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公开(公告)号：US20240082261A1
公开(公告)日：2024-03-14
申请号：US18502589
申请日：2023-11-06
Applicant: UNIVERSITY OF SOUTH FLORIDA
Inventor： Charles Lockwood , Ozlem Guzeloglu-Kayisli , Umit Ali Kayisli , Frederick Schatz
IPC: A61K31/557 , A61K31/201 , A61P15/06
CPC classification number: A61K31/557 , A61K31/201 , A61P15/06
Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm
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公开(公告)号：US11197868B2
公开(公告)日：2021-12-14
申请号：US16488494
申请日：2018-02-23
Applicant: UNIVERSITY OF SOUTH FLORIDA
Inventor： Charles Lockwood , Özlem Guzeloglu-Kayisli , Ümit Kayisli , Frederick Schatz
IPC: A61K31/5575 , A61P15/06
Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.
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公开(公告)号：US11806356B2
公开(公告)日：2023-11-07
申请号：US17479523
申请日：2021-09-20
Applicant: UNIVERSITY OF SOUTH FLORIDA
Inventor： Charles Lockwood , Ozlem Guzeloglu-Kayisli , Umit Ali Kayisli , Frederick Schatz
IPC: A61K31/557 , A61K31/201 , A61P15/06
CPC classification number: A61K31/557 , A61K31/201 , A61P15/06
Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.
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公开(公告)号：US20220088032A1
公开(公告)日：2022-03-24
申请号：US17479523
申请日：2021-09-20
Applicant: UNIVERSITY OF SOUTH FLORIDA
Inventor： Charles Lockwood , Ozlem Guzeloglu-Kayisli , Umit Ali Kayisli , Frederick Schatz
IPC: A61K31/557 , A61K31/201 , A61P15/06
Abstract: Disclosed are compositions and methods for delaying or preventing idiopathic preterm birth.
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公开(公告)号：US20220096494A1
公开(公告)日：2022-03-31
申请号：US17548915
申请日：2021-12-13
Applicant: UNIVERSITY OF SOUTH FLORIDA
Inventor： Charles Lockwood , Özlem Guzeloglu-Kayisli , Ümit Kayisli , Frederick Schatz
IPC: A61K31/5575 , A61P15/06
Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.
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公开(公告)号：US20190388433A1
公开(公告)日：2019-12-26
申请号：US16488494
申请日：2018-02-23
Applicant: UNIVERSITY OF SOUTH FLORIDA
Inventor： Charles Lockwood , Özlem Guzeloglu-Kayisli , Ümit Kayisli , Frederick Schatz
IPC: A61K31/5575 , A61P15/06
Abstract: The disclosure is directed to a method of enhancing progesterone receptor (PR) activity in a mammal, which comprises administering a composition comprising an inhibitor of FK506 binding protein 51 (FKBP51) to a mammal in need thereof, such as a pregnant human female, whereby progesterone receptor activity in the mammal is enhanced as compared to a mammal not administered the composition. The method results in an extension of the gestation period and a decreased likelihood of preterm birth and fetal growth restriction.
