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公开(公告)号:US07358093B2
公开(公告)日:2008-04-15
申请号:US11723867
申请日:2007-03-22
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号: G01N33/15 , G01N21/94 , C07D205/085
CPC分类号: C07D417/12 , C07C229/26 , Y10T436/145555
摘要: The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译: 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
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公开(公告)号:US20050032775A1
公开(公告)日:2005-02-10
申请号:US10882591
申请日:2004-07-01
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号: A61P11/00 , A61P31/04 , C07C229/26 , C07D417/12 , A61K31/397 , C07D205/08
CPC分类号: C07D417/12 , C07C229/26 , Y10T436/145555
摘要: The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译: 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
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公开(公告)号:US07262293B2
公开(公告)日:2007-08-28
申请号:US10882591
申请日:2004-07-01
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号: C07D417/12
CPC分类号: C07D417/12 , C07C229/26 , Y10T436/145555
摘要: The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
摘要翻译: 本发明涉及氨曲南的L-赖氨酸盐和制备氨曲南的L-赖氨酸盐的方法。
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公开(公告)号:US20070167424A1
公开(公告)日:2007-07-19
申请号:US11723867
申请日:2007-03-22
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer , Istvan Bodi
IPC分类号: A61K31/427 , C07D417/02
CPC分类号: C07D417/12 , C07C229/26 , Y10T436/145555
摘要: The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam.
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公开(公告)号:US07452991B2
公开(公告)日:2008-11-18
申请号:US10847123
申请日:2004-05-17
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer , Ehud Amir
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer , Ehud Amir
IPC分类号: C07D205/085
CPC分类号: C07D417/12
摘要: The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph. In the process of the invention, a polymorph of Aztreonam is dissolved in an absolute C1-6 alcohol in the presence of a base to form a solution, an acid is added to the solution, and the solution is stirred efficiently.
摘要翻译: 本发明涉及氨曲南的β多晶型物,其含有小于2.5%(重量)的残留溶剂和制备所述多晶型物的方法。 在本发明的方法中,在碱的存在下将氨丁三醇的多晶型物溶解在绝对的C 1-6醇中以形成溶液,向溶液中加入酸,并将溶液 被有效地搅拌。
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公开(公告)号:US07145017B2
公开(公告)日:2006-12-05
申请号:US10635659
申请日:2003-08-05
IPC分类号: C07D277/20
CPC分类号: C07D417/12
摘要: The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreonam) to form Aztreonam.
摘要翻译: 本发明涉及一种合成氨曲南的方法。 具体来说,该方法需要水解[3S- [3α(Z),4] 3 - [[(2-氨基-4-噻唑基)[(1-叔丁氧基羰基-1-甲基乙氧基)亚氨基]乙酰基]氨基] -4-甲基-2-氧代-1-氮杂环丁烷磺酸(t-Bu阿兹曲南)以形成氨曲南。
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公开(公告)号:US20050014739A1
公开(公告)日:2005-01-20
申请号:US10847123
申请日:2004-05-17
申请人: Viktor Gyollai , Csaba Szabo , Claude Singer
发明人: Viktor Gyollai , Csaba Szabo , Claude Singer
IPC分类号: C07D417/12 , A61K31/397 , C07D205/08
CPC分类号: C07D417/12
摘要: The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph.
摘要翻译: 本发明涉及氨曲南的β多晶型物,其含有小于2.5%(重量)的残留溶剂和制备所述多晶型物的方法。
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公开(公告)号:US20060147540A1
公开(公告)日:2006-07-06
申请号:US11293283
申请日:2005-12-01
申请人: Adrienne Kovacsne-Mezei , Csilla Racz , Judith Aronhime , Csaba Szabo , Viktor Gyollai , Sandor Molnar , Micahel Pinchasov
发明人: Adrienne Kovacsne-Mezei , Csilla Racz , Judith Aronhime , Csaba Szabo , Viktor Gyollai , Sandor Molnar , Micahel Pinchasov
IPC分类号: A61K31/4745 , C07D267/22 , A61K9/14
CPC分类号: C07D498/18 , A61K9/145 , A61K9/1688 , A61K31/4745 , C07D491/14 , C07H19/01
摘要: An amorphous pimecrolimus and processes for providing an amorphous pimecrolimus are provided.
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公开(公告)号:US07279571B2
公开(公告)日:2007-10-09
申请号:US11293353
申请日:2005-12-01
申请人: Viktor Gyollai , Csaba Szabo
发明人: Viktor Gyollai , Csaba Szabo
IPC分类号: C07D498/18
CPC分类号: C07D498/18 , A61K9/145 , A61K9/1688 , A61K31/4745 , C07D491/14 , C07H19/01
摘要: The present invention provides a process for the preparation of pimecrolimus from ascomycin in which ascomycin is reacted with a conversion reagent that converts ascomycin to its activated derivative at C-32. The activated ascomycin is then reacted with chloride ion. The process of the invention requires fewer process steps than prior art processes, and does not require the protection of the ascomycin C-24 hydroxyl group or the purification of the activated ascomycin derivative.
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公开(公告)号:US07589100B2
公开(公告)日:2009-09-15
申请号:US11293283
申请日:2005-12-01
申请人: Adrienne Kovacsne-Mezei , Csilla Nemethne Racz , Judith Aronhime , Csaba Szabo , Viktor Gyollai , Sandor Molnar , Micahel Pinchasov
发明人: Adrienne Kovacsne-Mezei , Csilla Nemethne Racz , Judith Aronhime , Csaba Szabo , Viktor Gyollai , Sandor Molnar , Micahel Pinchasov
IPC分类号: C07D498/18 , A61K31/395 , A61P17/00
CPC分类号: C07D498/18 , A61K9/145 , A61K9/1688 , A61K31/4745 , C07D491/14 , C07H19/01
摘要: An amorphous pimecrolimus and processes for providing an amorphous pimecrolimus are provided.
摘要翻译: 提供无定形吡美莫司和提供无定形吡美莫司的方法。
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