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公开(公告)号：US20180042758A1
公开(公告)日：2018-02-15
申请号：US15793905
申请日：2017-10-25
CPC分类号： A61F5/41 , A61F2005/418 , A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61H2205/087 , A61N1/18 , A61N1/36107 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/362 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49002
摘要： An exemplary method treating an erectile dysfunction condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a target tissue location within the patient by way of an electrode array located within the patient at an acupoint corresponding to the target tissue location.
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2.发明授权Implantable electroacupuncture system and method for treating Parkinson's disease and essential tremor 有权可植入式电针系统及治疗帕金森病及原发性震颤的方法公开(公告)号：US09433786B2
公开(公告)日：2016-09-06
申请号：US13765572
申请日：2013-02-12
CPC分类号： A61N1/36067 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3782
摘要： An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied at at least one of acupoints GB34 and GV20. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.
摘要翻译： 可植入电针装置（IEAD）通过施加在至少一个穴位GB34和GV20上施加的刺激脉冲来治疗帕金森病或基本震颤。 IEAD包括密封的可植入电针（EA）装置，其具有位于其壳体外部的至少两个电极。 外壳包含主电源，脉冲发生电路和无线感应外部生成的操作命令的传感器。 脉冲产生电路至少部分地通过通过传感器感测的操作命令来产生刺激脉冲。 刺激脉冲根据指定的刺激方案通过电极施加到指定的穴位或神经。 这种刺激方案要求在非常低的占空比不大于0.05的情况下施用刺激会话。
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3.发明授权Method for reducing hypertension using an implantable electroacupuncture device 有权使用可植入电针装置降低高血压的方法公开(公告)号：US09358382B2
公开(公告)日：2016-06-07
申请号：US14446500
申请日：2014-07-30
CPC分类号： A61N1/0504 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3605 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10S128/907
摘要： Disclosed is an implantable, coin-sized, self-contained, leadless electroacupuncture (EA) device having at least two electrode contacts attached to the surface of its housing. The electrodes include a central cathode electrode on a bottom side of the housing, and a circumferential anode electrode that surrounds the cathode electrode. In one embodiment, the anode annular electrode is a ring electrode placed around the perimeter edge of the coin-shaped housing. The EA device is adapted to be implanted through a very small incision, e.g., less than about 2-3 cm in length, directly adjacent to a selected acupuncture site known to moderate or affect a hypertension condition of a patient. Appropriate power management circuitry within the device allows a primary battery having a relatively high internal impedance to be used without causing unacceptable dips in battery voltage when the instantaneous battery current surges. Stimulation pulses are generated during a stimulation session that has a duration of T3 minutes and which is applied every T4 minutes. The duty cycle, or ratio of T3 to T4, is very low, not greater than 0.05. This low duty cycle, along with careful power management, allows the EA device to perform its intended function for several years.
摘要翻译： 公开了一种植入式，硬币大小的独立的无引线电针（EA）装置，其具有附接到其壳体表面的至少两个电极触点。 电极包括在壳体的底侧上的中央阴极电极和围绕阴极电极的周向阳极电极。 在一个实施例中，阳极环形电极是围绕硬币形壳体的周边边缘放置的环形电极。 EA装置适于通过非常小的切口植入，例如长度小于约2-3厘米，直接与已知中度或影响患者高血压状况的所选择的针灸部位相邻。 器件内的合适的电源管理电路允许使用具有相对较高的内部阻抗的一次电池，而不会在瞬间电池电流骤升时导致电池电压的不可接受的下降。 在刺激会话期间产生刺激脉冲，持续时间为T3分钟，每T4分钟应用一次。 T3到T4的占空比或比例很低，不大于0.05。 这个低占空比，以及仔细的电源管理，允许EA设备执行其预期功能几年。
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4.发明授权Implantable electroacupuncture system and method for treating dyslipidemia and obesity 有权植入式电针系统及治疗血脂异常和肥胖的方法公开(公告)号：US09314399B2
公开(公告)日：2016-04-19
申请号：US13736033
申请日：2013-01-07
CPC分类号： A61H39/002 , A61F5/0026 , A61H2201/50 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36085 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
摘要： An Implantable ElectroAcupuncture System (IEAS) treats dyslipidemia or obesity through application of stimulation pulses applied at at least one of acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, or LR8, or underlying nerves saphenous or peroneal. The IEAS includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.
