-
公开(公告)号:US20120122847A1
公开(公告)日:2012-05-17
申请号:US13157195
申请日:2011-06-09
申请人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Zihao Hua , Matthew Martin , Issac Marx , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
发明人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Zihao Hua , Matthew Martin , Issac Marx , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
IPC分类号: A61K31/502 , A61P35/00 , C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/55
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1-8,D',L1,L2,R1,R6-8和n定义在本文中,以及合成中间体,其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节Aurora激酶,从而影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与Aurora激酶活性有关的疾病状态的方法。
-
公开(公告)号:US07776857B2
公开(公告)日:2010-08-17
申请号:US12080669
申请日:2008-04-03
申请人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Matthew Martin , Isaac Marx , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
发明人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Matthew Martin , Isaac Marx , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
IPC分类号: C07D237/30
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1-8,D',L1,L2,R1,R6-8和n定义在本文中,以及合成中间体,其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节Aurora激酶,从而影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与Aurora激酶活性有关的疾病状态的方法。
-
公开(公告)号:US20090069297A1
公开(公告)日:2009-03-12
申请号:US12080669
申请日:2008-04-03
申请人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Mathew Martin , Isaac Marx , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
发明人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Mathew Martin , Isaac Marx , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
IPC分类号: A61K31/502 , C07D237/30 , A61K31/55 , A61P35/00 , C07D403/14
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1-8,D',L1,L2,R1,R6-8和n定义在本文中,以及合成中间体,其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节Aurora激酶,从而影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与Aurora激酶活性有关的疾病状态的方法。
-
公开(公告)号:US20100280008A1
公开(公告)日:2010-11-04
申请号:US12828067
申请日:2010-06-30
申请人: Holly Deak , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Matthew Martin , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
发明人: Holly Deak , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Matthew Martin , Hanh Nho Nguyen , Philip Olivieri , Kathleen Panter , Karina Romero , Laurie Schenkel , Ryan White
IPC分类号: A61K31/55 , A61K31/5377 , A61K31/502 , C07D413/14 , C07D401/14 , C07D401/12 , A61P35/00
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1-8,D',L1,L2,R1,R6-8和n定义在本文中,以及合成中间体,其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节Aurora激酶,从而影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与Aurora激酶活性有关的疾病状态的方法。
-
公开(公告)号:US07981891B2
公开(公告)日:2011-07-19
申请号:US12828067
申请日:2010-06-30
申请人: Holly Deak , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Mathew Martin , Hanh Nho Nguyen , Philip Olivieri , Kate Panter , Karina Romero , Laurie Schenkel , Ryan White
发明人: Holly Deak , Stephanie Geuns-Meyer , Brian L. Hodous , Zihao Hua , Mathew Martin , Hanh Nho Nguyen , Philip Olivieri , Kate Panter , Karina Romero , Laurie Schenkel , Ryan White
IPC分类号: A61K31/502
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1-8,D',L1,L2,R1,R6-8和n定义在本文中,以及合成中间体,其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如,化合物能够调节Aurora激酶,从而影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与Aurora激酶活性有关的疾病状态的方法。
-
公开(公告)号:US20070185111A1
公开(公告)日:2007-08-09
申请号:US11655642
