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    Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
    1.
    发明申请
    Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe 审中-公开
    制备（3R，4S）-4 - （（4-苄氧基）苯基）-1-（4-氟苯基）-3 - （（S）-3-（4-氟苯基）-3-羟丙基） - 2-氮杂环丁酮，合成依泽替米贝的中间体

    公开(公告)号：US20070259845A1

    公开(公告)日：2007-11-08

    申请号：US11517704

    申请日：2006-09-08

    申请人： Vinod Kansal ,  Suhail Ahmad ,  Bhupendra Tyagi ,  Nitin Gupta ,  Nurit Perlman

    发明人： Vinod Kansal ,  Suhail Ahmad ,  Bhupendra Tyagi ,  Nitin Gupta ,  Nurit Perlman

    IPC分类号： A61K31/397 ,  A61P9/12 ,  C07D205/00

    CPC分类号： C07D205/08 ,  Y02P20/55

    摘要： The invention encompasses (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-2-azetidinone (Compound 2a) having an enantiomeric purity of at least about 97.5%. The invention also encompasses Compound 2a having a chemical purity of at least about 97%. The invention further encompasses processes for preparing Compound 2a from Compound 1 having the following formula: The invention also encompasses processes for preparing a compound having the following formula: from a compound having the following formula: wherein R is selected from the group consisting of: H or a hydroxyl protecting group. The invention also encompasses processes for preparing Compound 2a, preferably to form Compound 2a-Form 01. Also included are processes for preparing ezetimibe from Compound 2a-Form 01 or Compound 2a prepared according to the invention, compositions containing such ezetimibe, and methods for reducing cholesterol using such compositions.

    摘要翻译： 本发明包括（3R，4S）-4 - （（4-苄氧基）苯基）-1-（4-氟苯基）-3-（3-（4-氟苯基）-3-氧代丙基）-2-氮杂环丁酮（化合物2a ）具有至少约97.5％的对映体纯度。 本发明还包括具有至少约97％的化学纯度的化合物2a。 本发明还包括从具有下式的化合物1制备化合物2a的方法：本发明还包括由具有下式的化合物制备具有下式的化合物的方法：其中R选自：H 或羟基保护基。 本发明还包括制备化合物2a，优选形成化合物2a-形式01的方法。还包括用于制备根据本发明制备的化合物2a-形式01或化合物2a的依泽替米贝的方法，含有这种依泽替米贝的组合物，以及还原方法 使用这种组合物的胆固醇。

    Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
    2.
    发明申请
    Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe 审中-公开
    制备（3R，4S）-4 - （（4-苄氧基）苯基）-1-（4-氟苯基）-3 - （（S）-3-（4-氟苯基）-3-羟丙基） - 2-氮杂环丁酮，合成依泽替米贝的中间体

    公开(公告)号：US20100010212A1

    公开(公告)日：2010-01-14

    申请号：US12583305

    申请日：2009-08-17

    申请人： Vinod Kumar Kansal ,  Suhail Ahmad ,  Bhupendra Tyagi ,  Nitin Gupta

    发明人： Vinod Kumar Kansal ,  Suhail Ahmad ,  Bhupendra Tyagi ,  Nitin Gupta

    IPC分类号： C07D205/08 ,  A61K31/397

    CPC分类号： C07D205/08 ,  Y02P20/55

    摘要： The invention encompasses (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-2-azetidinone (Compound 2a) having an enantiomeric purity of at least about 97.5%. The invention also encompasses Compound 2a having a chemical purity of at least about 97%. The invention further encompasses processes for preparing Compound 2a from Compound 1 having the following formula: The invention also encompasses processes for preparing a compound having the following formula: from a compound having the following formula: wherein R is selected from the group consisting of: H or a hydroxyl protecting group. The invention also encompasses processes for preparing Compound 2a, preferably to form Compound 2a-Form 01. Also included are processes for preparing ezetimibe from Compound 2a-Form 01 or Compound 2a prepared according to the invention, compositions containing such ezetimibe, and methods for reducing cholesterol using such compositions

    摘要翻译： 本发明包括（3R，4S）-4 - （（4-苄氧基）苯基）-1-（4-氟苯基）-3-（3-（4-氟苯基）-3-氧代丙基）-2-氮杂环丁酮（化合物2a ）具有至少约97.5％的对映体纯度。 本发明还包括具有至少约97％的化学纯度的化合物2a。 本发明还包括从具有下式的化合物1制备化合物2a的方法：本发明还包括由具有下式的化合物制备具有下式的化合物的方法：其中R选自：H 或羟基保护基。 本发明还包括制备化合物2a，优选形成化合物2a-形式01的方法。还包括用于制备根据本发明制备的化合物2a-形式01或化合物2a的依泽替米贝的方法，含有这种依泽替米贝的组合物，以及还原方法 使用这种组合物的胆固醇

    Name Disambiguation Using Context Terms
    5.
    发明申请
    Name Disambiguation Using Context Terms 有权
    使用上下文术语命名消歧

