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    Therapeutic compositions with a cytostatic action containing isocyanuric acid derivatives and process of manufacture
    1.
    发明授权
    Therapeutic compositions with a cytostatic action containing isocyanuric acid derivatives and process of manufacture 失效
    含有异氰脲酸衍生物的细胞生长抑制作用的治疗组合物及其制造方法

    公开(公告)号：US4376120A

    公开(公告)日：1983-03-08

    申请号：US289392

    申请日：1981-08-03

    申请人： Ulrich Zeidler ,  Herbert Fischer ,  Brigitte Hase ,  Hinrich Moller ,  Hans-Christoph Wilk

    发明人： Ulrich Zeidler ,  Herbert Fischer ,  Brigitte Hase ,  Hinrich Moller ,  Hans-Christoph Wilk

    IPC分类号： C07D251/34 ,  A61K31/53

    CPC分类号： C07D251/34

    摘要： New cytostatic compounds based on isocyanuric acid derivatives having 2 or 3 epoxide group containing substituents on ring nitrogen atoms, of which at least one differs from a glycidyl, having the formula ##STR1## wherein Oxiranyl is the same or different and has the formula ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and members selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyalkyl and alkoxyalkyl and n in an integer from 1 to 8, with the proviso that if n is 1 in all oxiranyl groups, at least one of R.sub.1 or R.sub.3 is other than hydrogen, and R is a member selected from the group consisting of oxiranyl as defined above, hydrogen, alkyl, alkenyl, hydrocarbon aryl, hydrocarbon aralkyl, hydrocarbon alkaryl, cycloalkyl, and cycloalkenyl, optionally containing substituents.When R.sub.1, R.sub.2 and/or R.sub.3 denote alkyl or substituted alkyl in the oxiranyl radical, the alkyl radicals preferably have from 1 to 4 carbon atoms. The total number of carbon atoms in one oxiranyl radical should not be more than 10. The preparation of these compounds by introducing oxiranyl groups of Formula II and the radical R in known manner into the isocyanuric acid ring is also claimed.

    摘要翻译： 基于在环氮原子上具有2或3个环氧基团的取代基的异氰脲酸衍生物的新的细胞抑制化合物，其中至少一个不同于缩水甘油基，其具有式（VII），其中环氧乙烷基相同或不同，具有式IMA图 其中R 1，R 2和R 3相同或不同，并且选自氢，烷基，卤代烷基，羟基烷基和烷氧基烷基和n在1至8的整数中的成员，条件是如果在所有环氧乙烷基中n为1 基团，R 1或R 3中的至少一个不是氢，R是选自如上定义的环氧乙烷，氢，烷基，烯基，烃芳基，烃芳烷基，烃烷芳基，环烷基和环烯基的成员， 任选地含有取代基。 当R1，R2和/或R3表示环氧乙烷基中的烷基或取代的烷基时，烷基优选具有1至4个碳原子。 一个环氧乙烷基中碳原子的总数不应大于10.通过将式II的环氧乙烷基和已知方式的基团R引入到异氰脲酸环中，这些化合物的制备也被要求保护。

    Amphoteric and zwitter-ionic phosphate surfactants
    4.
    发明授权
    Amphoteric and zwitter-ionic phosphate surfactants 失效
    两性和两性离子磷酸盐表面活性剂

    公开(公告)号：US4824603A

    公开(公告)日：1989-04-25

    申请号：US115003

    申请日：1987-10-28

    申请人： Hinrich Moller ,  Ulrich Zeidler

    发明人： Hinrich Moller ,  Ulrich Zeidler

    IPC分类号： A61K8/55 ,  A61Q5/02 ,  A61Q19/10 ,  B01F17/14 ,  B01F17/18 ,  C07F9/09 ,  C07F9/40 ,  C11D1/88 ,  C11D1/62 ,  C11D1/94

    CPC分类号： C11D1/886 ,  A61K8/55 ,  A61Q19/10 ,  A61Q5/02 ,  C07F9/091

    摘要： Amphoteric and zwitter-ionic phosphate surfactants corresponding to the following formula ##STR1## (a) in which R.sup.1 is a C.sub.6 -C.sub.22 alkyl group, a group R.sup.4 (OC.sub.n H.sub.2n).sub.x --, where n=2 to 4, x=1 to 6, and R.sup.4 is a C.sub.6 -C.sub.22 alkyl group, or a group R.sup.5 --CONH(CH.sub.2).sub.m, where R.sup.5 is a C.sub.5 -C.sub.21 group and m=2 to 4; R.sup.2 is hydrogen; and R.sup.3 is a C.sub.1 -C.sub.4 alkyl group or a group --(C.sub.n H.sub.2n O).sub.x --H or --(C.sub.n H.sub.2n O).sub.x --PO.sub.3 H.sub.2, where n=2 to 4 and x=1 to 6, or(b) in which R.sup.1 is a C.sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.4 2-hydroxyalkyl group; R.sup.2 is a C.sub.6 -C.sub.22 alkyl group; and R.sup.3 is as defined above.to mixtures thereof with correspondingly substituted phosphate surfactants corresponding to formula (I), in which the --PO.sub.3 H.sub.2 group or groups are replaced by hydrogen; and to neutral and basic salts of the foregoing. The invention also relates to processes for the manufacture of the above surfactants, and to their use as skin-compatible washing-active components in body shampoos and hair shampoos.

