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公开(公告)号:US20100184799A1
公开(公告)日:2010-07-22
申请号:US12685988
申请日:2010-01-12
申请人: WU DU , WILLIAM K. HAGMANN , SHUWEN HE , ZHONG LAI , SHRENIK K. SHAH , QUANG T. TRUONG
发明人: WU DU , WILLIAM K. HAGMANN , SHUWEN HE , ZHONG LAI , SHRENIK K. SHAH , QUANG T. TRUONG
IPC分类号: A61K31/437 , C07D471/04 , A61P3/10 , A61P9/12 , A61P9/10
CPC分类号: C07D471/04
摘要: Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
摘要翻译: 结构式I的β-咔啉衍生物是生长抑素亚型受体3(SSTR3)的选择性拮抗剂,可用于治疗2型糖尿病和通常与该疾病相关的病症,包括高血糖症,胰岛素抵抗,肥胖症, 脂质障碍和高血压。 这些化合物也可用于治疗抑郁症和焦虑症。