMA COMPOSITIONS 有权
    低聚物聚合物组合物

    公开(公告)号：US20080015322A1

    公开(公告)日：2008-01-17

    申请号：US11774453

    申请日：2007-07-06

    申请人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Steenstrup ,  Helene Rossignol ,  Frank Molock

    发明人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Steenstrup ,  Helene Rossignol ,  Frank Molock

    IPC分类号： C08F22/26

    CPC分类号： C08F20/28 ,  C08F220/06 ,  C08F220/18 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

    摘要： The present invention relates to compositions comprising poly-HEMA having a peak molecular weight between about 25,000 and about 100,000, preferably between 25,000 and 80,000 and a polydispersity of less than about 2 to less than about 3.8 respectively and covalently bonded thereon, at least one cross-linkable functional group. The present invention further relates to low polydispersity poly-HEMA suitable for making the crosslinkable prepolymers, processes for functionalizing and purifying said poly-HEMA to form said crosslinkable prepolymers, viscous solutions made from said crosslinkable prepolymers, hydrogels made from said viscous solutions and articles made from said crosslinkable polymers, hydrogels and viscous solutions.

    摘要翻译： 本发明涉及包含聚合HEMA的组合物，其具有分子量约25,000至约100,000，优选25,000至80,000，多分散度分别小于约2至小于约3.8并且共价键合在其上，至少一个交叉 可链接的功能组。 本发明还涉及适用于制备可交联预聚物的低分散性聚HEMA，用于官能化和纯化所述聚HEMA以形成所述可交联预聚物的方法，由所述可交联预聚物制成的粘性溶液，由所述粘性溶液制成的水凝胶和制品 来自所述可交联聚合物，水凝胶和粘稠溶液。

    Method and a device for preparing a mixture of a solid and a liquid component
    8.
    发明授权
    Method and a device for preparing a mixture of a solid and a liquid component 失效
    用于制备固体和液体组分的混合物的方法和装置

    公开(公告)号：US5114240A

    公开(公告)日：1992-05-19

    申请号：US521733

    申请日：1990-05-10

    申请人： Ture Kindt-Larsen ,  Per Wolff ,  Michael Morris

    发明人： Ture Kindt-Larsen ,  Per Wolff ,  Michael Morris

    IPC分类号： B01F3/12 ,  A61B50/00 ,  A61B90/00 ,  A61C5/06 ,  A61F2/00 ,  A61F2/46 ,  B01F3/00 ,  B01F5/06 ,  B01F13/00 ,  B01F15/02

    CPC分类号： B01F15/0205 ,  A61B17/8816 ,  A61B17/8825 ,  A61B17/8827 ,  A61C5/064 ,  A61C5/066 ,  B01F13/002 ,  B01F15/0212 ,  B01F15/0224 ,  B01F15/0278 ,  A61B2017/8838 ,  A61B2050/0066 ,  A61B2090/037 ,  A61F2250/0071 ,  B01F15/0266 ,  B01F2003/1257 ,  B01F2215/0029

    摘要： A mixing device comprises a first cylinder (10) containing a particulate or powdered component (11) and having a closed first end (13, 14) and an opposite second end which is closed by a piston-like venting and filtering assembly (12, 15). The device also comprises a second cylinder (18) containing the liquid component (19) and having a closed end (20, 22) and an opposite open end sealingly receiving the closed end of the first cylinder (10) therein in a piston-like manner. Means (14) are provided for communicating between the inner space of the first and second cylinders (10, 18) through the closed end (13, 14) of the first cylinder (10), when the first cylinder is forced into the second cylinder, whereby liquid from the first cylinder is injected into interstices defined between the particulate component contained in the first cylinder for providing a paste-like material. The communicating means is preferably formed by a breakable membrane (14). The venting and filtering assembly (12, 15) may be used as a piston for discharging the paste-like mixture made from the first cylinder (10). The mixing device is preferably used for mixing components so as to form a bone cement.

    摘要翻译： 混合装置包括含有颗粒或粉末状组分（11）并具有封闭的第一端（13,14）的第一气缸（10）和由活塞式排气和过滤组件（12）闭合的相对的第二端， 15）。 该装置还包括容纳液体部件（19）并具有封闭端（20,22）的第二气缸（18），相对的开口端密封地以活塞状密封地容纳第一气缸（10）的封闭端 方式。 提供装置（14），当第一气缸被迫进入第二气缸时，通过第一气缸（10）的封闭端（13,14）将第一和第二气缸（10,18）的内部空间连通， 从而将来自第一气缸的液体注入到包含在第一气缸中的颗粒组分之间限定的间隙中，以提供糊状材料。 连通装置优选由可破坏的膜（14）形成。 排气和过滤组件（12,15）可以用作用于排出由第一气缸（10）制成的糊状混合物的活塞。 混合装置优选用于混合组分以形成骨粘固剂。

    Low polydispersity poly-hema compositions
    9.
    发明申请
    Low polydispersity poly-hema compositions 有权
    低多分散性聚阴离子组成

    公开(公告)号：US20060036052A1

    公开(公告)日：2006-02-16

    申请号：US10983851

    申请日：2004-11-08

    申请人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Steensrup ,  Helene Rossignol ,  Frank Molock

    发明人： Ture Kindt-Larsen ,  Per Wolff ,  Jens-Erik Sorensen ,  Frederik Steensrup ,  Helene Rossignol ,  Frank Molock

    IPC分类号： C08F220/26 ,  C08F118/00

    CPC分类号： C08F20/28 ,  C08F220/06 ,  C08F220/18 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

    摘要： The present invention relates to compositions comprising poly-HEMA having a peak molecular weight between about 25,000 and about 100,000, preferably between 25,000 and 80,000 and a polydispersity of less than about 2 to less than about 3.8 respectively and covalently bonded thereon, at least one cross-linkable functional group. The present invention further relates to low polydispersity poly-HEMA suitable for making the crosslinkable prepolymers, processes for functionalizing and purifying said poly-HEMA to form said crosslinkable prepolymers, viscous solutions made from said crosslinkable prepolymers, hydrogels made from said viscous solutions and articles made from said crosslinkable polymers, hydrogels and viscous solutions.

    摘要翻译： 本发明涉及包含聚合HEMA的组合物，其具有分子量约25,000至约100,000，优选25,000至80,000，多分散度分别小于约2至小于约3.8并且共价键合在其上，至少一个交叉 可链接的功能组。 本发明还涉及适用于制备可交联预聚物的低分散性聚HEMA，用于官能化和纯化所述聚HEMA以形成所述可交联预聚物的方法，由所述可交联预聚物制成的粘性溶液，由所述粘性溶液制成的水凝胶和制品 来自所述可交联聚合物，水凝胶和粘稠溶液。