公开(公告)号：US11643413B2

公开(公告)日：2023-05-09

申请号：US16604494

申请日：2018-04-27

Applicant: UNIVERZITA PALACKEHO V OLOMOUCI

Inventor： Jana Bibova ,  Vaclav Mik ,  Marek Zatloukal ,  Lucie Plihalova ,  Jiri Gruz ,  Lukas Spichal ,  Karel Dolezal ,  Miroslav Strnad

IPC: C07D473/16 ,  A61K31/505 ,  A61K31/52 ,  A61K31/22 ,  A61Q19/08 ,  A61Q19/00 ,  A61P17/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  A61P39/06 ,  A61K8/49

CPC classification number: C07D473/16 ,  A61K8/4953 ,  A61Q19/08

Abstract: The invention relates to N2,N6-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.