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    Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    3.
    发明申请
    Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
    苯丙氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20060111336A1

    公开(公告)日：2006-05-25

    申请号：US10537476

    申请日：2003-11-26

    申请人： Joseph Duffy ,  Robert Mathvink ,  Ann Weber ,  Jinyou Xu

    发明人： Joseph Duffy ,  Robert Mathvink ,  Ann Weber ,  Jinyou Xu

    IPC分类号： A61K31/426 ,  A61K31/401 ,  A61K31/397 ,  C07D277/56

    CPC分类号： C07D295/185 ,  A61K31/40 ,  C07D207/10 ,  C07D207/16 ,  C07D277/04

    摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Fused Triazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
    5.
    发明申请
    Fused Triazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 失效
    稠合三唑衍生物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20070208010A1

    公开(公告)日：2007-09-06

    申请号：US11660130

    申请日：2005-08-19

    申请人： Ann Weber ,  Wallace Ashton

    发明人： Ann Weber ,  Wallace Ashton

    IPC分类号： A61K31/551 ,  A61K31/519 ,  A61K31/498 ,  C07D487/14

    CPC分类号： C07D471/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D498/04 ,  C07D513/04

    摘要： The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新的稠合三唑衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
    6.
    发明申请
    Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes 有权
    哌啶基嘧啶二肽基肽酶抑制剂治疗糖尿病

    公开(公告)号：US20060040963A1

    公开(公告)日：2006-02-23

    申请号：US10520839

    申请日：2003-07-11

    申请人： Robert Mathvink ,  Scott Edmondson ,  Ann Weber

    发明人： Robert Mathvink ,  Scott Edmondson ,  Ann Weber

    IPC分类号： A61K31/519 ,  C07D487/02

    CPC分类号： C07D471/04

    摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
    7.
    发明申请
    Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes 有权
    六氢二氮杂酮作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US20060211682A1

    公开(公告)日：2006-09-21

    申请号：US10566235

    申请日：2004-07-27

    申请人： Gui-Bai Liang ,  Tesfaye Biftu ,  Danqing Feng ,  Ann Weber

    发明人： Gui-Bai Liang ,  Tesfaye Biftu ,  Danqing Feng ,  Ann Weber

    IPC分类号： A61K31/551 ,  C07D403/02 ,  C07D243/02

    CPC分类号： C07D243/14 ,  C07D401/06 ,  C07D487/04

    摘要： The present invention is directed to hexahydrodiazepinone compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的六氢二氮杂酮化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。