    公开(公告)号：US20140214840A1

    公开(公告)日：2014-07-31

    申请号：US12955253

    申请日：2010-11-29

    申请人： Nitin Gupta ,  Abhinandan S. Das

    发明人： Nitin Gupta ,  Abhinandan S. Das

    IPC分类号： G06F17/30

    CPC分类号： G06F17/3064

    摘要： Methods, systems and apparatus, including computer programs encoded on a computer storage medium, for disambiguating names in a document corpus. In an aspect, a method includes generating context term lists for a person name, each context term list being a list of context terms from a resource for the person name; clustering the context term lists into a plurality of clusters, each of the clusters of context term lists including context term lists that are most similar to the cluster relative to other clusters; for each of the clusters, selecting a representative term for the cluster; receiving the person name as a search query; and generating a plurality of query suggestions from the search query and the representative terms for the clusters, each query suggesting being a combination of the person name and one representative term.

    摘要翻译： 方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于消除文档语料库中的名称。 一方面，一种方法包括为个人名称生成上下文词列表，每个上下文词列表是来自人名的资源的上下文术语列表; 将上下文术语列表聚类成多个集群，每个上下文术语表的集群包括与集群相对于其他集群最相似的上下文术语列表; 对于每个集群，选择集群的代表性术语; 接收人名作为搜索查询; 以及从所述搜索查询和所述群集的代表性条件生成多个查询建议，每个查询建议是所述人名和一个代表词的组合。

    Automatic framing selection
    6.
    发明授权
    Automatic framing selection 有权
    自动选框

    公开(公告)号：US08792493B2

    公开(公告)日：2014-07-29

    申请号：US13491501

    申请日：2012-06-07

    申请人： David Tze-Si Wu ,  Soren Lasen ,  Kartik Subbana ,  Nitin Gupta ,  Vivasvat Keswani

    发明人： David Tze-Si Wu ,  Soren Lasen ,  Kartik Subbana ,  Nitin Gupta ,  Vivasvat Keswani

    IPC分类号： H04L12/28 ,  H04L12/26 ,  H04L12/56

    CPC分类号： H04L47/27 ,  H04L12/28 ,  H04L43/16 ,  H04L47/26 ,  H04L69/16 ,  H04L69/163

    摘要： Network traffic is monitored and an optimal framing heuristic is automatically determined and applied. Framing heuristics specify different rules for framing network traffic. While a framing heuristic is applied to the network traffic, alternative framing heuristics are speculatively evaluated for the network traffic. The results of these evaluations are used to rank the framing heuristics. The framing heuristic with the best rank is selected for framing subsequent network traffic. Each client/server traffic flow may have a separate framing heuristic. The framing heuristics may be deterministic based on byte count and/or time or based on traffic characteristics that indicate a plausible point for framing to occur. The choice of available framing heuristics may be determined partly by manual configuration, which specifies which framing heuristics are available, and partly by automatic processes, which determine the best framing heuristic to apply to the current network traffic from the set of available framing heuristics.

    摘要翻译： 监控网络流量，并自动确定和应用最优的框架启发式。 成帧启发式规定了组网网络流量的不同规则。 虽然将框架启发式应用于网络流量，但是针对网络流量推测性地评估了替代成帧启发式算法。 这些评估的结果用于对框架启发式进行排序。 选择具有最佳排名的成帧启发式来构建后续网络流量。 每个客户端/服务器流量流可以具有单独的成帧启发式。 帧启发式可以是基于字节计数和/或时间的确定性的，或者基于指示发生框架的合理点的业务特性。 可选帧启发式可以部分地通过手动配置来确定，该手动配置指定哪些帧启发式是可用的，并且部分地由自动进程确定，自动进程决定了应用于可用成帧启发式组的当前网络业务的最佳成帧启发式。

    Distributing ethernet alarm indication signal information to multiple virtual local area networks
    8.
    发明授权
    Distributing ethernet alarm indication signal information to multiple virtual local area networks 有权
    将以太网报警指示信号分配给多个虚拟局域网

    公开(公告)号：US08547832B2

    公开(公告)日：2013-10-01

    申请号：US12728460

    申请日：2010-03-22

    申请人： Nitin Gupta ,  Sonal Shah ,  Aravindan Ramalingam ,  Norman William Finn

    发明人： Nitin Gupta ,  Sonal Shah ,  Aravindan Ramalingam ,  Norman William Finn

    IPC分类号： G01R31/08

    CPC分类号： H04L41/06 ,  H04L12/465 ,  H04L12/467 ,  H04L43/0811

    摘要： Ethernet Alarm Indication Signal (ETH-AIS) information for multiple Virtual Local Area Networks (VLANs) is consolidated and distributed to the multiple VLANs in a single Ethernet frame. Note, as used herein, “Alarm Indication Signal (ETH-AIS)” refers to an IEEE 802.x or ITU-T Y.1731 Ethernet Alarm Indication Signal. A device receiving the Ethernet frame with the consolidated ETH-AIS information typically forwards the frame out each port that communicates traffic for one of the VLANs included in the consolidated ETH-AIS information.

