专利检索 ap:("Valo Early Discovery, Inc.") AND inv:"David R. Lancia, Jr." 第 1 页

1.

发明授权
Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors 有权

公开(公告)号：US11739071B2

公开(公告)日：2023-08-29

申请号：US17096349

申请日：2020-11-12

申请人： Valo Early Discovery, Inc.

发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.

IPC分类号： C07D401/06 , C07D239/88 , C07D487/04 , C07D471/04

CPC分类号： C07D401/06 , C07D239/88 , C07D471/04 , C07D487/04

摘要： The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula:

where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

2.

发明授权
[6,6] fused bicyclic HDAC8 inhibitors 有权

公开(公告)号：US10829460B2

公开(公告)日：2020-11-10

申请号：US16449675

申请日：2019-06-24

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Jennifer R. Thomason , Mary-Margaret Zablocki , Bingsong Han , Nicholas Barczak , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair

IPC分类号： C07D265/36 , C07D413/12 , C07D413/06 , C07D401/04 , C07D279/16 , C07D491/107 , C07D413/10 , C07D471/04 , C07D417/06 , C07D513/04 , C07D487/04 , C07D265/34 , C07D279/14

摘要： The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein, useful as inhibitors of zinc-dependent histone deacetylases (HDACs) and in the treatment of diseases or disorders associated with HDACs.

3.

发明授权
3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US10988450B2

公开(公告)日：2021-04-27

申请号：US16567007

申请日：2019-09-11

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Heather Davis , Aleksandra Rudnitskaya , David R. Lancia, Jr. , Kenneth W. Bair , David S. Millan , Matthew W. Martin

IPC分类号： C07D491/08 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

4.

发明授权
Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors 有权

公开(公告)号：US10934299B2

公开(公告)日：2021-03-02

申请号：US16517149

申请日：2019-07-19

申请人： Valo Early Discovery, Inc.

发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , Darby Rye Schmidt , David Joseph Guerin , Justin Andrew Caravella , R. Bruce Diebold , Anna Ericsson , David R. Lancia, Jr.

IPC分类号： C07D487/04 , C07D519/00 , A61K31/519

摘要： The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

5.

发明授权
Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors 有权

公开(公告)号：US10906916B2

公开(公告)日：2021-02-02

申请号：US16515194

申请日：2019-07-18

申请人： Valo Early Discovery, Inc.

发明人： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.

IPC分类号： C07D495/04 , A61K31/519

摘要： The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.

6.

发明授权
Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors 有权

公开(公告)号：US10889592B2

公开(公告)日：2021-01-12

申请号：US16077406

申请日：2017-02-13

申请人： VALO EARLY DISCOVERY, INC.

发明人： David Joseph Guerin , Kenneth W. Bair , Justin A. Caravella , Stephanos Ioannidis, Jr. , David R. Lancia, Jr. , Hongbin Li , Steven Mischke , Pui Yee Ng , David Richard , Shawn E. R. Schiller , Tatiana Shelekhin , Zhongguo Wang

IPC分类号： C07D495/04

摘要： The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4′, R5, R6, X, and n are described herein.

7.

发明授权
3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US10829461B2

公开(公告)日：2020-11-10

申请号：US16654704

申请日：2019-10-16

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , David S. Millan , Matthew W. Martin

IPC分类号： A61K31/553 , C07D267/14 , C07D407/06 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

8.

发明授权
Alpha-cinnamide compounds and compositions as HDAC8 inhibitors 有权

公开(公告)号：US10988441B2

公开(公告)日：2021-04-27

申请号：US16689252

申请日：2019-11-20

申请人： Valo Early Discovery, Inc.

发明人： Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary-Margaret Zablocki , Xiaozhang Zheng

IPC分类号： C07C259/06 , A61K31/185 , C07D221/20 , A61K31/438 , A61K31/277 , C07D209/44 , A61K31/4035 , C07D295/155 , A61K31/451 , C07D471/10 , A61K31/435 , C07D487/10 , A61K31/407 , C07D495/10 , A61K31/397 , C07D235/14 , A61K31/4184 , C07D233/68 , A61K31/417 , C07D213/56 , A61K31/44 , C07D241/08 , A61K31/495 , C07D417/04 , A61K31/4439 , A61K31/5377 , C07D471/04 , C07D401/14 , C07D213/75 , C07D213/81 , C07D215/12 , C07D317/68 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D333/70 , C07D401/04 , C07D401/12 , C07D235/30 , C07D239/20 , C07D239/22 , C07D405/12 , C07D409/04 , C07D409/12 , C07D241/12 , C07D417/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D487/04 , C07D487/08 , C07D491/10 , C07D207/10 , C07D493/08 , C07D207/267 , C07D498/04 , C07D209/08 , C07D277/56 , C07D209/42 , C07D209/46 , C07D513/10 , C07D211/16 , C07D211/58 , C07D295/192 , C07D213/65 , C07D307/68

摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

9.

发明授权
3-alkyl bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US10829462B2

公开(公告)日：2020-11-10

申请号：US16662131

申请日：2019-10-24

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , David S. Millan , Matthew W. Martin , Kenneth W. Bair

IPC分类号： A61K31/553 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.

10.

发明授权
3-aryl-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors 有权

公开(公告)号：US10822316B2

公开(公告)日：2020-11-03

申请号：US16660015

申请日：2019-10-22

申请人： Valo Early Discovery, Inc.

发明人： Xiaozhang Zheng , Pui Yee Ng , Bingsong Han , Jennifer R. Thomason , Mary-Margaret Zablocki , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, Jr. , David S. Millan , Matthew W. Martin

IPC分类号： A61K31/553 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/04 , C07D267/12 , C07D243/14 , C07D291/08 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C07D498/08 , C07D493/08 , C07D413/08 , C07D491/107 , C07D495/10

摘要： The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.