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公开(公告)号：US10039761B2
公开(公告)日：2018-08-07
申请号：US15130266
申请日：2016-04-15
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC: A61K31/33 , A61K31/506 , C07D401/14 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , A61K45/06 , C07B59/00 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07K16/28 , A61N5/10
CPC classification number: A61K31/506 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/39558 , A61K45/06 , A61N2005/1098 , A61P35/00 , C07B59/002 , C07B2200/05 , C07B2200/13 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07D401/14 , C07K16/2863 , C07K2317/24
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：US20180325897A1
公开(公告)日：2018-11-15
申请号：US16038696
申请日：2018-07-18
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC: A61K31/506 , C07K16/28 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/337 , C07D401/14 , C07C63/08 , C07C59/265 , C07C57/15 , C07C57/145 , C07C55/14 , C07C55/10 , C07B59/00 , A61K45/06 , A61K39/395 , A61K38/14 , A61K33/24 , A61K31/7048 , A61K31/704 , A61K31/555 , A61N5/10
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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公开(公告)号：US10716789B2
公开(公告)日：2020-07-21
申请号：US16038696
申请日：2018-07-18
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael P. Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC: A61K31/506 , C07D401/14 , A61P35/00 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , A61K45/06 , C07B59/00 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07K16/28 , A61N5/10
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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4.发明申请CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 有权CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂的共晶体
公开(公告)号：US20160096807A1
公开(公告)日：2016-04-07
申请号：US14877914
申请日：2015-10-07
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Mark Strohmeier , John Caesar, JR. , Patrick Raymond Connelly , Majed Fawaz , Eduard Luss-Lusis , Brian McClain , Ales Medek , Hai Miao , Kwame Wiredu Nti-Addae , Ping Yin , Yuegang Zhang
IPC: C07D215/56 , A61K45/06 , A61K31/225 , C07C69/34 , A61K31/47
CPC classification number: C07D215/56 , A61K31/225 , A61K31/47 , A61K45/06 , C07B2200/13 , C07C69/18 , C07C69/30 , C07C69/34 , C07C69/58 , C07C69/587
Abstract: The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.
Abstract translation: 本公开内容涉及包含N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）和共 - 成型机及其制备方法。 本公开还涉及包含共晶形式的药物组合物，以及其治疗方法和试剂盒。
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公开(公告)号：US09701639B2
公开(公告)日：2017-07-11
申请号：US14877914
申请日：2015-10-07
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Mark Strohmeier , John Caesar, Jr. , Patrick Raymond Connelly , Majed Fawaz , Eduard Luss-Lusis , Brian McClain , Ales Medek , Hai Miao , Kwame Wiredu Nti-Addae , Ping Yin , Yuegang Zhang
IPC: C07D215/56 , A61K31/225 , A61K31/47 , A61K45/06 , C07C69/34
CPC classification number: C07D215/56 , A61K31/225 , A61K31/47 , A61K45/06 , C07B2200/13 , C07C69/18 , C07C69/30 , C07C69/34 , C07C69/58 , C07C69/587
Abstract: The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.
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公开(公告)号：US20160339024A1
公开(公告)日：2016-11-24
申请号：US15130266
申请日：2016-04-15
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
IPC: A61K31/506 , C07D401/14 , C07B59/00 , C07C55/14 , C07C55/10 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , A61K31/337 , A61K31/555 , A61K31/517 , A61K31/7048 , A61K31/704 , A61K38/14 , A61K31/5025 , A61K33/24 , A61K31/513 , A61K39/395 , C07K16/28 , A61K45/06
CPC classification number: A61K31/506 , A61K31/337 , A61K31/5025 , A61K31/513 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/39558 , A61K45/06 , A61N2005/1098 , C07B59/002 , C07B2200/05 , C07B2200/13 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C59/265 , C07C63/08 , C07D401/14 , C07K16/2863 , C07K2317/24
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
Abstract translation: 其中R1和R2各自为H或2H，选自己二酸，柠檬酸，富马酸，马来酸，琥珀酸或苯甲酸的共晶体形成剂。 在本发明的范围内也是制造和使用本发明的方法。