    摘要翻译： 多个虚拟局域网（VLAN）的以太网报警指示信号（ETH-AIS）信息被合并并分发到单个以太网帧中的多个VLAN。 注意，如本文所使用的，“报警指示信号（ETH-AIS）”是指IEEE 802.x或ITU-T Y.1731以太网报警指示信号。 接收具有综合ETH-AIS信息的以太网帧的设备通常将每个端口转发出帧，该端口传送合并的ETH-AIS信息中包含的一个VLAN的流量。

    VIRTUALIZED DATA STORAGE SYSTEM ARCHITECTURE USING PREFETCHING AGENT
    9.
    发明申请
    VIRTUALIZED DATA STORAGE SYSTEM ARCHITECTURE USING PREFETCHING AGENT 审中-公开
    虚拟化数据存储系统架构使用预选代理

    公开(公告)号：US20130232215A1

    公开(公告)日：2013-09-05

    申请号：US13471956

    申请日：2012-05-15

    申请人： Nitin Gupta ,  Nagendra Subramanya ,  Oleg Smolsky

    发明人： Nitin Gupta ,  Nagendra Subramanya ,  Oleg Smolsky

    IPC分类号： G06F15/167

    CPC分类号： G06F3/061 ,  G06F3/0656 ,  G06F3/0662 ,  G06F3/067 ,  G06F12/0862 ,  G06F12/0868 ,  H04L67/1097

    摘要： Virtual storage arrays consolidate data storage from branch locations at data centers. The virtual storage array appears to storage clients as a local data storage; however, the virtual storage array data is actually stored at a data center. To overcome the bandwidth and latency limitations of wide area networks between branch locations and the data center, systems and methods predict, prefetch, and cache at the branch location storage blocks that are likely to be requested in the future by storage clients. When this prediction is successful, storage block requests are fulfilled from branch locations' storage block caches. Predictions may leverage an understanding of the semantics and structure of the high-level data structures associated with the storage blocks. Prefetching agents on storage clients monitor storage requests to determine the associations between requested storage blocks and the corresponding high-level data structures as well as other attributes useful for prediction.

    摘要翻译： 虚拟存储阵列整合数据中心分支机构的数据存储。 虚拟存储阵列对存储客户端显示为本地数据存储; 然而，虚拟存储阵列数据实际上存储在数据中心。 为了克服分支位置和数据中心之间的广域网络的带宽和延迟限制，系统和方法在存储客户端将来可能要求的分支位置存储块中预测，预取和高速缓存。 当该预测成功时，从分支位置的存储块高速缓存中实现存储块请求。 预测可以利用对与存储块相关联的高级数据结构的语义和结构的理解。 存储客户机上的预取代理程序监视存储请求，以确定所请求的存储块与相应的高级数据结构之间的关联以及对预测有用的其他属性。

    High jitter and frequency drift tolerant clock data recovery
    10.
    发明授权
    High jitter and frequency drift tolerant clock data recovery 有权
    高抖动和频率漂移容限时钟数据恢复

    公开(公告)号：US08411811B2

    公开(公告)日：2013-04-02

    申请号：US12841096

    申请日：2010-07-21

    申请人： Nitin Gupta

    发明人： Nitin Gupta

    IPC分类号： H04L7/00

    CPC分类号： H03L7/199 ,  H03L7/0807 ,  H03L7/0812 ,  H03L7/091 ,  H04L7/0337

    摘要： In a method for recovery of a clock from a received digital data stream and an apparatus for recovering a clock from a received digital data stream, phase-shifted clock signals are generated from a receiver's clock. After selecting one of the phase-shifted clock signals, two other phase-shifted clock signals are determined. Depending on sample values taken at rising/falling edges of the three selected phase-shifted clock signals, counter values are increased and compared. The selection of phase-shifted clock signals and the steps of sampling the input digital data stream, comparing the values and increasing counter values, if required, are repeatedly performed until the comparison result of the counter values indicates that one of the latter determined phase-shifted clock signals strobes the received digital data stream in the center of a bit period.

    摘要翻译： 在从接收到的数字数据流中恢复时钟的方法和从接收的数字数据流中恢复时钟的装置中，从接收机的时钟产生相移的时钟信号。 在选择一个相移时钟信号之后，确定另外两个相移时钟信号。 根据在三个选定的相移时钟信号的上升沿/下降沿采集的采样值，增加和比较计数器值。 如果需要，相移时钟信号的选择和对输入数字数据流进行采样的步骤，比较值和增加计数器值，直到计数器值的比较结果指示后一个确定的相位时钟信号之一， 移位的时钟信号在接收到的位数周期的中心选通接收到的数字数据流。