    摘要翻译： 对应于下列式（Ⅰ）（a）的两性和两性离子型磷酸酯表面活性剂，其中R 1为C 6 -C 22烷基，R 4（OC n H 2n）x - ，其中n = 2至4，x = 1〜6，R4为C6〜C22烷基，R5〜CONH（CH2）m基，R5为C5-C21基，m = 2〜4; R2是氢; R3为C1-C4烷基或 - （CnH2nO）xH或 - （CnH2nO）x-PO3H2，其中n = 2〜4，x = 1〜6，或（b）其中R1为C1- C4烷基或C2-C42-羟烷基; R2是C6-C22烷基; 并且R 3如上所定义。 与对应于式（I）的相应取代的磷酸盐表面活性剂的混合物，其中-PO 3 H 2基团被氢取代; 以及前述的中性和碱性盐。 本发明还涉及制造上述表面活性剂的方法，以及它们在人体洗发剂和洗发剂中作为皮肤相容的洗涤活性成分的用途。

    Process for the production of oil-in-water creams
    7.
    发明授权
    Process for the production of oil-in-water creams 有权
    生产水包油霜的工艺

    公开(公告)号：US6086787A

    公开(公告)日：2000-07-11

    申请号：US233592

    申请日：1999-01-19

    申请人： Fred Schambil ,  Ulrich Zeidler ,  Soraya Shamsai ,  Thomas Foerster ,  Holger Tesmann

    发明人： Fred Schambil ,  Ulrich Zeidler ,  Soraya Shamsai ,  Thomas Foerster ,  Holger Tesmann

    IPC分类号： A61K8/30 ,  A61K8/02 ,  A61K8/06 ,  A61K8/31 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/73 ,  A61K8/92 ,  A61K9/107 ,  A61Q19/00 ,  B01F17/00 ,  B01J13/00

    CPC分类号： A61K8/062 ,  A61K8/068 ,  A61K8/342 ,  A61K8/375 ,  A61K9/1075 ,  A61Q19/00 ,  B01F17/0092 ,  Y10S514/846 ,  Y10S514/938 ,  Y10S514/943

    摘要： Process for the preparation of oil-in-water creams comprising the steps ofI forming a low-viscosity, very fine particle oil-in-water emulsion by heating the following composition to a temperature within or above its phase inversion temperature range:A) 1 part by weight of liquid oil component,B) from about 0.1 to about 0.5 parts by weight of at least one nonionic emulsifier having an HLB value of from 11 to 15,C) from about 0.1 to about 0.2 parts by weight of at least one co-emulsifier selected from saturated fatty alcohols containing 16 to 22 carbon atoms and partial esters of polyols containing 3 to 6 carbon atoms with saturated fatty acids containing 143 to 22 carbon atoms, andD) from about 1 to about 6 parts by weight of water; andII thickening the emulsion from step I to the consistency of a cream by adding thereto at least one consistency generator selected from co-emulsifiers defined in step I C) above and water-soluble polymers, wherein the thickened emulsion exhibits plastic behavior at 20.degree. C. with a yield point of at least about 5 Pascal.

    摘要翻译： 水包油乳膏的制备方法，包括以下步骤：通过将下列组合物加热到其相转变温度范围内或之上的温度，形成低粘度，极细颗粒水包油乳液：A） 1重量份液体油组分，B）约0.1至约0.5重量份的至少一种HLB值为11至15的非离子乳化剂，C）至少约0.1至约0.2重量份 一种共乳化剂，其选自含有16-22个碳原子的饱和脂肪醇和含有3-6个碳原子的多元醇与含有143至22个碳原子的饱和脂肪酸的部分酯，以及D）约1至约6重量份的 水; 和II，通过向其中加入至少一种选自上述步骤IC中定义的共乳化剂的稠度产生剂和水溶性聚合物，将乳液从步骤I增稠至奶油的稠度，其中增稠的乳液在20℃表现出塑性 屈服点至少约为5帕斯卡。

    Esters of 1,2-dihydroxyalkanes as cosmetic emulsifiers and cosmetic emulsions containing them
    8.
    发明授权
    Esters of 1,2-dihydroxyalkanes as cosmetic emulsifiers and cosmetic emulsions containing them 失效
    1,2-二羟基烷烃的酯作为化妆品乳化剂和含有它们的化妆品乳液