摘要翻译： 可植入电针刺系统（IEAS）通过施加在穴位ST36，SP4，ST37，ST40，SP6，SP9，K16或LR8中的至少一个或隐匿性或腓神经的下面的神经施加刺激脉冲来治疗血脂异常或肥胖。 IEAS包括密封的可植入电针（EA）装置，其具有位于其壳体外部的至少两个电极。 外壳包含主电源，脉冲发生电路和无线感应外部生成的操作命令的传感器。 脉冲产生电路至少部分地通过通过传感器感测的操作命令来产生刺激脉冲。 刺激脉冲根据指定的刺激方案通过电极施加到指定的穴位或神经。 这种刺激方案要求在非常低的占空比不大于0.05的情况下施用刺激会话。
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5.发明申请Implantable Electroacupuncture System and Method for Treating Depression and Similar Mental Conditions 审中-公开植入式电针系统及治疗抑郁症及类似心理病症的方法公开(公告)号：US20160051442A1
公开(公告)日：2016-02-25
申请号：US14929253
申请日：2015-10-30
CPC分类号： A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36096 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
摘要： A method of treating a mental disorder of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at or near an acupoint corresponding to at least one of a trigeminal nerve and an occipital nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device, the stimulation sessions to at least one of the trigeminal nerve and the occipital nerve by way a central electrode and an annular electrode located on the electroacupuncture device in accordance with the duty cycle.
摘要翻译： 一种治疗患者精神障碍的方法包括：通过植入在患者的皮肤表面下方的电针装置产生，所述电针在与患者的三叉神经和枕骨神经中的至少一个相对应的穴位处或附近，刺激 以小于0.05的占空比进行会话，以及2）通过所述电针装置将位于所述电针上的中心电极和环形电极施加到所述三叉神经和所述枕骨神经中的至少一个的刺激会话 按照占空比。
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公开(公告)号：US20160008222A1
公开(公告)日：2016-01-14
申请号：US14861839
申请日：2015-09-22
IPC分类号： A61H39/00
CPC分类号： A61H39/002 , A61H2201/01 , A61H2201/5005 , A61H2201/5038 , A61N1/32 , A61N1/36085 , A61N1/36089 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49208
摘要： An exemplary method for treating obesity in a patient comprising the steps of 1) implanting a coin-sized electroacupuncture (EA) device in the patient below the patient's skin at at least one specified stimulation site, 2) enabling the EA device to generate stimulation sessions at a duty cycle that is less than 0.05, each stimulation session comprising a series of stimulation pulses, wherein the duty cycle is the ratio of T3/T4, where T3 is the duration in minutes of each stimulation session, and T4 is the time in minutes between stimulation sessions, and 3) delivering the stimulation pulses of each stimulation session to the at least one specified stimulation site through at least two electrodes/arrays attached to an outside surface of the EA device.
摘要翻译： 一种用于治疗患者肥胖症的示例性方法，包括以下步骤：1）在至少一个特定刺激部位的患者皮肤下的患者中植入硬币大小的电针（EA）装置，2）使得EA装置能够产生刺激会话 在小于0.05的占空比下，每个刺激会话包括一系列刺激脉冲，其中占空比是T3 / T4的比例，其中T3是每个刺激会话的持续时间（分钟），T4是 分钟，以及3）通过连接到EA设备的外表面的至少两个电极/阵列将每个刺激会话的刺激脉冲递送到至少一个指定的刺激部位。
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7.发明申请Methods and Systems for Treating Cardiovascular Disease Using an Implantable Electroacupuncture Device 有权使用植入式电针装置治疗心血管疾病的方法和系统公开(公告)号：US20150321006A1
公开(公告)日：2015-11-12
申请号：US14805346
申请日：2015-07-21
CPC分类号： A61H39/002 , A61H39/00 , A61H2201/01 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3782 , A61N1/3787 , Y10T29/49002
摘要： An exemplary method treating a cardiovascular disease in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a median nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the median nerve by way of the central electrode and the annular electrode in accordance with the duty cycle.
