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    SCREW-IN BIPOLAR ABLATION, MAPPING AND THERAPEUTIC CATHETER
    1.
    发明申请
    SCREW-IN BIPOLAR ABLATION, MAPPING AND THERAPEUTIC CATHETER 有权

    公开(公告)号：US20220361943A1

    公开(公告)日：2022-11-17

    申请号：US17744483

    申请日：2022-05-13

    申请人： University Health Network

    发明人： Kumaraswamy Nanthakumar

    IPC分类号： A61B18/14 ,  A61B5/283 ,  A61B5/367 ,  A61B5/00

    摘要： Various embodiments are described herein for a bipolar catheter that generally comprises: a catheter body having a distal end portion and a proximal end portion; a first electrode at the distal end portion, the first electrode being on a spiral structure for rotational insertion into a physiological target region; a second electrode at the proximal end portion and spaced apart from the first electrode; and first and second electrode terminals spaced apart from one another at the proximal end portion and electrically coupled to the first and second electrodes respectively. The first and second electrodes are configured to function as active and dispersive electrodes respectively, or vice-versa. Also described are various embodiments of methods which generally include coupling the bipolar catheter to a signal generator; inserting the bipolar catheter at a physiological target region; and performing the procedure.

    INTELLIGENT VECTOR ELECTRODE FOR A PACEMAKER OR AN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR
    4.
    发明申请
    INTELLIGENT VECTOR ELECTRODE FOR A PACEMAKER OR AN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR 有权

    公开(公告)号：US20220226637A1

    公开(公告)日：2022-07-21

    申请号：US17607600

    申请日：2020-05-06

    申请人： University Health Network

    发明人： Kumaraswamy Nanthakumar

    IPC分类号： A61N1/05 ,  A61N1/365 ,  A61N1/37

    摘要： A multi-electrode implantable device for sensing cardiac signals and various methods for using the sensed cardiac signals are described herein. The multi-electrode device comprises a tetrahedral electrode cluster at a tip at a distal end of the lead/device; four electrodes embedded in the tetrahedral configuration; and four individual wires extending from the electrodes within the lead for receiving voltages sensed by the four electrodes. The methods can be used for deriving various physiological features that can be used in various ways including: diagnosing a physiological condition, efficient sensing of physiological signals, applying more efficient pacing by a pacemaker and indirect cardiac mapping. One or more of the physiological features may be used for applying appropriate treatment methods by a pacemaker/ICD or for applying cardiac ablation or cryofreezing.

    DANTROLENE AND ANALOGS THEREOF FOR THE CHRONIC TREATMENT AND PREVENTION OF DYSSYNCHRONOUS CARDIAC DYSFUNCTION
    6.
    发明申请
    DANTROLENE AND ANALOGS THEREOF FOR THE CHRONIC TREATMENT AND PREVENTION OF DYSSYNCHRONOUS CARDIAC DYSFUNCTION 审中-公开

    公开(公告)号：US20200375951A1

    公开(公告)日：2020-12-03

    申请号：US16763914

    申请日：2018-11-14

    申请人： UNIVERSITY HEALTH NETWORK

    发明人： Kumaraswamy Nanthakumar

    IPC分类号： A61K31/4178 ,  A61K31/422

    摘要： The present disclosure relates to methods for the chronic treatment of dyssynchronous cardiac dysfunction (including non-arrhythmia cardiac dysfunction such as heart failure, cardiomyopathy, viral myocarditis, ischemia induced cardiomyopathy, ischemia, chemotheraphy, pacing induced cardiomyopathy or ion channel mutation related dysfunction) and for the prevention or treatment of diseases or conditions associated with dyssynchronous cardiac dysfunction. The method comprises chronically administering to a patient an effective amount of dantrolene, or derivative or analogs thereof (such as azumolene).

    METHODS OF ADMINISTERING DANTROLENE FOR THE ACUTE TREATMENT OF CARDIAC ARRHYTHMIAS
    8.
    发明申请
    METHODS OF ADMINISTERING DANTROLENE FOR THE ACUTE TREATMENT OF CARDIAC ARRHYTHMIAS 有权
    用于治疗心脏病的急性心肌梗死的方法

    公开(公告)号：US20160101085A1

    公开(公告)日：2016-04-14

    申请号：US14889767

    申请日：2014-05-05

    申请人： University Health Network, Toronto General Hospital

    发明人： Kumaraswamy Nanthakumar

    IPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K45/06

    CPC分类号： A61K31/4178 ,  A61K31/422 ,  A61K45/06 ,  A61K2300/00

    摘要： The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.

    摘要翻译： 本说明书涉及施用有效量的抗心律失常药物（例如丹曲林，azumolene或其药学上可接受的盐）用于急性治疗心律失常的方法，例如心房颤动，室性早搏，室性心动过速或室性心律失常 原纤维化和预防随后的心律失常，其中所述方法降低发病率和死亡率。