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公开(公告)号:US20070179196A1
公开(公告)日:2007-08-02
申请号:US10587682
申请日:2005-03-09
申请人: Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
发明人: Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin
IPC分类号: A01N37/08
CPC分类号: C07D471/04
摘要: Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R,1?, R,2?, R,3?, R,4? and R,5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译: 式I的羟基(四或六) - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂:(I)其中a,R ,1?,R 2?R ,3?,R ,4? 并且R ,5? 在本文中定义。 这些化合物可用于预防和治疗艾滋病毒感染以及预防,延迟艾滋病的发病和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分,任选与其它抗病毒剂,免疫调节剂,抗生素或疫苗组合使用。
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公开(公告)号:US20050176718A1
公开(公告)日:2005-08-11
申请号:US11056412
申请日:2005-02-11
申请人: Neville Anthony , Robert Gomez , Steven Young , Melissa Egbertson , John Wai , Linghang Zhuang , Mark Embrey , Lekhanh Tran , Jeffrey Melamed , H. Langford , James Guare , Thorsten Fisher , Samson Jolly , Michelle Kuo , Debra Perlow , Jennifer Bennett , Timothy Funk
发明人: Neville Anthony , Robert Gomez , Steven Young , Melissa Egbertson , John Wai , Linghang Zhuang , Mark Embrey , Lekhanh Tran , Jeffrey Melamed , H. Langford , James Guare , Thorsten Fisher , Samson Jolly , Michelle Kuo , Debra Perlow , Jennifer Bennett , Timothy Funk
IPC分类号: A61K31/4375 , A61K31/47 , A61K31/4985 , A61K31/541 , A61K31/554 , A61P31/12 , A61P31/18 , C07D20060101 , C07D215/48 , C07D221/00 , C07D241/00 , C07D471/00 , C07D471/04 , C07D471/16 , C07D487/00 , C07D519/00 , A61K31/498 , A61K31/4745 , C07D471/02 , C07D487/02
CPC分类号: C07D471/04
摘要: Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
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