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    Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates and method of use
    9.
    发明授权
    Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates and method of use 失效
    磷酸化糖基酰胺， - 脲， - 氨基甲酸酯和 - 硫代氨基甲酸酯及其使用方法

    公开(公告)号：US4686208A

    公开(公告)日：1987-08-11

    申请号：US673811

    申请日：1984-11-21

    申请人： Oswald Lockhoff ,  Bernd-Wieland Kruger ,  Peter Stadler ,  Arnold Paessens ,  Gert Streissle ,  Peter Taylor ,  Hans-Joachim Zeiler ,  Karl-Georg Metzger

    发明人： Oswald Lockhoff ,  Bernd-Wieland Kruger ,  Peter Stadler ,  Arnold Paessens ,  Gert Streissle ,  Peter Taylor ,  Hans-Joachim Zeiler ,  Karl-Georg Metzger

    IPC分类号： A61K31/70 ,  C07H13/06 ,  C07H13/12 ,  C07H5/06

    CPC分类号： C07H13/06 ,  C07H13/12

    摘要： Compounds of the formula ##STR1## in which R.sup.1 represents an optionally substituted, straight-chain or branched, saturated, monounsaturated or polyunsaturated alkyl radical, an optionally substituted, saturated or one- or polyunsaturated cycloalkyl radical or an optionally substituted aryl radical or aralkyl radical,X represents CH.sub.2, O, S, NH or N-alkyl with up to 20 C atoms,R.sup.2 has the meaning of R.sup.1, and can represent hydrogen if X denotes CH.sub.2, the radicals R.sup.3 independently of one another represent hydrogen, an acyl radical or alkyl radical with in each case up to 20 C atoms, a silyl radical and/or a phosphoric acid or phosphoric acid ester radical andR.sup.4 denotes hydrogen, methyl or --CH.sub.2 --OR.sup.3, with the proviso that one of the radicals R.sup.3 always represents a phosphoric acid or phosphoric acid ester radical, which stimulate a patient's immune system and are thereby effective in combating viral disease and bacterial infection.

    摘要翻译： 式“IMAGE”的化合物，其中R 1表示任选取代的直链或支链饱和的单不饱和或多不饱和烷基，任选取代的饱和或一或多不饱和环烷基或任选取代的芳基或芳烷基 X表示CH 2，O，S，NH或具有多达20个C原子的N-烷基，R 2具有R 1的含义，如果X表示CH 2，则可表示氢，基团R 3彼此独立地表示氢，酰基 或烷基，在每种情况下最多达20个C原子，甲硅烷基和/或磷酸或磷酸酯基，R4表示氢，甲基或-CH2-OR3，条件是基团R3之一总是表示 磷酸或磷酸酯基，其刺激患者的免疫系统，从而有效地对抗病毒性疾病和细菌感染。

    Penicillins
    10.
    发明授权
    Penicillins 失效
    青霉素

    公开(公告)号：US3993770A

    公开(公告)日：1976-11-23

    申请号：US629526

    申请日：1975-11-06

    申请人： Wilfried Schrock ,  Karl-Georg Metzger ,  Hans-Bodo Konig

    发明人： Wilfried Schrock ,  Karl-Georg Metzger ,  Hans-Bodo Konig

    IPC分类号： C07D231/08 ,  C07D231/20 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  C07D499/70

    CPC分类号： C07D231/08 ,  C07D231/20 ,  C07D499/00

    摘要： A compound of the formula: ##SPC1##Or a pharmaceutically acceptable nontoxic salt thereof whereinR.sub.1 is hydrogen, straight or branched chain alkyl of 1 to 5 carbon atoms, monoaralkyl of up to 8 carbon atoms, monoaryl, substituted monoaryl, or thienyl;A is a moiety of the formula: ##EQU1## wherein R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and each is hydrogen, straight or branched chain alkyl of 1 to 5 carbon atoms, monoaralkyl of up to 8 carbon atoms, monoaryl, substituted monoaryl, or thienyl;B is a moiety of the formula: ##SPC2##WhereinR.sub.8, r.sub.9 and R.sub.10 are the same or different and each is hydrogen, fluorine, chlorine, bromine, iodine, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphonyl, sulphamyl, nitro, cyano, di(lower alkyl)amino, lower alkanoylamino, lower alkanoyloxy, lower alkylsulphonylamino, trifluoromethyl or hydroxy;E is oxygen or sulphur; andC* is a carbon atom constituting a center of chirality, are useful for their antibacterial activity.

    摘要翻译： 化学式为：+ q，10或其药学上可接受的非对映盐，其中R1为氢，1至5个碳原子的直链或支链烷基，至多8个碳原子的单烷基，单芳基，取代的单芳基或噻吩基; A是下式的部分：R4R2O || PARALLEL -CCC-，|| R5R3 R3R2O || PARALLEL -CC = NC-，| R4 R6R4R2O R3R2O R2O ||| PARALLEL || PARALLEL | PARALLEL -CCCC-，-C = CC-，-C = NC-，||| R7R5R3 R5R3R2O R4R3R2O OR2O ||| PARALLEL ||| PARALLEL PARALLEL | PARALLEL -CCNC-，-C = CNC-，-CNC-，|| R6R4 OR2R3O平行角度平行+ TR 或-C-C-C-，其中R 2，R 3，R 4，R 5，R 6和R 7相同或不同，各自为氢，1至5个碳原子的直链或支链烷基，至多8个碳原子的直链烷基 原子，单芳基，取代的单芳基或噻吩基; B是下式的部分：