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公开(公告)号:US07276249B2
公开(公告)日:2007-10-02
申请号:US10444066
申请日:2003-05-23
申请人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译: 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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公开(公告)号:US07927627B2
公开(公告)日:2011-04-19
申请号:US11802542
申请日:2007-05-23
申请人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
IPC分类号: A61K9/14 , A61K31/235 , A61K9/50 , A61P3/04 , A61P43/00 , A61P9/00 , C07C69/767 , C13K13/00
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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公开(公告)号:US07931917B2
公开(公告)日:2011-04-26
申请号:US11802567
申请日:2007-05-23
申请人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
IPC分类号: A61K9/14 , A61K31/216
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译: 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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4.
公开(公告)号:US07320802B2
公开(公告)日:2008-01-22
申请号:US10692855
申请日:2003-10-27
申请人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译: 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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公开(公告)号:US20080138424A1
公开(公告)日:2008-06-12
申请号:US11979230
申请日:2007-10-31
申请人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
发明人: Tuula Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins
IPC分类号: A61K9/14 , A61K31/216
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译: 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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公开(公告)号:US20080241070A1
公开(公告)日:2008-10-02
申请号:US12058497
申请日:2008-03-28
申请人: Tuula A. Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins , Niels P. Ryde
发明人: Tuula A. Ryde , Evan E. Gustow , Stephen B. Ruddy , Rajeev Jain , Rakesh Patel , Michael John Wilkins , Niels P. Ryde
IPC分类号: A61K49/00 , A61K31/265 , A61K9/14
CPC分类号: A61K9/0053 , A61K9/145 , A61K9/1652 , A61K31/265
摘要: Disclosed are redispersible fibrate, such as fenofibrate, dosage forms. Also disclosed are in vitro methods for evaluating the in vivo effectiveness of fibrate, such as fenofibrate, dosage forms. The methods utilize media representative of in vivo human physiological conditions.
摘要翻译: 公开了可再分散的贝特类,如非诺贝特,剂型。 还公开了用于评估贝特类的体内效力的体外方法,例如非诺贝特,剂型。 该方法利用代表体内人体生理条件的介质。
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公开(公告)号:US20070298115A1
公开(公告)日:2007-12-27
申请号:US11802542
申请日:2007-05-23
申请人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号: A61K31/235 , A61K9/50 , A61P3/04 , A61P43/00 , A61P9/00 , C07C69/767 , C13K13/00
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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公开(公告)号:US20070264348A1
公开(公告)日:2007-11-15
申请号:US11710607
申请日:2007-02-26
申请人: Tuula Ryde , Evan Gustow , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号: A61K31/19
CPC分类号: A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/19 , A61K45/06 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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公开(公告)号:US20050276974A1
公开(公告)日:2005-12-15
申请号:US10444066
申请日:2003-05-23
申请人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
摘要翻译: 本发明涉及具有改善的药代动力学特征和降低的进食/禁食变异性的贝特类组合物。 组合物的贝特类颗粒具有小于约2000nm的有效平均粒度。
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公开(公告)号:US20080095851A1
公开(公告)日:2008-04-24
申请号:US11802567
申请日:2007-05-23
申请人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
发明人: Tuula Ryde , Evan Gustow , Stephen Ruddy , Rajeev Jain , Rakesh Patel , Michael Wilkins
IPC分类号: A61K9/14 , A61K31/216 , A61P3/00
CPC分类号: A61K31/19 , A61K9/145 , A61K9/146 , A61K9/2077 , A61K31/14 , A61K31/216 , A61K45/06 , Y10T428/29 , A61K2300/00
摘要: The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.
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