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公开(公告)号:US20130331397A1
公开(公告)日:2013-12-12
申请号:US14000578
申请日:2012-02-23
申请人: Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
发明人: Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号: C07D471/04 , C07D207/09
CPC分类号: C07D471/04 , C07D207/09
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. wherein: A is X1 is CH or N;
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。 其中:A是X 1是CH或N;
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公开(公告)号:US20120065184A1
公开(公告)日:2012-03-15
申请号:US13227957
申请日:2011-09-08
申请人: Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
发明人: Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号: A61K31/5025 , A61K31/5377 , A61P11/06 , A61P25/00 , A61P17/00 , C07D487/04 , A61P35/00
CPC分类号: C07D471/04 , C07D487/04
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。
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公开(公告)号:US09102671B2
公开(公告)日:2015-08-11
申请号:US14000578
申请日:2012-02-23
申请人: Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
发明人: Valentina Molteni , Yi Fan , Jon Loren , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号: A61K31/497 , C07D471/04 , C07D207/09
CPC分类号: C07D471/04 , C07D207/09
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. wherein: A is X1 is CH or N;
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。 其中:A是X 1是CH或N;
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公开(公告)号:US08637516B2
公开(公告)日:2014-01-28
申请号:US13227957
申请日:2011-09-08
申请人: Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
发明人: Yi Fan , Jon Loren , Valentina Molteni , Pamela A. Albaugh , Gregory Chopiuk , Jeffrey M. Smith , Brenton T. Flatt
IPC分类号: A01N43/58 , A61K31/50 , C07D487/00
CPC分类号: C07D471/04 , C07D487/04
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TRK激酶活性相关的疾病或病症的方法。
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公开(公告)号:USD706524S1
公开(公告)日:2014-06-10
申请号:US29432343
申请日:2012-09-14
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公开(公告)号:USD680727S1
公开(公告)日:2013-04-30
申请号:US29432353
申请日:2012-09-14
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公开(公告)号:US09482617B2
公开(公告)日:2016-11-01
申请号:US13913333
申请日:2013-06-07
CPC分类号: G01N21/6486 , G01S7/4802 , G01S7/4876 , G01S17/02 , G01S17/026 , G01S17/107 , G01S17/89
摘要: A method comprising: providing a device for detecting a biological signature behind a glass surface using non-visible light is provided. A method of emitting one or more pulses of energy at a specific wavelength over a field of illumination towards a target area, filtering out one or more returning wavelengths from the target area, and determining, based on the filtering, if a combination of a fluorescence wavelength and a source wavelength is present, is also provided. An associated system is further provided.
摘要翻译: 一种方法,其特征在于,提供一种用于使用不可见光来检测玻璃表面后面的生物学特征的装置。 一种将朝向目标区域的照明场上的特定波长的一个或多个能量脉冲发射到目标区域的方法,从目标区域滤出一个或多个返回波长,以及基于滤波来确定是否结合荧光 还提供了波长和源波长。 还提供了相关联的系统。
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8.
公开(公告)号:US20150253253A1
公开(公告)日:2015-09-10
申请号:US13913333
申请日:2013-06-07
CPC分类号: G01N21/6486 , G01S7/4802 , G01S7/4876 , G01S17/02 , G01S17/026 , G01S17/107 , G01S17/89
摘要: A method comprising: providing a device for detecting a biological signature behind a glass surface using non-visible light is provided. A method of emitting one or more pulses of energy at a specific wavelength over a field of illumination towards a target area, filtering out one or more returning wavelengths from the target area, and determining, based on the filtering, if a combination of a fluorescence wavelength and a source wavelength is present, is also provided. An associated system is further provided.
摘要翻译: 一种方法,其特征在于,提供一种用于使用不可见光来检测玻璃表面后面的生物学特征的装置。 一种将朝向目标区域的照明场上的特定波长的一个或多个能量脉冲发射到目标区域的方法,从目标区域滤出一个或多个返回波长,以及基于滤波来确定是否结合荧光 还提供了波长和源波长。 还提供了相关联的系统。
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公开(公告)号:US07645946B2
公开(公告)日:2010-01-12
申请号:US11383237
申请日:2006-05-15
申请人: Jeffrey M. Smith
发明人: Jeffrey M. Smith
IPC分类号: H02G3/18
摘要: Two symmetrical pieces form an escutcheon that seals the gap between a pipe or conduit and the surface through which it penetrates and supports the pipe or conduit. The device is surface mounted with threaded mechanical fasteners which can be adjusted to vary the compression of the sealing gaskets. The escutcheon can be installed without requiring any manipulation of the pipe or conduit. The escutcheon can be removed and reinstalled repeatedly without any degradation in function.
摘要翻译: 两个对称的部件形成密封件,其密封管道或管道与其穿透的表面之间的间隙并且支撑管道或导管。 该装置表面安装有螺纹机械紧固件,其可以被调节以改变密封垫圈的压缩。 可以安装孔罩,而不需要对管道或管道进行任何操纵。 盖帽可以重复移除并重新安装,不会造成任何功能的退化。
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公开(公告)号:US5859588A
公开(公告)日:1999-01-12
申请号:US896868
申请日:1997-07-18
CPC分类号: F41H9/10 , G08B15/004 , G08B15/02 , Y10S116/44
摘要: A personal safety device including a handbag with pepper spray and air siren cannisters stored therein, a button on the handle of the handbag activating a switch to actuate the cannisters, the pepper spray being dispersed through a hole in the handle, the air siren being directed through a vent in the handbag, and including a safety lock in the handle to prevent accidental dispersion of the cannisters.
摘要翻译: 一种个人安全装置,其中包括一个储存在其中的胡椒喷雾手提袋和空气警笛罐,手提包手柄上的按钮启动一个开关以致动食管,胡椒喷雾通过把手中的一个孔分散,空气警报器被导向 通过手提包中的通风口,并且在手柄中包括安全锁以防止食盒的意外分散。
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