利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

22 条记录 (耗时 0.046 秒)

    Substituted Dihydroimidazoles and their Use in the Treatment of Tumors
    3.
    发明申请
    Substituted Dihydroimidazoles and their Use in the Treatment of Tumors 审中-公开
    取代的二氢咪唑及其在肿瘤治疗中的应用

    公开(公告)号：US20100075966A1

    公开(公告)日：2010-03-25

    申请号：US12516414

    申请日：2007-11-26

    申请人： Sylvie Chamoin ,  Hans- Jorg Roth ,  Juerg Zimmermann ,  Thomas Zoller

    发明人： Sylvie Chamoin ,  Hans- Jorg Roth ,  Juerg Zimmermann ,  Thomas Zoller

    IPC分类号： A61K31/5377 ,  C07D233/54 ,  A61K31/4164 ,  C07D403/02 ,  A61K31/496 ,  C07D413/14 ,  C07D413/02 ,  C07D401/02 ,  A61K31/4439 ,  A61P35/00

    CPC分类号： C07D233/40 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12

    摘要： The invention relates to dihydroimidazoles of formula rac-(I), wherein the radicals and symbols are as defined herein; their use as inhibitors of the interaction of the MDM2 protein with a p53-like peptide, new pharmaceutical formulations comprising said compounds, said compounds for use in the therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of proliferative diseases or for the manufacture of pharmaceutical formulations useful in the treatment of proliferative diseases that respond to modulation of the interaction of the MDM2 protein with a p53-like peptide, a pharmaceutical formulation e.g. useful in the treatment of proliferative diseases that respond to modulation of the interaction of the MDM2 protein with a p53-like peptide comprising said compound, methods of treatment comprising administration of said compounds to a warm-blooded animal, and/or processes for the manufacture of said compounds.

    摘要翻译： 本发明涉及式rac-（I）的二氢咪唑，其中基团和符号如本文所定义; 它们作为MDM2蛋白与p53样肽的相互作用的抑制剂的用途，包含所述化合物的新药物制剂，用于治疗温血动物，特别是人类的所述化合物，其用于治疗增殖性疾病 或用于制造用于治疗对MDM2蛋白与p53样肽的相互作用的调节作出反应的增殖性疾病的药物制剂，药物制剂例如 可用于治疗对MDM2蛋白与包含所述化合物的p53样肽的相互作用的调节作用的增殖性疾病的治疗，所述方法包括向温血动物施用所述化合物和/或制备方法 的所述化合物。