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1.发明授权Reagentless analysis of biological samples by applying mathematical algorithms to smoothed spectra 有权通过应用数学算法平滑光谱对生物样品进行无谓分析公开(公告)号：US07303922B2
公开(公告)日：2007-12-04
申请号：US10829777
申请日：2004-04-22
IPC分类号： G01N21/00
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译： 用于确定至少一个参数的装置和方法， 至少一种分析物的浓度，例如， 例如生物样品的尿素，例如， 例如尿。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。
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公开(公告)号：US6087182A
公开(公告)日：2000-07-11
申请号：US141483
申请日：1998-08-27
IPC分类号： G01N21/64 , G01N21/05 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/41 , G01N21/65 , G01N33/483 , G01N33/493 , G01N21/25
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e.g, urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译： 用于确定至少一个参数的装置和方法， 至少一种分析物的浓度，例如， 例如尿素，例如尿液。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。
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公开(公告)号：US06365109B1
公开(公告)日：2002-04-02
申请号：US09407397
申请日：1999-09-28
IPC分类号： G01N110
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译： 用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得其他分析物（如尿素，肌酐，葡萄糖，酮和蛋白质）的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。
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公开(公告)号：US06773922B2
公开(公告)日：2004-08-10
申请号：US10191148
申请日：2002-07-09
IPC分类号： G01N2141
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译： 用于确定生物样品例如尿液的至少一种分析物（例如尿素）的至少一个参数例如浓度的装置和方法。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得其他分析物（如尿素，肌酐，葡萄糖，酮和蛋白质）的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。
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公开(公告)号：US06426045B1
公开(公告)日：2002-07-30
申请号：US09407716
申请日：1999-09-28
IPC分类号： G01N2141
CPC分类号： G01N21/4133 , G01N21/05 , G01N21/274 , Y10T436/144444 , Y10T436/146666 , Y10T436/147777 , Y10T436/171538 , Y10T436/200833
摘要： Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample. The invention also provides an apparatus and method for measuring the refractive index of a sample of biological fluid while making spectroscopic measurements substantially simultaneously.
摘要翻译： 用于确定至少一个参数的装置和方法， 至少一种分析物的浓度，例如， 例如生物样品的尿素，例如， 例如尿。 特别适用于本发明的装置和方法的生物样品是尿液。 通常，光谱测量可用于量化生物样品中一种或多种分析物的浓度。 为了获得某些分析物（如血红蛋白和胆红素）的浓度值，可以使用可见光吸收光谱。 为了获得尿素，肌酐，葡萄糖，酮和蛋白质等其他分析物的浓度值，可以使用红外光吸收光谱。 本发明的装置和方法利用一种或多种数学技术来提高生物样品中分析物参数的测量精度。 本发明还提供了一种用于在基本上同时进行光谱测量的同时测量生物流体样品的折射率的装置和方法。
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公开(公告)号：US08099243B2
公开(公告)日：2012-01-17
申请号：US12189358
申请日：2008-08-11
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译： 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。
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公开(公告)号：US07565250B2
公开(公告)日：2009-07-21
申请号：US10991025
申请日：2004-11-17
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译： 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。
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公开(公告)号：US08005625B2
公开(公告)日：2011-08-23
申请号：US12189368
申请日：2008-08-11
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译： 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。
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公开(公告)号：US20090047679A1
公开(公告)日：2009-02-19
申请号：US12189358
申请日：2008-08-11
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译： 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。
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公开(公告)号：US20080299583A1
公开(公告)日：2008-12-04
申请号：US12189368
申请日：2008-08-11
IPC分类号： C12Q1/68
CPC分类号： G06F19/22 , C12Q1/68 , C12Q1/6851 , C12Q1/686 , C12Q2561/113 , C12Q2545/101 , C12Q2537/165
摘要： A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.
摘要翻译： 用于确定最初存在于化学和/或生物反应中的分析物的量的方法和系统以及计算机实现的方法和系统，以使包括扩增反应的数学或图形分析的部分分析自动化。
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