申请日:2007-01-18
申请人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Brian Hodous , Hanh Nguyen , Philip Olivieri , Vinod Patel , Karina Romero , Laurie Schenkel
发明人: Victor Cee , Holly Deak , Bingfan Du , Stephanie Geuns-Meyer , Brian Hodous , Hanh Nguyen , Philip Olivieri , Vinod Patel , Karina Romero , Laurie Schenkel
IPC分类号: A61K31/53 , A61K31/503 , C07D403/14
CPC分类号: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R1- are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A 1,A 2,C 1,C 2, 本文定义的SUP,D,L 1,L 2,Z和R 1 - 以及能够调节的合成中间体 各种蛋白激酶受体酶,从而影响与这些激酶的活性相关的各种疾病状态和病症。 例如,化合物能够调节Aurora激酶,从而影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,包括该化合物,以及治疗与Aurora激酶活性有关的疾病状态的方法。
-
公开(公告)号:US08022221B2
公开(公告)日:2011-09-20
申请号:US12378426
申请日:2009-02-12
申请人: Victor J. Cee , Holly L. Deak , Bingfan Du , Stephanie D. Geuns-Meyer , Brian L. Hodous , Hanh Nho Nguyen , Philip R. Olivieri , Vinod F. Patel , Karina Romero , Laurie Schenkel
发明人: Victor J. Cee , Holly L. Deak , Bingfan Du , Stephanie D. Geuns-Meyer , Brian L. Hodous , Hanh Nho Nguyen , Philip R. Olivieri , Vinod F. Patel , Karina Romero , Laurie Schenkel
IPC分类号: C07D401/14 , C07D403/14 , A61K31/53 , A61K31/4427 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1,A2,C1,C2,D,L1,L2,Z和R3,R4,R6,R7和R8如本文所定义,其能够调节极光激酶蛋白 活动,从而影响与Aurora激酶蛋白活性相关的各种疾病状态和病症。 例如,化合物能够影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,制备本发明化合物的方法,合成中间体和治疗与Aurora激酶活性有关的病症的方法。
-
公开(公告)号:US20110263530A1
公开(公告)日:2011-10-27
申请号:US13171355
申请日:2011-06-28
申请人: Victor J. CEE , Holly L. Deak , Bingfan Du , Stephanie D. Geuns-Meyer , Brian L. Hodous , Hanh Nho Nguyen , Philip R. Olivieri , Vinod F. Patel , Karina Romero , Laurie Schenkel
发明人: Victor J. CEE , Holly L. Deak , Bingfan Du , Stephanie D. Geuns-Meyer , Brian L. Hodous , Hanh Nho Nguyen , Philip R. Olivieri , Vinod F. Patel , Karina Romero , Laurie Schenkel
IPC分类号: A61K31/69 , A61K31/50 , C07D401/12 , A61K31/502 , A61K31/444 , C07F5/04 , C07D401/14 , A61K31/501 , C07F9/6561 , A61K31/675 , C07D471/04 , A61K31/437 , A61K31/506 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P35/02 , C07D237/20
CPC分类号: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1,A2,C1,C2,D,L1,L2,Z和R3,R4,R6,R7和R8如本文所定义,其能够调节极光激酶蛋白 活动,从而影响与Aurora激酶蛋白活性相关的各种疾病状态和病症。 例如,化合物能够影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,制备本发明化合物的方法,合成中间体和治疗与Aurora激酶活性有关的病症的方法。
-
公开(公告)号:US08557816B2
公开(公告)日:2013-10-15
申请号:US13157195
申请日:2011-06-09
IPC分类号: A61K31/502
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14 , C07D487/04 , C07D493/04 , C07D495/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
-
公开(公告)号:US20090163501A1
公开(公告)日:2009-06-25
申请号:US12378426
申请日:2009-02-12
申请人: Victor J. Cee , Holly L. Deak , Bingfan Du , Stephanie D. Genus-Meyer , Brain L. Hodous , Han Nho Nguyen , Philip R. Olivieri , Vinod F. Patel , Karina Romero , Laurie Schenkel
发明人: Victor J. Cee , Holly L. Deak , Bingfan Du , Stephanie D. Genus-Meyer , Brain L. Hodous , Han Nho Nguyen , Philip R. Olivieri , Vinod F. Patel , Karina Romero , Laurie Schenkel
IPC分类号: A61K31/502 , C07D251/20 , C07D413/14 , C07D237/30 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
摘要: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
摘要翻译: 本发明涉及具有通式I的化合物,其中A1,A2,C1,C2,D,L1,L2,Z和R3,R4,R6,R7和R8如本文所定义,其能够调节极光激酶蛋白 活动,从而影响与Aurora激酶蛋白活性相关的各种疾病状态和病症。 例如,化合物能够影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,制备本发明化合物的方法,合成中间体和治疗与Aurora激酶活性有关的病症的方法。
-
-
-
-
-
-
-
-
-