Multi-cyclic compounds and methods of use
    7.
    发明授权
    Multi-cyclic compounds and methods of use 失效
    多环化合物和使用方法

    公开(公告)号:US08236823B2

    公开(公告)日:2012-08-07

    申请号:US11977970

    申请日:2007-10-25

    IPC分类号: A61K31/4439 C07D401/04

    摘要: The present invention relates to compounds of Formulas I and II, wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.

    摘要翻译: 本发明涉及式I和II的化合物,其中B1,B2,B3,B4,C1,C2,环D,L1,L2和R1-4在本文中定义,合成中间体和包含这些化合物的药物组合物。 化合物和组合物能够调节各种蛋白激酶受体如Tie-2和Aurora,因此影响激酶相关的疾病状态和状况。 该化合物例如能够治疗由不受调节的血管发生,炎症以及其它增殖性疾病引起的癌症。

    Multi-cyclic compounds and methods of use
    8.
    发明授权
    Multi-cyclic compounds and methods of use 有权
    多环化合物和使用方法

    公开(公告)号:US08822514B2

    公开(公告)日:2014-09-02

    申请号:US13490337

    申请日:2012-06-06

    摘要: The present invention relates to compounds of Formulas I and II, wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.

    摘要翻译: 本发明涉及式I和II的化合物,其中B1,B2,B3,B4,C1,C2,环D,L1,L2和R1-4在本文中定义,合成中间体和包含这些化合物的药物组合物。 化合物和组合物能够调节各种蛋白激酶受体如Tie-2和Aurora,因此影响激酶相关的疾病状态和状况。 该化合物例如能够治疗由不受调节的血管发生,炎症以及其它增殖性疾病引起的癌症。