摘要翻译： 治疗患者心血管疾病的示例性方法包括：1）通过植入患者皮肤表面下方的电针，在对应于患者正中神经的穴位产生刺激，占空比小于0.05 其特征在于，所述占空比为T3〜T4的比例，所述刺激对象中包含的每个刺激对象具有T3分钟的持续时间，以T4分钟的速度发生，电针装置包括第一极性的中心电极 以及第二极性并与中心电极间隔开的环形电极; 和2）通过电针装置，根据占空比通过中心电极和环形电极将刺激会话应用于正中神经。
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8.发明申请Method for Treating Cardiovascular Disease Using Implantable Electroacupuncture Device 有权使用植入式电针装置治疗心血管疾病的方法公开(公告)号：US20150196761A1
公开(公告)日：2015-07-16
申请号：US14669155
申请日：2015-03-26
IPC分类号： A61N1/36
CPC分类号： A61H39/002 , A61H39/00 , A61H2201/01 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3782 , A61N1/3787 , Y10T29/49002
摘要： An Implantable ElectroAcupuncture Device (IEAD) treats cardiovascular disease through application of stimulation pulses applied at at least one of acupoints EX-HN1, BL14, HT7, HT5, PC6, ST36, LI11, LU7, and LU2. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
摘要翻译： 可植入电针装置（IEAD）通过施加在穴位EX-HN1，BL14，HT7，HT5，PC6，ST36，LI11，LU7和LU2中的至少一个上施加的刺激脉冲来治疗心血管疾病。 IEAD包括可植入的硬币尺寸的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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9.发明授权Implantable electroacupuncture system and method for treating cardiovascular disease 有权植入式电针系统及治疗心血管疾病的方法公开(公告)号：US08996125B2
公开(公告)日：2015-03-31
申请号：US13622653
申请日：2012-09-19
IPC分类号： A61H39/00
CPC分类号： A61H39/002 , A61H39/00 , A61H2201/01 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3782 , A61N1/3787 , Y10T29/49002
摘要： An implantable electroacupuncture device (IEAD) treats cardiovascular disease through application of stimulation pulses applied at at least one of acupoints EX-HN1, BL14, HT7, HT5, PC6, ST36, LI11, LU7 and LU2. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
摘要翻译： 可植入电针装置（IEAD）通过施加在穴位EX-HN1，BL14，HT7，HT5，PC6，ST36，LI11，LU7和LU2中的至少一个上施加的刺激脉冲来治疗心血管疾病。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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10.发明授权Stimulation paradigm to improve blood pressure dipping in an implantable electroacupuncture device 有权刺激范式，以改善植入式电针装置中浸润的血压公开(公告)号：US08942808B2
公开(公告)日：2015-01-27
申请号：US13786447
申请日：2013-03-05
CPC分类号： A61N1/36117 , A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5041 , A61H2201/5097 , A61N1/3605 , A61N1/36135 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3782
摘要： A coin-sized implantable electroacupuncture (EA) device defines a stimulation paradigm, or stimulation regimen, that controls when EA stimulation pulses are applied to a selected acupoint, or other specified tissue location, to treat hypertension or nondipping. The stimulation regimen is applied when the patient is sleeping in order to minimize or mitigate the occurrence of nondipping or reverse dipping of the patient's blood pressure. In one embodiment, medical personnel, set a timing reference marker at the time of implant that defines how much time should elapse before a nighttime stimulation window opens that allows an EA stimulation session to be applied to the patient. In another embodiment, the patient sets the time when the nighttime stimulation window opens or when the EA stimulation session begins. Typically, an EA stimulation session is applied to the patient at a low duty cycle, e.g., only once a week during the nighttime.
摘要翻译： 硬币大小的可植入电针（EA）装置定义了刺激范例或刺激方案，其控制何时将EA刺激脉冲施加到选定的穴位或其他指定的组织位置以治疗高血压或非浸润。 当患者睡觉时应用刺激方案以便最小化或减轻患者血压的非浸没或反浸渍的发生。 在一个实施例中，医务人员在植入时设置定时参考标记，其定义在夜间刺激窗口打开之前经过多少时间，其允许将EA刺激会话应用于患者。 在另一个实施例中，患者设定夜间刺激窗口打开或EA刺激会话开始时的时间。 通常，EA刺激会话以低工作周期应用于患者，例如在夜间仅每星期一次。
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