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公开(公告)号:US07488758B2
公开(公告)日:2009-02-10
申请号:US11133722
申请日:2005-05-20
申请人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号: A61K31/135 , C07C211/00
CPC分类号: C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要: The invention is directed to levalbuterol HCl Form B and methods of making the same.
摘要翻译: 本发明涉及盐酸左沙利度胺HCl及其制备方法。
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公开(公告)号:US20050267216A1
公开(公告)日:2005-12-01
申请号:US11133722
申请日:2005-05-20
申请人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号: A61K31/135 , A61K31/137 , A61K31/195 , A61K31/24 , A61P11/00 , C07C213/10 , C07C215/60 , C07C217/48 , C07C227/34 , C07C229/00 , C07C229/38
CPC分类号: C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要: The invention is directed to levalbuterol HCl Form B and methods of making the same.
摘要翻译: 本发明涉及盐酸左沙利度胺HCl及其制备方法。
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公开(公告)号:US07465831B2
公开(公告)日:2008-12-16
申请号:US11827481
申请日:2007-07-11
申请人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号: C07C213/08 , C07C213/10
CPC分类号: C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
摘要翻译: 本发明涉及通过在至少第一有机溶剂中悬浮或形成(R)-SLB(D)-DBTA的第一浆液,将HCl添加到固体的悬浮液或浆液中来制备盐酸莱布丁醇多晶型A的方法 R)-SLB.D-DBTA,直到(R)-SLB.D-DBTA形成左美沙芬醇多晶型A,并分离左氯沙坦醇多晶型物A.
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公开(公告)号:US20080021244A1
公开(公告)日:2008-01-24
申请号:US11827481
申请日:2007-07-11
申请人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号: C07C213/00
CPC分类号: C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
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公开(公告)号:US20050272821A1
公开(公告)日:2005-12-08
申请号:US11133720
申请日:2005-05-20
申请人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号: A61K31/135 , A61K31/137 , A61K31/195 , A61K31/24 , A61P11/00 , C07C213/10 , C07C215/60 , C07C217/48 , C07C227/34 , C07C229/00 , C07C229/38
CPC分类号: C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
摘要翻译: 本发明涉及通过在至少第一有机溶剂中悬浮或形成(R)-SLB(D)-DBTA的第一浆液,将HCl添加到固体的悬浮液或浆液中来制备盐酸莱布丁醇多晶型A的方法 R)-SLB.D-DBTA,直到(R)-SLB.D-DBTA形成左美沙芬醇多晶型A,并分离左氯沙坦醇多晶型物A.
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公开(公告)号:US20080312471A1
公开(公告)日:2008-12-18
申请号:US12228317
申请日:2008-08-11
申请人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
发明人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
IPC分类号: C07C211/01
CPC分类号: C07C217/48
摘要: The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
摘要翻译: 本发明提供了以盐酸阿托西汀形式B和C的新型结晶多晶型形式及其制备方法,以及制备形式A的方法。本发明提供药物组合物,其包含盐酸阿托西汀形式B,C型或 可用于治疗注意力缺陷/多动障碍的混合物。
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公开(公告)号:US07473804B2
公开(公告)日:2009-01-06
申请号:US11187349
申请日:2005-07-21
申请人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
发明人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
IPC分类号: C07C213/08 , C07C217/62 , A61K31/135
CPC分类号: C07C217/48
摘要: The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
摘要翻译: 本发明提供了以盐酸阿托西汀形式B和C的新型结晶多晶型形式及其制备方法,以及制备形式A的方法。本发明提供药物组合物,其包含盐酸阿托西汀形式B,C型或 可用于治疗注意力缺陷/多动障碍的混合物。
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公开(公告)号:US20060079581A1
公开(公告)日:2006-04-13
申请号:US11187349
申请日:2005-07-21
申请人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
发明人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
IPC分类号: A61K31/138 , C07C217/54
CPC分类号: C07C217/48
摘要: The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
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公开(公告)号:US20100076225A1
公开(公告)日:2010-03-25
申请号:US12584623
申请日:2009-12-03
申请人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
发明人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
IPC分类号: C07C213/00
CPC分类号: C07C217/48
摘要: The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
摘要翻译: 本发明提供了以盐酸阿托西汀形式B和C的新型结晶多晶型形式及其制备方法,以及制备形式A的方法。本发明提供药物组合物,其包含盐酸阿托西汀形式B,C型或 可用于治疗注意力缺陷/多动障碍的混合物。
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公开(公告)号:US07439399B2
公开(公告)日:2008-10-21
申请号:US11219785
申请日:2005-09-07
申请人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
发明人: Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
IPC分类号: C07C213/08
CPC分类号: C07C213/10 , C07B2200/13 , C07C213/06 , C07C213/08 , C07C217/16 , C07C217/48
摘要: The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.
摘要翻译: 在提高反应产率和促进商业合成的反应条件下,本发明提供了制备盐酸阿托西汀的改进方法。 特别地,本发明涉及通过向(R) - ( - ) - 托莫西汀(S) - (+) - 扁桃酸酯与有机溶剂,有或没有碱和水的混合物中加入HCl来合成阿托莫西汀HCl 。 在优选的实施方案中,产生的阿莫西汀盐酸盐是形式A.
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