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    TARGETED MORPHOLINO LIGANDS AND USES THEREOF
    6.
    发明申请
    TARGETED MORPHOLINO LIGANDS AND USES THEREOF 审中-公开
    目标MORPHOLINO配体及其用途

    公开(公告)号：US20150330978A1

    公开(公告)日：2015-11-19

    申请号：US14278866

    申请日：2014-05-15

    申请人： Vivonics, Inc.

    发明人： Vladimir Leo Gilman

    IPC分类号： G01N33/569 ,  C07F9/6558

    CPC分类号： C07F9/65583 ,  G01N33/569

    摘要： Morpholino ligands that have high specificity for targets, such as proteins, and that bind their targets through non Watson-Crick base pairing, are described. The use of such morpholino ligands for targeted delivery of loads, such as drugs or labels, are disclosed.

    摘要翻译： 描述了对靶标具有高特异性的Morpholino配体，例如蛋白质，并通过非沃森 - 克里克碱基配对结合其靶标。 公开了使用这样的吗啉配体来靶向递送载体，例如药物或标记物。

    Methods for identifying nucleic acid ligands
    7.
    发明授权
    Methods for identifying nucleic acid ligands 有权
    识别核酸配体的方法

    公开(公告)号：US09085773B2

    公开(公告)日：2015-07-21

    申请号：US13888919

    申请日：2013-05-07

    申请人： Vivonics, Inc.

    发明人： Vladimir Leo Gilman

    IPC分类号： G01N33/566 ,  C12Q1/68 ,  C12N15/115

    CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2320/11 ,  C12N2320/13

    摘要： The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate mixture of nucleic acids, in which the nucleic acids have different affinities for the target molecule, and separating in a single step nucleic acids that bind the target molecule with greatest affinity from nucleic acids that bind the target molecule with a lesser affinity and nucleic acids that do not bind the target molecule, thereby identifying the nucleic acid ligand of the target molecule.

    摘要翻译： 本发明一般涉及用于鉴定靶分子的核酸配体的方法。 在某些实施方案中，本发明提供了从核酸的候选混合物中鉴定靶分子的核酸配体的方法，包括使至少一种靶分子与核酸的候选混合物接触，其中核酸具有不同的亲和力 目标分子，并且在单个步骤中分离以最小亲和力的核酸和不结合靶分子的核酸以最大亲和力的核酸结合靶分子的核酸，从而鉴定靶分子的核酸配体 目标分子。

    NUCLEIC ACID LIGANDS AGAINST INFECTIOUS PRIONS
    9.
    发明申请
    NUCLEIC ACID LIGANDS AGAINST INFECTIOUS PRIONS 审中-公开
    针对感染性疾病的核酸配偶

    公开(公告)号：US20140377744A1

    公开(公告)日：2014-12-25

    申请号：US14460699

    申请日：2014-08-15

    申请人： Vivonics, Inc.

    发明人： Vladimir Leo Gilman

    IPC分类号： G01N33/566

    CPC分类号： G01N33/566 ,  A61K38/00 ,  C07K14/47 ,  C12N15/115 ,  C12N2310/16 ,  C12Q1/6816 ,  C12Q1/6883 ,  G01N2800/28 ,  C12Q2525/205

    摘要： The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.

    摘要翻译： 本发明一般涉及特异性结合感染性朊病毒的核酸配体，以及诊断受试者中传染性海绵状脑病的方法。 在某些实施方案中，本发明提供了结合感染性朊病毒的分离的核酸配体。 在其它实施方案中，本发明提供了用于诊断受试者中的传染性海绵状脑病的方法，包括从受试者获得组织或体液样品，使组织或体液与结合感染性朊病毒的核酸配体接触，从而 检测样品中的感染性朊病毒，并根据接触步骤的结果诊断传染性海绵状脑病。