    公开(公告)号：US4236022A

    公开(公告)日：1980-11-25

    申请号：US972014

    申请日：1978-12-21

    申请人： Ulrich Zeidler ,  Fanny Scheuermann

    发明人： Ulrich Zeidler ,  Fanny Scheuermann

    IPC分类号： C07C69/003 ,  A61K8/06 ,  A61K8/30 ,  A61K8/31 ,  A61K8/34 ,  A61K8/37 ,  A61K8/97 ,  A61K8/98 ,  B01F17/00 ,  B01F17/34 ,  B01F17/36 ,  C07C20060101 ,  C07C69/00 ,  C07C69/02 ,  C07C69/34 ,  C07C69/38 ,  C07C69/40 ,  C07C69/52 ,  C07C69/62 ,  C07C69/66 ,  C07C69/675 ,  C07C69/70 ,  C07C69/74 ,  C07C69/76

    CPC分类号： A61K8/37 ,  A61K8/06 ,  A61Q19/00

    摘要： Mono- and dicarboxylic acid esters of 1,2-dihydroxyalkanes of the formulae ##STR1## wherein A represents a bivalent radical selected from the group consisting of alkylene having from 1 to 16 carbon atoms, hydroxyalkylene having from 1 to 8 carbon atoms and 1 to 4 hydroxys, alkenylene having from 2 to 18 carbon atoms, alkoxyalkylene having from 2 to 6 carbon atoms, phenylene, alkylphenylene having from 1 to 12 carbon atoms in the alkyl; R.sub.1 represents a member selected from the group consisting of hydrogen and alkyl having from 1 to 12 carbon atoms; R.sub.2 is alkyl having from 10 to 22 carbon atoms; and R.sub.3 represents a member selected from the group consisting of hydroxyalkyl having from 1 to 4 carbon atoms, phenylhydroxyalkyl having from 1 to 4 carbon atoms in the alkyl and haloalkyl having from 1 to 4 carbon atoms; as well as water-in-oil emulsions containing from 1% to 20% by weight of said esters, from 20% to 75% by weight of water and the remainder to 100% by weight conventional oily substances used in cosmetic emulsions.

    摘要翻译： 其中A表示选自具有1至16个碳原子的亚烷基，具有1至8个碳原子的羟基亚烷基的二价基团 和1至4个羟基，具有2至18个碳原子的亚烯基，具有2至6个碳原子的烷氧基亚烷基，亚苯基，烷基中具有1至12个碳原子的烷基亚苯基; R1表示选自氢和具有1至12个碳原子的烷基的成员; R2是具有10-22个碳原子的烷基; 并且R 3表示选自具有1至4个碳原子的羟烷基，烷基中具有1至4个碳原子的苯基羟烷基和具有1至4个碳原子的卤代烷基的成员; 以及含有1重量％至20重量％的所述酯，20重量％至75重量％的水和其余至100重量％的用于化妆品乳液中的常规油性物质的油包水乳液。

    Alkyl hydroxyalkyl phosphoric acid esters
    10.
    发明授权
    Alkyl hydroxyalkyl phosphoric acid esters 失效
    烷基羟烷基磷酸酯

    公开(公告)号：US4888437A

    公开(公告)日：1989-12-19

    申请号：US69788

    申请日：1987-07-02

    申请人： Ulrich Zeidler ,  Alfred Meffert

    发明人： Ulrich Zeidler ,  Alfred Meffert

    IPC分类号： A61K8/06 ,  A61K8/55 ,  A61Q19/00 ,  B01F17/00 ,  B01F17/14 ,  B01F17/38 ,  C07F9/09

    CPC分类号： B01F17/0064 ,  A61K8/06 ,  A61K8/062 ,  A61K8/55 ,  A61Q19/00 ,  C07F9/091

    摘要： Alkyl hydroxyalkyl orthophosphoric acid esters, particularly mixtures thereof, corresponding to the following formula ##STR1## in which R.sup.1 and R.sup.2 represent C.sub.6 -C.sub.22 alkyl groups and R.sup.3 is hydrogen, a group R.sup.1 or a group --CH.sub.2 --CH(OH)--R.sup.2. The esters are prepared by reaction of phosphorus pentoxide with fatty alcohol and reaction of the phosphoric acid partial esters formed with long-chain .alpha.-epoxides. After conversion of the compounds corresponding to formula I, in which R.sup.3 is hydrogen, into the salt form, the new alkyl hydroxyalkyl orthophosphoric acid ester mixtures are particularly suitable as emulsifiers for oil-water emulsion.

    摘要翻译： 烷基羟烷基正磷酸酯，特别是其混合物，其对应于下式（Ⅰ），其中R 1和R 2表示C 6 -C 22烷基，R 3是氢，基团R 1或基团-CH 2 -CH（OH） -R2。 酯通过五氧化二磷与脂肪醇的反应和与长链α-环氧化物形成的磷酸偏酯的反应制备。 在对应于其中R 3为氢的式I化合物转化为盐形式之后，新的烷基羟烷基正磷酸酯混合物特别适合作为油水乳液的乳化剂。